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Sarna SK. Colonic Motility: From Bench Side to Bedside. San Rafael (CA): Morgan & Claypool Life Sciences; 2010.

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Colonic Motility: From Bench Side to Bedside.

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Cowles VE, Sarna SK. Relation between small intestinal motor activity and transit in secretory diarrhea. Am J Physiol 1990;259:G420–9. [PubMed: 2399985]
Johnson CP, Sarna SK, Baytiyeh R, Zhu YR, Cowles VE, Telford GL, Roza AM, Adams MB. Postprandial motor activity and its relationship to transit in the canine ileum. Surgery 1997;121:182–9.10.1016/S0039-6060(97)90288-9. [PubMed: 9037230] [CrossRef]
Sethi AK, Sarna SK. Contractile mechanisms of canine colonic propulsion. Am J Physiol 1995;268:G530–8. [PubMed: 7900814]
Sarna SK. Colonic motor activity. Surg Clin North Am 1993;73:1201–23. [PubMed: 8248835]
Haba T, Sarna SK. Regulation of gastroduodenal emptying of solids by gastropyloroduodenal contractions. Am J Physiol 1993;264:G261–71. [PubMed: 8447408]
Sarna SK. Giant migrating contractions and their myoelectric correlates in the small intestine. Am J Physiol 1987;253:G697–705. [PubMed: 3688231]
Lang IM, Sarna SK, Condon RE. Gastrointestinal motor correlates of vomiting in the dog: quantification and characterization as an independent phenomenon. Gastroenterology 1986;90:40–7. [PubMed: 3940253]
Karaus M, Sarna SK. Giant migrating contractions during defecation in the dog colon. Gastroenterology 1987;92:925–33. [PubMed: 3556998]
Otterson MF, Sarna SK. Neural control of small intestinal giant migrating contractions. Am J Physiol 1994;266:G576–84. [PubMed: 8178996]
Bassotti G, Iantorno G, Fiorella S, Bustos-Fernandez L, Bilder CR. Colonic motility in man: features in normal subjects and in patients with chronic idiopathic constipation. Am J Gastroenterol 1999;94:1760–70.10.1016/S0002-9270(99)00259-2. [PubMed: 10406232] [CrossRef]
Shi G, Ergun GA, Manka M, Kahrilas PJ. Lower esophageal sphincter relaxation characteristics using a sleeve sensor in clinical manometry. Am J Gastroenterol 1998;93:2373–9.10.1016/S0002-9270(98)00571-1. [PubMed: 9860395] [CrossRef]
Li M, Johnson CP, Adams MB, Sarna SK. Cholinergic and nitrergic regulation of in vivo giant migrating contractions in rat colon. Am J Physiol Gastrointest Liver Physiol 2002;283:G544–52. [PubMed: 12181166]
Fida R, Lyster DJ, Bywater RA, Taylor GS. Colonic migrating motor complexes (CMMCs) in the isolated mouse colon. Neurogastroenterol Motil 1997;9:99–107.10.1046/j.1365-2982.1997.d01-25.x. [PubMed: 9198085] [CrossRef]
Bush TG, Spencer NJ, Watters N, Sanders KM, Smith TK. Spontaneous migrating motor complexes occur in both the terminal ileum and colon of the C57BL/6 mouse in vitro. Auton Neurosci 2000;84:162–8.10.1016/S1566-0702(00)00201-0. [PubMed: 11111848] [CrossRef]
Gourcerol G, Wang L, Adelson DW, Larauche M, Tache Y, Million M. Cholinergic giant migrating contractions in conscious mouse colon assessed by using a novel noninvasive solid-state manometry method: modulation by stressors. Am J Physiol Gastrointest Liver Physiol 2009;296:G992–1002.10.1152/ajpgi.90436.2008. [PMC free article: PMC2696213] [PubMed: 19299579] [CrossRef]
Gonzalez A, Sarna SK. Neural regulation of in vitro giant contractions in the rat colon. Am J Physiol Gastrointest Liver Physiol 2001;281:G275–82. [PubMed: 11408281]
Gonzalez A, Sarna SK. Different types of contractions in rat colon and their modulation by oxidative stress. Am J Physiol Gastrointest Liver Physiol 2001;280:G546–54. [PubMed: 11254480]
Hipper K, Ehrlein HJ. Motility of the large intestine and flow of digesta in pigs. Res Vet Sci 2001;71:93–100.10.1053/rvsc.2001.0486. [PubMed: 11883896] [CrossRef]
Coulie B, Camilleri M, Bharucha AE, Sandborn WJ, Burton D. Colonic motility in chronic ulcerative proctosigmoiditis and the effects of nicotine on colonic motility in patients and healthy subjects. Aliment Pharmacol Ther 2001;15:653–63.10.1046/j.1365-2036.2001.00959.x. [PubMed: 11328259] [CrossRef]
Ford MJ, Camilleri M, Wiste JA, Hanson RB. Differences in colonic tone and phasic response to a meal in the transverse and sigmoid human colon. Gut 1995;37:264–9.10.1136/gut.37.2.264. [PMC free article: PMC1382729] [PubMed: 7557579] [CrossRef]
Coffin B, Lemann M, Flourie B, Picon L, Rambaud JC, Jian R. Ileal tone in humans: effects of locoregional distensions and eating. Am J Physiol 1994;267:G569–74. [PubMed: 7943322]
Chey WY, Jin HO, Lee MH, Sun SW, Lee KY. Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea. Am J Gastroenterol 2001;96:1499–506.10.1016/S0002-9270(01)02367-X. [PubMed: 11374689] [CrossRef]
Sarna SK. Enteric descending and afferent neural signaling stimulated by giant migrating contractions: essential contributing factors to visceral pain. Am J Physiol Gastrointest Liver Physiol 2007;292:G572–81. [PubMed: 16990445]
Bayliss W, Starling E. The movements and innervation of small intestine. J Physiol 1899; 24:99–143. [PMC free article: PMC1516636] [PubMed: 16992487]
Sarna SK, Soergel KH, Harig JM, Loo FD, Wood CM, Donahue KM, Ryan RP, Arndorfer RC. Spatial and temporal patterns of human jejunal contractions. Am J Physiol 1989;257:G423–32.10.1152/ajpgi.00332.2006. [PubMed: 2782412] [CrossRef]
Johnson CP, Sarna SK, Cowles VE, Baytiyeh R, Zhu YR, Buchmann E, Bonham L, Roza AM, Adams MB. Effects of transection and reanastomosis on postprandial jejunal transit and contractile activity. Surgery 1995;117:531–7. [PubMed: 7740424]
Quigley EM, Phillips SF, Dent J. Distinctive patterns of interdigestive motility at the canine ileocolonic junction. Gastroenterology 1984;87:836–44. [PubMed: 6468872]
Rao SS, Sadeghi P, Beaty J, Kavlock R, Ackerson K. Ambulatory 24-h colonic manometry in healthy humans. Am J Physiol Gastrointest Liver Physiol 2001;280:G629–39. [PubMed: 11254489]
Sarna SK. Myoelectric correlates of colonic motor complexes and contractile activity. Am J Physiol 1986;250:G213–20. [PubMed: 3953800]
Sarna S, Latimer P, Campbell D, Waterfall WE. Electrical and contractile activities of the human rectosigmoid. Gut 1982;23:698–705.10.1136/gut.23.8.698. [PMC free article: PMC1419134] [PubMed: 7095566] [CrossRef]
Bueno L, Fioramonti J, Ruckebusch Y, Frexinos J, Coulom P. Evaluation of colonic myoelectrical activity in health and functional disorders. Gut 1980;21:480–5.10.1136/gut.21.6.480. [PMC free article: PMC1419668] [PubMed: 7429310] [CrossRef]
Powell AK, Fida R, Bywater RA. Motility in the isolated mouse colon: migrating motor complexes, myoelectric complexes and pressure waves. Neurogastroenterol Motil 2003;15: 257–66.10.1046/j.1365-2982.2003.00412.x. [PubMed: 12787335] [CrossRef]
Bassotti G, Crowell MD, Cheskin LJ, Chami TN, Schuster MM, Whitehead WE. Physiological correlates of colonic motility in patients with irritable bowel syndrome. Z Gastroenterol 1998;36:811–7. [PubMed: 9795410]
Narducci F, Bassotti G, Gaburri M, Morelli A. Twenty four hour manometric recording of colonic motor activity in healthy man. Gut 1987;28:17–25.10.1136/gut.28.1.17. [PMC free article: PMC1432711] [PubMed: 3817580] [CrossRef]
Matsushima Y. [Studies on colonic motor correlates of spontaneous defecation in conscious dogs]. Nippon Heikatsukin Gakkai Zasshi 1989;25:137–46. [PubMed: 2622106]
Bampton PA, Dinning PG, Kennedy ML, Lubowski DZ, deCarle D, Cook IJ. Spatial and temporal organization of pressure patterns throughout the unprepared colon during spontaneous defecation. Am J Gastroenterol 2000;95:1027–35.10.1016/S0002-9270(99)00898-9. [PubMed: 10763955] [CrossRef]
Lemann M, Flourie B, Picon L, Coffin B, Jian R, Rambaud JC. Motor activity recorded in the unprepared colon of healthy humans. Gut 1995;37:649–53.10.1136/gut.37.5.649. [PMC free article: PMC1382869] [PubMed: 8549940] [CrossRef]
Cook IJ, Furukawa Y, Panagopoulos V, Collins PJ, Dent J. Relationships between spatial patterns of colonic pressure and individual movements of content. Am J Physiol Gastrointest Liver Physiol 2000;278:G329–41. [PubMed: 10666058]
Bassotti G, de Roberto G, Chistolini F, Sietchiping-Nzepa F, Morelli O, Morelli A. Twenty-four-hour manometric study of colonic propulsive activity in patients with diarrhea due to inflammatory (ulcerative colitis) and non-inflammatory (irritable bowel syndrome) conditions. Int J Colorectal Dis 2004;19:493–7.10.1007/s00384-004-0604-6. [PubMed: 15083326] [CrossRef]
Clemens CH, Samsom M, Van Berge Henegouwen GP, Smout AJ. Abnormalities of left colonic motility in ambulant nonconstipated patients with irritable bowel syndrome. Dig Dis Sci 2003;48:74–82. [PubMed: 12645793]
Furness J. The Enteric Nervous System. Blackwell, 2006.
Narducci F, Bassotti G, Daniotti S, Del Soldato P, Pelli MA, Morelli A. Identification of muscarinic receptor subtype mediating colonic response to eating. Dig Dis Sci 1985;30: 124–8.10.1007/BF01308197. [PubMed: 3838152] [CrossRef]
Narducci F, Bassotti G, Granata MT, Pelli MA, Gaburri M, Palumbo R, Morelli A. Colonic motility and gastric emptying in patients with irritable bowel syndrome. Effect of pretreatment with octylonium bromide. Dig Dis Sci 1986;31:241–6.10.1007/BF01318114. [PubMed: 3948628] [CrossRef]
Sullivan MA, Cohen S, Snape WJ, Jr. Colonic myoelectrical activity in irritable-bowel syndrome. Effect of eating and anticholinergics. N Engl J Med 1978;298:878–83. [PubMed: 345122]
Sarna SK, Gonzalez A, Ryan RP. Enteric locus of action of prokinetics: ABT-229, motilin, and erythromycin. Am J Physiol Gastrointest Liver Physiol 2000;278:G744–52. [PubMed: 10801267]
Costa M, Cuello AC, Furness JB, Franco R. Distribution of enteric neurons showing immunoreactivity for substance P in the guinea-pig ileum. Neuroscience 1980;5:323–31.10.1016/0306-4522(80)90108-6. [PubMed: 6154904] [CrossRef]
Grider JR. Identification of neurotransmitters regulating intestinal peristaltic reflex in humans. Gastroenterology 1989;97:1414–9. [PubMed: 2479588]
Grider JR. Tachykinins as transmitters of ascending contractile component of the peristaltic reflex. Am J Physiol 1989;257:G709–14. [PubMed: 2480718]
Furness JB. Types of neurons in the enteric nervous system. J Auton Nerv Syst 2000;81: 87–96.10.1016/S0165-1838(00)00127-2. [PubMed: 10869706] [CrossRef]
Grider JR. Interplay of VIP and nitric oxide in regulation of the descending relaxation phase of peristalsis. Am J Physiol 1993;264:G334–40. [PubMed: 8447417]
Grider JR, Jin JG. Distinct populations of sensory neurons mediate the peristaltic reflex elicited by muscle stretch and mucosal stimulation. J Neurosci 1994;14:2854–60. [PMC free article: PMC6577483] [PubMed: 7514213]
Murthy KS. Signaling for contraction and relaxation in smooth muscle of the gut. Annu Rev Physiol 2006;68:345–74.10.1146/annurev.physiol.68.040504.094707. [PubMed: 16460276] [CrossRef]
Somlyo AP, Somlyo AV. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003;83:1325–58. [PubMed: 14506307]
Brozovich FV. Myosin light chain phosphatase: it gets around. Circ Res 2002;90:500–2.10.1161/01.RES.0000014224.43774.03. [PubMed: 11909811] [CrossRef]
Hartshorne DJ, Ito M, Erdodi F. Myosin light chain phosphatase: subunit composition, interactions and regulation. J Muscle Res Cell Motil 1998;19:325–41. [PubMed: 9635276]
Somlyo AP, Somlyo AV. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 2000;522(Pt 2):177–85.10.1111/j.1469-7793.2000.t01-2-00177.x. [PMC free article: PMC2269761] [PubMed: 10639096] [CrossRef]
Lu G, Qian X, Berezin I, Telford GL, Huizinga JD, Sarna SK. Inflammation modulates in vitro colonic myoelectric and contractile activity and interstitial cells of Cajal. Am J Physiol 1997;273:G1233–45. [PubMed: 9435548]
Rich A, Kenyon JL, Hume JR, Overturf K, Horowitz B, Sanders KM. Dihydropyridine-sensitive calcium channels expressed in canine colonic smooth muscle cells. Am J Physiol 1993;264:C745–54. [PubMed: 7681626]
Huizinga JD, Stern HS, Chow E, Diamant NE, el-Sharkawy TY. Electrical basis of excitation and inhibition of human colonic smooth muscle. Gastroenterology 1986;90:1197–204. [PubMed: 3956938]
Serio R, Barajas-Lopez C, Daniel EE, Berezin I, Huizinga JD. Slow-wave activity in colon: role of network of submucosal interstitial cells of Cajal. Am J Physiol 1991;260: G636–45. [PubMed: 1708208]
Sato K, Sanders KM, Gerthoffer WT, Publicover NG. Sources of calcium utilized in cholinergic responses in canine colonic smooth muscle. Am J Physiol 1994;267:C1666–73. [PubMed: 7810609]
Liu X, Rusch NJ, Striessnig J, Sarna SK. Down-regulation of L-type calcium channels in inflamed circular smooth muscle cells of the canine colon. Gastroenterology 2001;120: 480–9.10.1053/gast.2001.21167. [PubMed: 11159888] [CrossRef]
Liu XR, Rusch NJ, Striessnig J, Sarna SK. Down-regulation of L-type calcium channels in inflamed circular smooth muscle cells of the canine colon. Gastroenterology 2001;120: 480–489.10.1053/gast.2001.21167. [PubMed: 11159888] [CrossRef]
Huizinga JD, Waterfall WE. Electrical correlate of circumferential contractions in human colonic circular muscle. Gut 1988;29:10–6.10.1136/gut.29.1.10. [PMC free article: PMC1433272] [PubMed: 3343001] [CrossRef]
Sanders KM. Excitation-contraction coupling without Ca2+ action potentials in small intestine. Am J Physiol 1983;244:C356–61. [PubMed: 6846525]
Large WA. Receptor-operated Ca2(+)-permeable nonselective cation channels in vascular smooth muscle: a physiologic perspective. J Cardiovasc Electrophysiol 2002;13:493–501. [PubMed: 12030534]
Ji G, Barsotti RJ, Feldman ME, Kotlikoff MI. Stretch-induced calcium release in smooth muscle. J Gen Physiol 2002;119:533–44.10.1085/jgp.20028514. [PMC free article: PMC2233869] [PubMed: 12034761] [CrossRef]
Kirber MT, Walsh JV, Jr., Singer JJ. Stretch-activated ion channels in smooth muscle: a mechanism for the initiation of stretch-induced contraction. Pflugers Arch 1988;412:339–45.10.1007/BF01907549. [PubMed: 2459658] [CrossRef]
Felder CC. Muscarinic acetylcholine receptors: signal transduction through multiple effectors. Faseb J 1995;9:619–25. [PubMed: 7768353]
Eglen RM, Reddy H, Watson N, Challiss RA. Muscarinic acetylcholine receptor subtypes in smooth muscle. Trends Pharmacol Sci 1994;15:114–9.10.1016/0165-6147(94)90047-7. [PubMed: 8016895] [CrossRef]
Wess J, Liu J, Blin N, Yun J, Lerche C, Kostenis E. Structural basis of receptor/G protein coupling selectivity studied with muscarinic receptors as model systems. Life Sci 1997; 60:1007–14.10.1016/S0024-3205(97)00041-6. [PubMed: 9121341] [CrossRef]
McFadzean I, Gibson A. The developing relationship between receptor-operated and store-operated calcium channels in smooth muscle. Br J Pharmacol 2002;135:1–13.10.1038/sj.bjp.0704468. [PMC free article: PMC1573126] [PubMed: 11786473] [CrossRef]
Sarna SK, Bardakjian BL, Waterfall WE, Lind JF. Human colonic electrical control activity (ECA). Gastroenterology 1980;78:1526–36. [PubMed: 7372071]
Snape WJ, Jr., Carlson GM, Cohen S. Colonic myoelectric activity in the irritable bowel syndrome. Gastroenterology 1976;70:326–30. [PubMed: 765183]
Taylor I, Duthie HL, Smallwood R, Linkens D. Large bowel myoelectrical activity in man. Gut 1975;16:808–14.10.1136/gut.16.10.808. [PMC free article: PMC1413095] [PubMed: 1205275] [CrossRef]
Provenzale L, Pisano M. Methods for recording electrical activity of the human colon in vivo. Clinical applications. Am J Dig Dis 1971;16:712–22. [PubMed: 5096787]
Couturier D, Roze C, Couturier-Turpin MH, Debray C. Electromyography of the colon in situ. An experimental study in man and in the rabbit. Gastroenterology 1969;56:317–22. [PubMed: 5764598]
Sanders KM, Koh SD, Ward SM. Interstitial cells of Cajal as pacemakers in the gastrointestinal tract. Annu Rev Physiol 2006;68:307–43.10.1146/annurev.physiol.68.040504.094718. [PubMed: 16460275] [CrossRef]
Sarna SK. Are interstitial cells of Cajal plurifunction cells in the gut? Am J Physiol Gastrointest Liver Physiol 2008;294:G372–90. [PubMed: 17932226]
Murthy KS. cAMP inhibits IP(3)-dependent Ca(2+) release by preferential activation of cGMP-primed PKG. Am J Physiol Gastrointest Liver Physiol 2001;281:G1238–45. [PubMed: 11668033]
Huber A, Trudrung P, Storr M, Franck H, Schusdziarra V, Ruth P, Allescher HD. Protein kinase G expression in the small intestine and functional importance for smooth muscle relaxation. Am J Physiol 1998;275:G629–37. [PubMed: 9756490]
Jiang H, Colbran JL, Francis SH, Corbin JD. Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries. J Biol Chem 1992;267: 1015–9. [PubMed: 1309758]
Jin JG, Murthy KS, Grider JR, Makhlouf GM. Activation of distinct cAMP- and cGMP-dependent pathways by relaxant agents in isolated gastric muscle cells. Am J Physiol 1993;264:G470–7. [PubMed: 8384796]
Murthy KS, Zhou H, Grider JR, Makhlouf GM. Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA. Am J Physiol Gastrointest Liver Physiol 2003;284:G1006–16. [PubMed: 12736149]
Daniel EaS, SK. The generation and conduction of activitry in smooth muscle, 1978.
Nelsen TS, Becker JC. Simulation of the electrical and mechanical gradient of the small intestine. Am J Physiol 1968;214:749–57. [PubMed: 5642936]
Sarna SK, Daniel EE, Kingma YJ. Simulation of slow-wave electrical activity of small intestine. Am J Physiol 1971;221:166–75. [PubMed: 5555782]
Sarna SK, Daniel EE, Kingma YJ. Simulation of the electric-control activity of the stomach by an array of relaxation oscillators. Am J Dig Dis 1972;17:299–310.10.1007/BF02231729. [PubMed: 5019836] [CrossRef]
Diamant NE, Bortoff A. Nature of the intestinal low-wave frequency gradient. Am J Physiol 1969;216:301–7. [PubMed: 4975008]
Smith TK, Reed JB, Sanders KM. Origin and propagation of electrical slow waves in circular muscle of canine proximal colon. Am J Physiol 1987;252:C215–24. [PubMed: 3826336]
Smith TK, Reed JB, Sanders KM. Effects of membrane potential on electrical slow waves of canine proximal colon. Am J Physiol 1988;255:C828–34. [PubMed: 3202152]
Bauer AJ, Sanders KM. Gradient in excitation-contraction coupling in canine gastric antral circular muscle. J Physiol 1985;369:283–94. [PMC free article: PMC1192649] [PubMed: 4093884]
Horiguchi K, Semple GS, Sanders KM, Ward SM. Distribution of pacemaker function through the tunica muscularis of the canine gastric antrum. J Physiol 2001;537:237–50.10.1111/j.1469-7793.2001.0237k.x. [PMC free article: PMC2278930] [PubMed: 11711577] [CrossRef]
Malysz J, Thuneberg L, Mikkelsen HB, Huizinga JD. Action potential generation in the small intestine of W mutant mice that lack interstitial cells of Cajal. Am J Physiol 1996;271:G387–99. [PubMed: 8843760]
Szurszewski JH, Farrugia G. Carbon monoxide is an endogenous hyperpolarizing factor in the gastrointestinal tract. Neurogastroenterol Motil 2004;16 Suppl 1:81–5.10.1111/j.1743-3150.2004.00480.x. [PubMed: 15066010] [CrossRef]
Hagger R, Gharaie S, Finlayson C, Kumar D. Regional and transmural density of interstitial cells of Cajal in human colon and rectum. Am J Physiol 1998;275:G1309–16. [PubMed: 9843767]
Rumessen JJ, Peters S, Thuneberg L. Light- and electron microscopical studies of interstitial cells of Cajal and muscle cells at the submucosal border of human colon. Lab Invest 1993;68:481–95. [PubMed: 8479156]
Faussone-Pellegrini MS, Pantalone D, Cortesini C. Smooth muscle cells, interstitial cells of Cajal and myenteric plexus interrelationships in the human colon. Acta Anat (Basel) 1990; 139:31–44.10.1159/000146975. [PubMed: 2288187] [CrossRef]
He CL, Burgart L, Wang L, Pemberton J, Young-Fadok T, Szurszewski J, Farrugia G. Decreased interstitial cell of cajal volume in patients with slow-transit constipation. Gastroenterology 2000;118:14–21.10.1016/S0016-5085(00)70409-4. [PubMed: 10611149] [CrossRef]
Alberti E, Mikkelsen HB, Wang X, Diaz M, Larsen JO, Huizinga JD, Jimenez M. Pacemaker activity and inhibitory neurotransmission in the colon of Ws/Ws mutant rats. Am J Physiol Gastrointest Liver Physiol 2007.10.1152/ajpgi.00136.2006. [PubMed: 17322067] [CrossRef]
Sanders KM, Publicover NG, Ward SM. Involvement of interstitial cells of Cajal in pacemaker activity of canine colon. J Smooth Muscle Res 1991;27:1–11. [PubMed: 1668567]
Farrugia G, Lei S, Lin X, Miller SM, Nath KA, Ferris CD, Levitt M, Szurszewski JH. A major role for carbon monoxide as an endogenous hyperpolarizing factor in the gastrointestinal tract. Proc Natl Acad Sci USA 2003;100:8567–70.10.1073/pnas.1431233100. [PMC free article: PMC166269] [PubMed: 12832617] [CrossRef]
Wood JD. Physiology of the enteric nervous system. Raven, 1994.
Lomax AE, Furness JB. Neurochemical classification of enteric neurons in the guinea-pig distal colon. Cell Tissue Res 2000;302:59–72.10.1007/s004410000260. [PubMed: 11079716] [CrossRef]
Costa M, Brookes SJ, Steele PA, Gibbins I, Burcher E, Kandiah CJ. Neurochemical classification of myenteric neurons in the guinea-pig ileum. Neuroscience 1996;75:949–67.10.1016/0306-4522(96)00275-8. [PubMed: 8951887] [CrossRef]
Timmermans JP, Adriaensen D, Cornelissen W, Scheuermann DW. Structural organization and neuropeptide distribution in the mammalian enteric nervous system, with special attention to those components involved in mucosal reflexes. Comp Biochem Physiol A Physiol 1997;118:331–40.10.1016/S0300-9629(96)00314-3. [PubMed: 9366065] [CrossRef]
Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007;132(1): p. 397–414.10.1053/j.gastro.2006.11.002. [PubMed: 17241888] [CrossRef]
Dogiel A. Uber den Bau der Ganglien in den Geflechten des Darmes und der Gallenblase des Menschen und der Saugetiere. Arch Anat Physiol Leipzig Anat Abt Jg 1899:130–158.
Cornelissen W, de Laet A, Kroese AB, van Bogaert PP, Scheuermann DW, Timmermans JP. Excitatory synaptic inputs on myenteric Dogiel type II neurones of the pig ileum. J Comp Neurol 2001;432:137–54.10.1002/cne.1093. [PubMed: 11241382] [CrossRef]
Palmer JM, Schemann M, Tamura K, Wood JD. Calcitonin gene-related peptide excites myenteric neurons. Eur J Pharmacol 1986;132:163–70.10.1016/0014-2999(86)90601-1. [PubMed: 3493162] [CrossRef]
Lomax AE, Sharkey KA, Bertrand PP, Low AM, Bornstein JC, Furness JB. Correlation of morphology, electrophysiology and chemistry of neurons in the myenteric plexus of the guinea-pig distal colon. J Auton Nerv Syst 1999;76:45–61.10.1016/S0165-1838(99)00008-9. [PubMed: 10323306] [CrossRef]
Nurgali K, Stebbing MJ, Furness JB. Correlation of electrophysiological and morphological characteristics of enteric neurons in the mouse colon. J Comp Neurol 2004;468:112–24.10.1002/cne.10948. [PubMed: 14648694] [CrossRef]
Takahashi A, Tomomasa T, Kaneko H, Hatori R, Ishige T, Suzuki M, Mochiki E, Morikawa A, Kuwano H. In vivo recording of colonic motility in conscious rats with deficiency of interstitial cells of Cajal, with special reference to the effects of nitric oxide on colonic motility. J Gastroenterol 2005;40:1043–8.10.1007/s00535-005-1688-7. [PubMed: 16322948] [CrossRef]
Orihata M, Sarna SK. Inhibition of nitric oxide synthase delays gastric emptying of solid meals. J Pharmacol Exp Ther 1994;271:660–70. [PubMed: 7525940]
Sarna SK et al.,Nitric oxide regulates migrating motor complex cycling and its postprandial disruption. Am J Physiol 1993;265(4 Pt 1):G749–66. [PubMed: 7694478]
Grider JR. Neurotransmitters mediating the intestinal peristaltic reflex in the mouse. J Pharmacol Exp Ther 2003;307:460–7.10.1124/jpet.103.053512. [PubMed: 12966154] [CrossRef]
Grider JR, Makhlouf GM. Colonic peristaltic reflex: identification of vasoactive intestinal peptide as mediator of descending relaxation. Am J Physiol 1986;251:G40–5. [PubMed: 3014895]
Sarna SK. Neuronal locus and cellular signaling for stimulation of ileal giant migrating and phasic contractions. Am J Physiol Gastrointest Liver Physiol 2003;284:G789–97. [PubMed: 12505883]
Porter AJ, Wattchow DA, Brookes SJ, Costa M. The neurochemical coding and projections of circular muscle motor neurons in the human colon. Gastroenterology 1997;113:1916–23.10.1016/S0016-5085(97)70011-8. [PubMed: 9394731] [CrossRef]
Beckett EA, Takeda Y, Yanase H, Sanders KM, Ward SM. Synaptic specializations exist between enteric motor nerves and interstitial cells of Cajal in the murine stomach. J Comp Neurol 2005;493:193–206.10.1002/cne.20746. [PubMed: 16255030] [CrossRef]
Horiguchi K, Sanders KM, Ward SM. Enteric motor neurons form synaptic-like junctions with interstitial cells of Cajal in the canine gastric antrum. Cell Tissue Res 2003;311: 299–313. [PubMed: 12658438]
Wang XY, Paterson C, Huizinga JD. Cholinergic and nitrergic innervation of ICC-DMP and ICC-IM in the human small intestine. Neurogastroenterol Motil 2003;15:531–43.10.1046/j.1365-2982.2003.00429.x. [PubMed: 14507353] [CrossRef]
Faussone-Pellegrini MS, Pantalone D, Cortesini C. An ultrastructural study of the smooth muscle cells and nerve endings of the human stomach. J Submicrosc Cytol Pathol 1989;21: 421–37. [PubMed: 2790730]
Burns AJ, Lomax AE, Torihashi S, Sanders KM, Ward SM. Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach. Proc Natl Acad Sci USA 1996;93: 12008–13.10.1073/pnas.93.21.12008. [PMC free article: PMC38174] [PubMed: 8876253] [CrossRef]
Ward SM, Beckett EA, Wang X, Baker F, Khoyi M, Sanders KM. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci 2000; 20:1393–403. [PMC free article: PMC6772355] [PubMed: 10662830]
Altdorfer K, Bagameri G, Donath T, Feher E. Nitric oxide synthase immunoreactivity of interstitial cells of Cajal in experimental colitis. Inflamm Res 2002;51:569–71.10.1007/PL00012430. [PubMed: 12558189] [CrossRef]
Ward SM, Sanders KM. Interstitial cells of Cajal: primary targets of enteric motor innervation. Anat Rec 2001;262:125–35.10.1002/1097-0185(20010101)262:1<125::AID-AR1017>3.3.CO;2-9. [PubMed: 11146435] [CrossRef]
Vannucchi MG, Corsani L, Bani D, Faussone-Pellegrini MS. Myenteric neurons and interstitial cells of Cajal of mouse colon express several nitric oxide synthase isoforms. Neurosci Lett 2002;326:191–5.10.1016/S0304-3940(02)00338-5. [PubMed: 12095654] [CrossRef]
Goyal RK, Chaudhury A. Mounting evidence against the role of ICC in neurotransmission to smooth muscle in the gut. Am J Physiol Gastrointest Liver Physiol 2009.10.1152/ajpgi.00426.2009. [PMC free article: PMC2806097] [PubMed: 19892937] [CrossRef]
Zhang Y, Carmichael SA, Wang XY, Huizinga JD, Paterson WG. Neurotransmission in lower esophageal Sphincter of W/Wv mutant mice. Am J Physiol Gastrointest Liver Physiol 2009.10.1152/ajpgi.00266.2009. [PubMed: 19850967] [CrossRef]
Herkenham M. Extrasynaptic receptors and parasynaptic communication in the brain. Brain Res Bull 1999;50:351–2.10.1016/S0361-9230(99)00101-X. [PubMed: 10643432] [CrossRef]
Nicholson C. Signals that go with the flow. Trends Neurosci 1999;22:143–5.10.1016/S0166-2236(98)01388-5. [PubMed: 10203848] [CrossRef]
Sykova E. Extrasynaptic volume transmission and diffusion parameters of the extracellular space. Neuroscience 2004;129:861–76.10.1016/j.neuroscience.2004.06.077. [PubMed: 15561404] [CrossRef]
Vizi ES, Kiss JP, Lendvai B. Nonsynaptic communication in the central nervous system. Neurochem Int 2004;45:443–51.10.1016/j.neuint.2003.11.016. [PubMed: 15186910] [CrossRef]
Porter AJ, Wattchow DA, Brookes SJ, Costa M. Cholinergic and nitrergic interneurones in the myenteric plexus of the human colon. Gut 2002;51:70–5.10.1136/gut.51.1.70. [PMC free article: PMC1773285] [PubMed: 12077095] [CrossRef]
Frantzides CT, Sarna SK, Matsumoto T, Lang IM, Condon RE. An intrinsic neural pathway for long intestino-intestinal inhibitory reflexes. Gastroenterology 1987;92: 594–603. [PubMed: 3028893]
Sarna S, Stoddard C, Belbeck L, McWade D. Intrinsic nervous control of migrating myoelectric complexes. Am J Physiol 1981;241:G16–23. [PubMed: 7246780]
Wattchow DA, Porter AJ, Brookes SJ, Costa M. The polarity of neurochemically defined myenteric neurons in the human colon. Gastroenterology 1997;113:497–506.10.1053/gast.1997.v113.pm9247469. [PubMed: 9247469] [CrossRef]
Nichols K, Staines W, Krantis A. Neural sites of the human colon colocalize nitric oxide synthase-related NADPH diaphorase activity and neuropeptide Y. Gastroenterology 1994; 107:968–75. [PubMed: 7523222]
Burleigh DE, Furness JB. Distribution and actions of galanin and vasoactive intestinal peptide in the human colon. Neuropeptides 1990;16:77–82.10.1016/0143-4179(90)90115-F. [PubMed: 1701228] [CrossRef]
Wardell CF, Bornstein JC, Furness JB. Projections of 5-hydroxytryptamine-immunoreactive neurons in guinea-pig distal colon. Cell Tissue Res 1994;278:379–87.10.1007/s004410050227. [PubMed: 8001089] [CrossRef]
Neunlist M, Dobreva G, Schemann M. Characteristics of mucosally projecting myenteric neurones in the guinea-pig proximal colon. J Physiol 1999;517( Pt 2):533–46.10.1111/j.1469-7793.1999.0533t.x. [PMC free article: PMC2269343] [PubMed: 10332100] [CrossRef]
Kunze WA, Furness JB. The enteric nervous system and regulation of intestinal motility. Annu Rev Physiol 1999;61:117–42.10.1146/annurev.physiol.61.1.117. [PubMed: 10099684] [CrossRef]
Pan H, Gershon MD. Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine. J Neurosci 2000;20:3295–309. [PMC free article: PMC6773125] [PubMed: 10777793]
Wood JD. Enteric nervous system: reflexes, pattern generators and motility. Curr Opin Gastroenterol 2008;24:149–58.10.1097/MOG.0b013e3282f56125. [PubMed: 18301264] [CrossRef]
Wade PR, Wood JD. Electrical behavior of myenteric neurons in guinea pig distal colon. Am J Physiol 1988;254:G522–30. [PubMed: 3354674]
Messenger JP, Bornstein JC, Furness JB. Electrophysiological and morphological classification of myenteric neurons in the proximal colon of the guinea-pig. Neuroscience 1994;60: 227–44.10.1016/0306-4522(94)90217-8. [PubMed: 8052415] [CrossRef]
Nurgali K, Furness JB, Stebbing MJ. Correlation of electrophysiology, shape and synaptic properties of myenteric AH neurons of the guinea pig distal colon. Auton Neurosci 2003; 103:50–64.10.1016/S1566-0702(02)00212-6. [PubMed: 12531398] [CrossRef]
Wade PR, Wood JD. Synaptic behavior of myenteric neurons in guinea pig distal colon. Am J Physiol 1988;255:G184–90. [PubMed: 2900605]
Brookes SJ, Ewart WR, Wingate DL. Intracellular recordings from myenteric neurones in the human colon. J Physiol 1987;390:305–18. [PMC free article: PMC1192182] [PubMed: 2895177]
Sarna SK. Effect of fluid perfusion and cleansing on canine colonic motor activity. Am J Physiol 1992;262:G62–8. [PubMed: 1733271]
Morse D, Sassone-Corsi P. Time after time: inputs to and outputs from the mammalian circadian oscillators. Trends Neurosci 2002;25:632–7.10.1016/S0166-2236(02)02274-9. [PubMed: 12446131] [CrossRef]
Stankiewicz M, Grolleau F, Kielbasiewicz E, Panek I, Lapied B, Pelhate M. [Spontaneous activity of neural membranes]. Postepy Hig Med Dosw 2002;56:255–62. [PubMed: 12194238]
Fricker D, Miles R. Interneurons, spike timing, and perception. Neuron 2001;32:771–4.10.1016/S0896-6273(01)00528-1. [PubMed: 11738024] [CrossRef]
Sarna SK. Cyclic motor activity; migrating motor complex: 1985. Gastroenterology 1985; 89:894–913. [PubMed: 3896912]
Frexinos J, Bueno L, Fioramonti J. Diurnal changes in myoelectric spiking activity of the human colon. Gastroenterology 1985;88:1104–10. [PubMed: 4038956]
Liu LW, Huizinga JD. Canine colonic circular muscle generates action potentials without the pacemaker component. Can J Physiol Pharmacol 1994;72:70–81. [PubMed: 7516818]
Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007;132:397–414.10.1053/j.gastro.2006.11.002. [PubMed: 17241888] [CrossRef]
Graf S, Sarna SK. 5-HT-induced jejunal motor activity: enteric locus of action and receptor subtypes. Am J Physiol 1996;270:G992–1000. [PubMed: 8764207]
Schang JC, Hemond M, Hebert M, Pilote M. Myoelectrical activity and intraluminal flow in human sigmoid colon. Dig Dis Sci 1986;31:1331–7.10.1007/BF01299811. [PubMed: 3803135] [CrossRef]
Schang JC, Dapoigny M, Devroede G. Stimulation of colonic peristalsis by vasopressin: electromyographic study in normal subjects and patients with chronic idiopathic constipation. Can J Physiol Pharmacol 1987;65:2137–41. [PubMed: 3427547]
Pluja L, Alberti E, Fernandez E, Mikkelsen HB, Thuneberg L, Jimenez M. Evidence supporting presence of two pacemakers in rat colon. Am J Physiol Gastrointest Liver Physiol 2001; 281:G255–66. [PubMed: 11408279]
Lee CW, Sarna SK, Singaram C, Casper MA. Ca2+ channel blockade by verapamil inhibits GMCs and diarrhea during small intestinal inflammation. Am J Physiol 1997;273:G785–94. [PubMed: 9357819]
Biancani P, Harnett KM, Sohn UD, Rhim BY, Behar J, Hillemeier C, Bitar KN. Differential signal transduction pathways in cat lower esophageal sphincter tone and response to ACh. Am J Physiol 1994;266:G767–74. [PubMed: 8203523]
Tsukamoto M, Sarna SK, Condon RE. A novel motility effect of tachykinins in normal and inflamed colon. Am J Physiol 1997;272:G1607–14. [PubMed: 9227499]
Hou JY, Otterson MF, Sarna SK. Local effect of substance P on colonic motor activity in different experimental states. Am J Physiol 1989;256:G997–1004. [PubMed: 2472074]
Sethi AK, Sarna SK. Colonic motor response to a meal in acute colitis. Gastroenterology 1991;101:1537–46. [PubMed: 1955120]
Sethi AK, Sarna SK. Colonic motor activity in acute colitis in conscious dogs. Gastroenterology 1991;100:954–63. [PubMed: 2001831]
Sarna SK. Differential signal transduction pathways to stimulate colonic giant migrating and phasic contractions. Gastroenterology 2000;118:A837.10.1016/S0016-5085(00)85491-8. [CrossRef]
Olofsson B. Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. Cell Signal 1999;11:545–54.10.1016/S0898-6568(98)00063-1. [PubMed: 10433515] [CrossRef]
Fujihara H, Walker LA, Gong MC, Lemichez E, Boquet P, Somlyo AV, Somlyo AP. Inhibition of RhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin DC3B. Mol Biol Cell 1997;8:2437–47. [PMC free article: PMC25718] [PubMed: 9398666]
Gong MC, Fujihara H, Somlyo AV, Somlyo AP. Translocation of rhoA associated with Ca2+ sensitization of smooth muscle. J Biol Chem 1997;272:10704–9. [PubMed: 9099720]
Murthy KS, Zhou H, Grider JR, Brautigan DL, Eto M, Makhlouf GM. Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. Biochem J 2003;374:145–55.10.1042/BJ20021274. [PMC free article: PMC1223565] [PubMed: 12733988] [CrossRef]
Murthy KS, Grider JR, Kuemmerle JF, Makhlouf GM. Sustained muscle contraction induced by agonists, growth factors, and Ca(2+) mediated by distinct PKC isozymes. Am J Physiol Gastrointest Liver Physiol 2000;279:G201–10. [PubMed: 10898764]
Shi XZ, Choudhury BK, Pasricha PJ, Sarna SK. A novel role of VIP in colonic motility function: induction of excitation-transcription coupling in smooth muscle cells. Gastroenterology 2007;132:1388–400.10.1053/j.gastro.2007.02.016. [PubMed: 17408637] [CrossRef]
Shi XZ, Sarna SK. Gene therapy of Cav1.2 channel with VIP and VIP receptor agonists and antagonists: a novel approach to designing promotility and antimotility agents. Am J Physiol Gastrointest Liver Physiol 2008;295:G187–G196.10.1152/ajpgi.00047.2008. [PMC free article: PMC2494720] [PubMed: 18467505] [CrossRef]
Lomax AE, Fernandez E, Sharkey KA. Plasticity of the enteric nervous system during intestinal inflammation. Neurogastroenterol Motil 2005;17:4–15.10.1111/j.1365-2982.2004.00607.x. [PubMed: 15670258] [CrossRef]
Shi XZ, Sarna SK. G protein-mediated dysfunction of excitation-contraction coupling in ileal inflammation. Am J Physiol Gastrointest Liver Physiol 2004;286:G899–905.10.1152/ajpgi.00408.2003. [PubMed: 15132948] [CrossRef]
Shi XZ, Sarna SK. Impairment of Ca(2+) mobilization in circular muscle cells of the inflamed colon. Am J Physiol Gastrointest Liver Physiol 2000;278:G234–42. [PubMed: 10666047]
Alvarez W. An Introduction to Gastroenterology. Paul B. Hoeber, 1948.
Alvarez WCSE. Conduction in the small intestine. Am J Physiol 1919;26:99–143.
White H, Rainey, WR, Monaghan, B and Harris, AS. Observations on the nervous control of the ileocecal sphincter and on intestinal movements in an unanesthetized human subject. Am J Physiol 1934;108:449–457.
Roden S. An experimental study on intestinal movements; particularly with regard to ileus conditions in cases of trauma and peritonitis. Acta Chirur Scandinavica 1937;80:1–146.
Kadowaki M, Wade PR, Gershon MD. Participation of 5-HT3, 5-HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon. Am J Physiol 1996;271:G849–57. [PubMed: 8944700]
Grider JR. Gastrin-releasing peptide is a modulatory neurotransmitter of the descending phase of the peristaltic reflex. Am J Physiol Gastrointest Liver Physiol 2004;287:G1109–15.10.1152/ajpgi.00080.2004. [PubMed: 15297260] [CrossRef]
Grider JR, Kuemmerle JF, Jin JG. 5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons. Am J Physiol 1996;270:G778–82. [PubMed: 8967488]
Costa M, Furness JB. The peristaltic reflex: an analysis of the nerve pathways and their pharmacology. Naunyn Schmiedebergs Arch Pharmacol 1976;294:47–60. [PubMed: 1004629]
Bian XC, Heffer LF, Gwynne RM, Bornstein JC, Bertrand PP. Synaptic transmission in simple motility reflex pathways excited by distension in guinea pig distal colon. Am J Physiol Gastrointest Liver Physiol 2004;287:G1017–27.10.1152/ajpgi.00039.2004. [PubMed: 15256359] [CrossRef]
Wade PR, Wood JD. Actions of serotonin and substance P on myenteric neurons of guinea-pig distal colon. Eur J Pharmacol 1988;148:1–8.10.1016/0014-2999(88)90447-5. [PubMed: 2454828] [CrossRef]
Gershon MD. Review article: serotonin receptors and transporters—roles in normal and abnormal gastrointestinal motility. Aliment Pharmacol Ther 2004;20 Suppl 7:3–14.10.1111/j.1365-2036.2004.02180.x. [PubMed: 15521849] [CrossRef]
[189] Latimer P, Sarna S, Campbell D, Latimer M, Waterfall W, Daniel EE. Colonic motor and myoelectrical activity: a comparative study of normal subjects, psychoneurotic patients, and patients with irritable bowel syndrome. Gastroenterology 1981;80:893–901. [PubMed: 7202974]
Kuriyama H, Osa T, Toida N. Nervous factors influencing the membrane activity of intestinal smooth muscle. J Physiol 1967;191:257–70. [PMC free article: PMC1365452] [PubMed: 6050104]
Kuriyama H, Osa T, Toida N. Electrophysiological study of the intestinal smooth muscle of the guinea-pig. J Physiol 1967;191:239–55. [PMC free article: PMC1365451] [PubMed: 6050103]
Donnelly G, Jackson TD, Ambrous K, Ye J, Safdar A, Farraway L, Huizinga JD. The myogenic component in distention-induced peristalsis in the guinea pig small intestine. Am J Physiol Gastrointest Liver Physiol 2001;280:G491–500. [PubMed: 11171633]
Jin JG, Foxx-Orenstein AE, Grider JR. Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors. J Pharmacol Exp Ther 1999; 288:93–7. [PubMed: 9862758]
Scott SM. Manometric techniques for the evaluation of colonic motor activity: current status. Neurogastroenterol Motil 2003;15:483–513.10.1046/j.1365-2982.2003.00434.x. [PubMed: 14507350] [CrossRef]
Bampton PA, Dinning PG, Kennedy ML, Lubowski DZ, Cook IJ. Prolonged multi-point recording of colonic manometry in the unprepared human colon: providing insight into potentially relevant pressure wave parameters. Am J Gastroenterol 2001;96:1838–48.10.1016/S0002-9270(01)02487-X,10.1111/j.1572-0241.2001.03924.x. [PubMed: 11419837] [CrossRef] [CrossRef]
Sloots CE, Felt-Bersma RJ. Effect of bowel cleansing on colonic transit in constipation due to slow transit or evacuation disorder. Neurogastroenterol Motil 2002;14:55–61.10.1046/j.1365-2982.2002.00304.x. [PubMed: 11874554] [CrossRef]
Bassotti G, Gaburri M. Manometric investigation of high-amplitude propagated contractile activity of the human colon. Am J Physiol 1988;255:G660–4. [PubMed: 3189553]
Hammer J, Phillips SF. Fluid loading of the human colon: effects on segmental transit and stool composition. Gastroenterology 1993;105:988–98. [PubMed: 8405884]
Proano M, Camilleri M, Phillips SF, Brown ML, Thomforde GM. Transit of solids through the human colon: regional quantification in the unprepared bowel. Am J Physiol 1990;258:G856–62. [PubMed: 2360632]
Furukawa Y, Cook IJ, Panagopoulos V, McEvoy RD, Sharp DJ, Simula M. Relationship between sleep patterns and human colonic motor patterns. Gastroenterology 1994;107: 1372–81. [PubMed: 7926501]
Herbst F, Kamm MA, Morris GP, Britton K, Woloszko J, Nicholls RJ. Gastrointestinal transit and prolonged ambulatory colonic motility in health and faecal incontinence. Gut 1997;41:381–9.10.1136/gut.41.3.381. [PMC free article: PMC1891481] [PubMed: 9378396] [CrossRef]
Soffer EE, Scalabrini P, Wingate DL. Prolonged ambulant monitoring of human colonic motility. Am J Physiol 1989;257:G601–6. [PubMed: 2801942]
Bassotti G, Gaburri M, Imbimbo BP, Rossi L, Farroni F, Pelli MA, Morelli A. Colonic mass movements in idiopathic chronic constipation. Gut 1988;29:1173–9.10.1136/gut.29.9.1173. [PMC free article: PMC1434376] [PubMed: 3197990] [CrossRef]
Kumar D, Wingate D, Ruckebusch Y. Circadian variation in the propagation velocity of the migrating motor complex. Gastroenterology 1986;91:926–30. [PubMed: 3743969]
Snyder F, Hobson JA, Morrison DF, Goldfrank F. Changes in respiration, heart rate, and systolic blood pressure in human sleep. J Appl Physiol 1964;19:417–22. [PubMed: 14174589]
Orem J. Medullary respiratory neuron activity: relationship to tonic and phasic REM sleep. J Appl Physiol 1980;48:54–65. [PubMed: 7353979]
Kline LR, Hendricks JC, Davies RO, Pack AI. Control of activity of the diaphragm in rapid-eye-movement sleep. J Appl Physiol 1986;61:1293–300. [PubMed: 3781945]
Niederau C, Faber S, Karaus M. Cholecystokinin’s role in regulation of colonic motility in health and in irritable bowel syndrome. Gastroenterology 1992;102:1889–98. [PubMed: 1587408]
Snape WJ, Jr., Matarazzo SA, Cohen S. Effect of eating and gastrointestinal hormones on human colonic myoelectrical and motor activity. Gastroenterology 1978;75:373–8. [PubMed: 680491]
Steadman CJ, Phillips SF, Camilleri M, Haddad AC, Hanson RB. Variation of muscle tone in the human colon. Gastroenterology 1991;101:373–81. [PubMed: 2065913]
Rao SS, Kavelock R, Beaty J, Ackerson K, Stumbo P. Effects of fat and carbohydrate meals on colonic motor response. Gut 2000;46:205–11.10.1136/gut.46.2.205. [PMC free article: PMC1727817] [PubMed: 10644314] [CrossRef]
Sarna SK, Lang IM. Colonic motor response to a meal in dogs. Am J Physiol 1989;257:G830–5. [PubMed: 2596613]
Bassotti G, Betti C, Imbimbo BP, Pelli MA, Morelli A. Colonic motor response to eating: a manometric investigation in proximal and distal portions of the viscus in man. Am J Gastroenterol 1989;84:118–22. [PubMed: 2916518]
Tansy MF, Kendall FM, Murphy JJ. The reflex nature of the gastrocolic propulsive response in the dog. Surg Gynecol Obstet 1972;135:404–10. [PubMed: 5054163]
Tansy MF, Kendall FM, Murphy JJ. A pharmacologic analysis of the gastroileal and gastrocolic reflexes in the dog. Surg Gynecol Obstet 1972;135:763–8. [PubMed: 5084249]
Collman PI, Grundy D, Scratcherd T, Wach RA. Vago-vagal reflexes to the colon of the anaesthetized ferret. J Physiol 1984;352:395–402. [PMC free article: PMC1193219] [PubMed: 6747895]
Snape WJ, Jr., Wright SH, Battle WM, Cohen S. The gastrocolic response: evidence for a neural mechanism. Gastroenterology 1979;77:1235–40. [PubMed: 583043]
Bassotti G, Calcara C, Annese V, Fiorella S, Roselli P, Morelli A. Nifedipine and verapamil inhibit the sigmoid colon myoelectric response to eating in healthy volunteers. Dis Colon Rectum 1998;41:377–80.10.1007/BF02237495. [PubMed: 9514436] [CrossRef]
Cremonini F, Camilleri M, McKinzie S, Carlson P, Camilleri CE, Burton D, Thomforde G, Urrutia R, Zinsmeister AR. Effect of CCK-1 antagonist, dexloxiglumide, in female patients with irritable bowel syndrome: a pharmacodynamic and pharmacogenomic study. Am J Gastroenterol 2005;100:652–63.10.1111/j.1572-0241.2005.41081.x. [PubMed: 15743365] [CrossRef]
Bassotti G, Imbimbo BP, Betti C, Erbella GS, Pelli MA, Morelli A. Edrophonium chloride for testing colonic contractile activity in man. Acta Physiol Scand 1991;141:289–93.10.1111/j.1748-1716.1991.tb09083.x. [PubMed: 1858502] [CrossRef]
Harris ML, Hobson AR, Hamdy S, Thompson DG, Akkermans LM, Aziz Q. Neurophysiological evaluation of healthy human anorectal sensation. Am J Physiol Gastrointest Liver Physiol 2006;291:G950–8.10.1152/ajpgi.00010.2006. [PubMed: 16690905] [CrossRef]
Thomson A. Anorectal physiology. Surg Clin North Am 2002;82:1115–1123. [PubMed: 12516842]
Rattan S. The internal anal sphincter: regulation of smooth muscle tone and relaxation. Neurogastroenterol Motil 2005;17 Suppl 1:50–9.10.1111/j.1365-2982.2005.00659.x. [PubMed: 15836455] [CrossRef]
Dinning PG, Fuentealba SE, Kennedy ML, Lubowski DZ, Cook IJ. Sacral nerve stimulation induces pan-colonic propagating pressure waves and increases defecation frequency in patients with slow-transit constipation. Colorectal Dis 2007;9:123–32.10.1111/j.1463-1318.2006.01096.x. [PubMed: 17223936] [CrossRef]
Kamm MA, van der Sijp JR, Lennard-Jones JE. Observations on the characteristics of stimulated defaecation in severe idiopathic constipation. Int J Colorectal Dis 1992;7:197–201.10.1007/BF00341220. [PubMed: 1293240] [CrossRef]
De Schryver AM, Samsom M, Smout AI. Effects of a meal and bisacodyl on colonic motility in healthy volunteers and patients with slow-transit constipation. Dig Dis Sci 2003;48: 1206–12. [PubMed: 12870774]
Hardcastle JD, Mann CV. Physical factors in the stimulation of colonic peristalsis. Gut 1970;11:41–6. [PMC free article: PMC1411368] [PubMed: 5435268]
Kamath PS, Phillips SF, Zinsmeister AR. Short-chain fatty acids stimulate ileal motility in humans. Gastroenterology 1988;95:1496–502. [PubMed: 3181675]
Kamath PS, Hoepfner MT, Phillips SF. Short-chain fatty acids stimulate motility of the canine ileum. Am J Physiol 1987;253:G427–33. [PubMed: 3661705]
Fukumoto S, Tatewaki M, Yamada T, Fujimiya M, Mantyh C, Voss M, Eubanks S, Harris M, Pappas TN, Takahashi T. Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. Am J Physiol Regul Integr Comp Physiol 2003;284:R1269–76. [PubMed: 12676748]
Spiller RC, Brown ML, Phillips SF. Decreased fluid tolerance, accelerated transit, and abnormal motility of the human colon induced by oleic acid. Gastroenterology 1986;91: 100–7. [PubMed: 3710059]
Dapoigny M, Sarna SK. Effects of physical exercise on colonic motor activity. Am J Physiol 1991;260:G646–52. [PubMed: 2018138]
Holdstock DJ, Misiewicz JJ, Smith T, Rowlands EN. Propulsion (mass movements) in the human colon and its relationship to meals and somatic activity. Gut 1970;11:91–9.10.1136/gut.11.2.91. [PMC free article: PMC1411356] [PubMed: 5441889] [CrossRef]
Flourie B, Phillips S, Richter H, 3rd, Azpiroz F. Cyclic motility in canine colon: responses to feeding and perfusion. Dig Dis Sci 1989;34:1185–92.10.1007/BF01537266. [PubMed: 2752869] [CrossRef]
Karaus M, Sarna SK, Ammon HV, Wienbeck M. Effects of oral laxatives on colonic motor complexes in dogs. Gut 1987;28:1112–9.10.1136/gut.28.9.1112. [PMC free article: PMC1433244] [PubMed: 3678971] [CrossRef]
Auwerda JJ, Bac DJ, Schouten WR. Circadian rhythm of rectal motor complexes. Dis Colon Rectum 2001;44:1328–32.10.1007/BF02234793. [PubMed: 11584210] [CrossRef]
Ronholt C, Rasmussen OO, Christiansen J. Ambulatory manometric recording of anorectal activity. Dis Colon Rectum 1999;42:1551–9.10.1007/BF02236205. [PubMed: 10613473] [CrossRef]
Kumar D, Williams NS, Waldron D, Wingate DL. Prolonged manometric recording of anorectal motor activity in ambulant human subjects: evidence of periodic activity. Gut 1989;30:1007–11.10.1136/gut.30.7.1007. [PMC free article: PMC1434290] [PubMed: 2759480] [CrossRef]
Orkin BHRKK. The rectal motor complex. J Gastrointest Motil 1989;1:5–8.
Orkin BA, Hanson RB, Kelly KA, Phillips SF, Dent J. Human anal motility while fasting, after feeding, and during sleep. Gastroenterology 1991;100:1016–23. [PubMed: 2001798]
Prior A, Fearn UJ, Read NW. Intermittent rectal motor activity: a rectal motor complex? Gut 1991;32:1360–3. [PMC free article: PMC1379168] [PubMed: 1752469]
Ferrara A, Pemberton JH, Levin KE, Hanson RB. Relationship between anal canal tone and rectal motor activity. Dis Colon Rectum 1993;36:337–42.10.1007/BF02053935. [PubMed: 8458258] [CrossRef]
Taylor BM, Beart RW, Jr., Phillips SF. Longitudinal and radial variations of pressure in the human anal sphincter. Gastroenterology 1984;86:693–7. [PubMed: 6698369]
Rao SS, Welcher K. Periodic rectal motor activity: the intrinsic colonic gatekeeper? Am J Gastroenterol 1996;91:890–7. [PubMed: 8633577]
Lynn PA, Blackshaw LA. In vitro recordings of afferent fibres with receptive fields in the serosa, muscle and mucosa of rat colon. J Physiol 1999;518( Pt 1):271–82.10.1111/j.1469-7793.1999.0271r.x. [PMC free article: PMC2269405] [PubMed: 10373708] [CrossRef]
Brierley SM, Jones RC, 3rd, Gebhart GF, Blackshaw LA. Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice. Gastroenterology 2004; 127:166–78.10.1053/j.gastro.2004.04.008. [PubMed: 15236183] [CrossRef]
Lembo T, Munakata J, Naliboff B, Fullerton S, Mayer EA. Sigmoid afferent mechanisms in patients with irritable bowel syndrome. Dig Dis Sci 1997;42:1112–20. [PubMed: 9201070]
Drossman DA, Camilleri M, Mayer EA, Whitehead WE. AGA technical review on irritable bowel syndrome. Gastroenterology 2002;123:2108–31.10.1053/gast.2002.37095. [PubMed: 12454866] [CrossRef]
Mertz HR. Irritable bowel syndrome. N Engl J Med 2003;349:2136–46. [PubMed: 14645642]
Saito YA, Schoenfeld P, Locke GR, 3rd. The epidemiology of irritable bowel syndrome in North America: a systematic review. Am J Gastroenterol 2002;97:1910–5.10.1111/j.1572-0241.2002.05913.x,10.1016/S0002-9270(02)04270-3. [PubMed: 12190153] [CrossRef] [CrossRef]
Chial HJ, Camilleri M. Gender differences in irritable bowel syndrome. J Gend Specif Med 2002;5:37–45. [PubMed: 12078061]
Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA. Functional bowel disorders and functional abdominal pain. Gut 1999;45(Suppl 2):II43–7.10.1136/gut.45.2008.ii43. [PMC free article: PMC1766683] [PubMed: 10457044] [CrossRef]
Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 2006;130:1480–91.10.1053/j.gastro.2005.11.061. [PubMed: 16678561] [CrossRef]
Camilleri M, McKinzie S, Busciglio I, Low PA, Sweetser S, Burton D, Baxter K, Ryks M, Zinsmeister AR. Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2008;6:772–81.10.1016/j.cgh.2008.02.060. [PMC free article: PMC2495078] [PubMed: 18456567] [CrossRef]
Cann PA, Read NW, Brown C, Hobson N, Holdsworth CD. Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns. Gut 1983; 24:405–11.10.1136/gut.24.5.405. [PMC free article: PMC1419989] [PubMed: 6840614] [CrossRef]
Vassallo M, Camilleri M, Phillips SF, Brown ML, Chapman NJ, Thomforde GM. Transit through the proximal colon influences stool weight in the irritable bowel syndrome. Gastroenterology 1992;102:102–8. [PubMed: 1727743]
Horikawa Y, Mieno H, Inoue M, Kajiyama G. Gastrointestinal motility in patients with irritable bowel syndrome studied by using radiopaque markers. Scand J Gastroenterol 1999; 34:1190–5.10.1080/003655299750024698. [PubMed: 10636065] [CrossRef]
Bazzocchi G, Ellis J, Villanueva-Meyer J, Reddy SN, Mena I, Snape WJ, Jr. Effect of eating on colonic motility and transit in patients with functional diarrhea. Simultaneous scintigraphic and manometric evaluations. Gastroenterology 1991;101:1298–306. [PubMed: 1936800]
Deiteren A, Camilleri M, Burton D, McKinzie S, Rao A, Zinsmeister AR. Effect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndrome. Dig Dis Sci 2010;55:384–91.10.1007/s10620-009-1041-8. [PMC free article: PMC2900583] [PubMed: 19949866] [CrossRef]
Manabe N, Wong BS, Camilleri M, Burton D, McKinzie S, Zinsmeister AR. Lower functional gastrointestinal disorders: evidence of abnormal colonic transit in a 287 patient cohort. Neurogastroenterol Motil 2010;22:293–e82.10.1111/j.1365-2982.2009.01442.x. [PMC free article: PMC2852497] [PubMed: 20025692] [CrossRef]
Bouchoucha M, Devroede G, Dorval E, Faye A, Arhan P, Arsac M. Different segmental transit times in patients with irritable bowel syndrome and “normal” colonic transit time: is there a correlation with symptoms? Tech Coloproctol 2006;10:287–96.10.1007/s10151-006-0295-9. [PubMed: 17115321] [CrossRef]
Ritchie J. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 1973;14:125–32.10.1136/gut.14.2.125. [PMC free article: PMC1412559] [PubMed: 4696535] [CrossRef]
Mertz H, Naliboff B, Munakata J, Niazi N, Mayer EA. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 1995;109:40–52.10.1016/0016-5085(95)90267-8. [PubMed: 7797041] [CrossRef]
Bradette M, Delvaux M, Staumont G, Fioramonti J, Bueno L, Frexinos J. Evaluation of colonic sensory thresholds in IBS patients using a barostat. Definition of optimal conditions and comparison with healthy subjects. Dig Dis Sci 1994;39:449–57. [PubMed: 8131679]
Naliboff BD, Munakata J, Fullerton S, Gracely RH, Kodner A, Harraf F, Mayer EA. Evidence for two distinct perceptual alterations in irritable bowel syndrome. Gut 1997;41: 505–12.10.1136/gut.41.4.505. [PMC free article: PMC1891510] [PubMed: 9391250] [CrossRef]
Prior A, Read NW. Reduction of rectal sensitivity and post-prandial motility by granisetron, a 5 HT3-receptor antagonist, in patients with irritable bowel syndrome. Aliment Pharmacol Ther 1993;7:175–80. [PubMed: 8387353]
Prior A, Maxton DG, Whorwell PJ. Anorectal manometry in irritable bowel syndrome: differences between diarrhoea and constipation predominant subjects. Gut 1990;31: 458–62.10.1136/gut.31.4.458. [PMC free article: PMC1378424] [PubMed: 2338274] [CrossRef]
Bassotti G, Chistolini F, Marinozzi G, Morelli A. Abnormal colonic propagated activity in patients with slow transit constipation and constipation-predominant irritable bowel syndrome. Digestion 2003;68:178–83.10.1159/000075554. [PubMed: 14671425] [CrossRef]
Bassotti G, de Roberto G, Castellani D, Sediari L, Morelli A. Normal aspects of colorectal motility and abnormalities in slow transit constipation. World J Gastroenterol 2005;11: 2691–6. [PMC free article: PMC4305899] [PubMed: 15884105]
Hagger R, Kumar D, Benson M, Grundy A. Colonic motor activity in slow-transit idiopathic constipation as identified by 24-h pancolonic ambulatory manometry. Neurogastroenterol Motil 2003;15:515–22.10.1046/j.1365-2982.2003.00435.x. [PubMed: 14507351] [CrossRef]
Rao SS, Sadeghi P, Beaty J, Kavlock R. Ambulatory 24-hour colonic manometry in slow-transit constipation. Am J Gastroenterol 2004;99:2405–16.10.1111/j.1572-0241.2004.40453.x. [PubMed: 15571589] [CrossRef]
Dinning PG, Bampton PA, Andre J, Kennedy ML, Lubowski DZ, King DW, Cook IJ. Abnormal predefecatory colonic motor patterns define constipation in obstructed defecation. Gastroenterology 2004;127:49–56.10.1053/j.gastro.2004.03.066. [PubMed: 15236171] [CrossRef]
Hasler WL, Saad RJ, Rao SS, Wilding GE, Parkman HP, Koch KL, McCallum RW, Kuo B, Sarosiek I, Sitrin MD, Semler JR, Chey WD. Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS. Am J Physiol Gastrointest Liver Physiol 2009;297:G1107–14.10.1152/ajpgi.00136.2009. [PubMed: 19808653] [CrossRef]
Chaudhary NA, Truelove SC. The irritable colon syndrome. A study of the clinical features, predisposing causes, and prognosis in 130 cases. Q J Med 1962;31:307–22. [PubMed: 13878459]
Gwee KA, Graham JC, McKendrick MW, Collins SM, Marshall JS, Walters SJ, Read NW. Psychometric scores and persistence of irritable bowel after infectious diarrhoea. Lancet 1996;347:150–3.10.1016/S0140-6736(96)90341-4. [PubMed: 8544549] [CrossRef]
Gwee KA, Leong YL, Graham C, McKendrick MW, Collins SM, Walters SJ, Underwood JE, Read NW. The role of psychological and biological factors in postinfective gut dysfunction. Gut 1999;44:400–6.10.1136/gut.44.3.400. [PMC free article: PMC1727402] [PubMed: 10026328] [CrossRef]
Halvorson HA, Schlett CD, Riddle MS. Postinfectious irritable bowel syndrome—a meta-analysis. Am J Gastroenterol 2006;101:1894–9; quiz 1942.10.1111/j.1572-0241.2006.00654.x. [PubMed: 16928253] [CrossRef]
McKendrick MW, Read NW. Irritable bowel syndrome--post salmonella infection. J Infect 1994;29:1–3.10.1016/S0163-4453(94)94871-2. [PubMed: 7963621] [CrossRef]
Neal KR, Hebden J, Spiller R. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: postal survey of patients. BMJ 1997;314:779–82. [PMC free article: PMC2126206] [PubMed: 9080994]
Parry SD, Stansfield R, Jelley D, Gregory W, Phillips E, Barton JR, Welfare MR. Does bacterial gastroenteritis predispose people to functional gastrointestinal disorders? A prospective, community-based, case-control study. Am J Gastroenterol 2003;98:1970–5. [PubMed: 14499773]
Mearin F, Perez-Oliveras M, Perello A, Vinyet J, Ibanez A, Coderch J, Perona M. Dyspepsia and irritable bowel syndrome after a Salmonella gastroenteritis outbreak: one-year follow-up cohort study. Gastroenterology 2005;129:98–104.10.1053/j.gastro.2005.04.012. [PubMed: 16012939] [CrossRef]
Bassotti G, Imbimbo BP, Betti C, Dozzini G, Morelli A. Impaired colonic motor response to eating in patients with slow-transit constipation. Am J Gastroenterol 1992;87: 504–8. [PubMed: 1553939]
Bazzocchi G, Ellis J, Villanueva-Meyer J, Jing J, Reddy SN, Mena I, Snape WJ, Jr. Postprandial colonic transit and motor activity in chronic constipation. Gastroenterology 1990;98: 686–93. [PubMed: 2404826]
Reynolds JC, Ouyang A, Lee CA, Baker L, Sunshine AG, Cohen S. Chronic severe constipation. Prospective motility studies in 25 consecutive patients. Gastroenterology 1987;92: 414–20. [PubMed: 3792778]
O’Brien MD, Camilleri M, von der Ohe MR, Phillips SF, Pemberton JH, Prather CM, Wiste JA, Hanson RB. Motility and tone of the left colon in constipation: a role in clinical practice? Am J Gastroenterol 1996;91:2532–8. [PubMed: 8946981]
Bassotti G, Morelli A, Whitehead WE. Abnormal rectosigmoid myoelectric response to eating in patients with severe idiopathic constipation (slow-transit type). Dis Colon Rectum 1992;35:753–6.10.1007/BF02050324. [PubMed: 1643998] [CrossRef]
Bjornsson ES, Chey WD, Hooper F, Woods ML, Owyang C, Hasler WL. Impaired gastrocolonic response and peristaltic reflex in slow-transit constipation: role of 5-HT(3) pathways. Am J Physiol Gastrointest Liver Physiol 2002;283:G400–7. [PubMed: 12121888]
Daly J, Bergin A, Sun WM, Read NW. Effect of food and anti-cholinergic drugs on the pattern of rectosigmoid contractions. Gut 1993;34:799–802.10.1136/gut.34.6.799. [PMC free article: PMC1374265] [PubMed: 8314512] [CrossRef]
Mitolo-Chieppa D, Mansi G, Rinaldi R, Montagnani M, Potenza MA, Genualdo M, Serio M, Mitolo CI, Rinaldi M, Altomare DF, Memeo V. Cholinergic stimulation and nonadrenergic, noncholinergic relaxation of human colonic circular muscle in idiopathic chronic constipation. Dig Dis Sci 1998;43:2719–26. [PubMed: 9881505]
Burleigh DE. Evidence for a functional cholinergic deficit in human colonic tissue resected for constipation. J Pharm Pharmacol 1988;40:55–7. [PubMed: 2896776]
Bassotti G, Chiarioni G, Imbimbo BP, Betti C, Bonfante F, Vantini I, Morelli A, Whitehead WE. Impaired colonic motor response to cholinergic stimulation in patients with severe chronic idiopathic (slow transit type) constipation. Dig Dis Sci 1993;38:1040–5.10.1007/BF01295719. [PubMed: 8508698] [CrossRef]
Hoyle CH, Kamm MA, Lennard-Jones JE, Burnstock G. An in vitro electrophysiological study of the colon from patients with idiopathic chronic constipation. Clin Auton Res 1992;2:327–33.10.1007/BF01824303. [PubMed: 1330123] [CrossRef]
Raethjen J, Pilot MA, Knowles C, Warner G, Anand P, Williams N. Selective autonomic and sensory deficits in slow transit constipation. J Auton Nerv Syst 1997;66:46–52.10.1016/S0165-1838(97)00043-X. [PubMed: 9334992] [CrossRef]
Knowles CH, Scott SM, Wellmer A, Misra VP, Pilot MA, Williams NS, Anand P. Sensory and autonomic neuropathy in patients with idiopathic slow-transit constipation. Br J Surg 1999;86:54–60. [PubMed: 10027360]
Kuiken SD, Lindeboom R, Tytgat GN, Boeckxstaens GE. Relationship between symptoms and hypersensitivity to rectal distension in patients with irritable bowel syndrome. Aliment Pharmacol Ther 2005;22:157–64.10.1111/j.1365-2036.2005.02524.x. [PubMed: 16011674] [CrossRef]
Bouin M, Plourde V, Boivin M, Riberdy M, Lupien F, Laganiere M, Verrier P, Poitras P. Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds. Gastroenterology 2002;122:1771–7.10.1053/gast.2002.33601. [PubMed: 12055583] [CrossRef]
Mayer EA, Raybould HE. Role of visceral afferent mechanisms in functional bowel disorders. Gastroenterology 1990;99:1688–704. [PubMed: 2227282]
Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 1994;107:271–93. [PubMed: 8020671]
Mertz H. Role of the brain and sensory pathways in gastrointestinal sensory disorders in humans. Gut 2002;51 Suppl 1:i29–33.10.1136/gut.51.suppl_1.i29. [PMC free article: PMC1867728] [PubMed: 12077061] [CrossRef]
Camilleri M, Coulie B, Tack JF. Visceral hypersensitivity: facts, speculations, and challenges. Gut 2001;48:125–31.10.1136/gut.48.1.125. [PMC free article: PMC1728183] [PubMed: 11115834] [CrossRef]
Posserud I, Syrous A, Lindstrom L, Tack J, Abrahamsson H, Simren M. Altered rectal perception in irritable bowel syndrome is associated with symptom severity. Gastroenterology 2007;133:1113–23.10.1053/j.gastro.2007.07.024. [PubMed: 17919487] [CrossRef]
Lembo T, Munakata J, Mertz H, Niazi N, Kodner A, Nikas V, Mayer EA. Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome. Gastroenterology 1994;107:1686–96. [PubMed: 7958680]
Whitehead WE, Palsson OS. Is rectal pain sensitivity a biological marker for irritable bowel syndrome: psychological influences on pain perception. Gastroenterology 1998;115: 1263–71.10.1016/S0016-5085(98)70099-X. [PubMed: 9797383] [CrossRef]
Munakata J, Naliboff B, Harraf F, Kodner A, Lembo T, Chang L, Silverman DH, Mayer EA. Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome. Gastroenterology 1997;112:55–63.10.1016/S0016-5085(97)70219-1. [PubMed: 8978343] [CrossRef]
Chang L, Mayer EA, Labus JS, Schmulson M, Lee OY, Olivas TI, Stains J, Naliboff BD. Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome. Am J Physiol Regul Integr Comp Physiol 2006;291:R277–84.10.1152/ajpregu.00729.2005. [PubMed: 16574882] [CrossRef]
Kanazawa M, Palsson OS, Thiwan SI, Turner MJ, van Tilburg MA, Gangarosa LM, Chitkara DK, Fukudo S, Drossman DA, Whitehead WE. Contributions of pain sensitivity and colonic motility to IBS symptom severity and predominant bowel habits. Am J Gastroenterol 2008;103:2550–61.10.1111/j.1572-0241.2008.02066.x. [PMC free article: PMC3855425] [PubMed: 18684175] [CrossRef]
Carrasco GA, Van de Kar LD. Neuroendocrine pharmacology of stress. Eur J Pharmacol 2003;463:235–72.10.1016/S0014-2999(03)01285-8. [PubMed: 12600714] [CrossRef]
Habib KE, Gold PW, Chrousos GP. Neuroendocrinology of stress. Endocrinol Metab Clin North Am 2001;30:695–728; vii–viii.10.1016/S0889-8529(05)70208-5. [PubMed: 11571937] [CrossRef]
Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res 2002;53:865–71.10.1016/S0022-3999(02)00429-4. [PubMed: 12377295] [CrossRef]
Posserud I, Agerforz P, Ekman R, Bjornsson ES, Abrahamsson H, Simren M. Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress. Gut 2004;53:1102–8.10.1136/gut.2003.017962. [PMC free article: PMC1774150] [PubMed: 15247175] [CrossRef]
Elsenbruch S, Lovallo WR, Orr WC. Psychological and physiological responses to postprandial mental stress in women with the irritable bowel syndrome. Psychosom Med 2001; 63:805–13. [PubMed: 11573029]
Dinan TG, Quigley EM, Ahmed SM, Scully P, O’Brien S, O’Mahony L, O’Mahony S, Shanahan F, Keeling PW. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? Gastroenterology 2006;130:304–11.10.1053/j.gastro.2005.11.033. [PubMed: 16472586] [CrossRef]
Elsenbruch S, Orr WC. Diarrhea- and constipation-predominant IBS patients differ in postprandial autonomic and cortisol responses. Am J Gastroenterol 2001;96:460–6.10.1016/S0002-9270(00)02319-4,10.1111/j.1572-0241.2001.03526.x. [PubMed: 11232691] [CrossRef] [CrossRef]
Elsenbruch S, Holtmann G, Oezcan D, Lysson A, Janssen O, Goebel MU, Schedlowski M. Are there alterations of neuroendocrine and cellular immune responses to nutrients in women with irritable bowel syndrome? Am J Gastroenterol 2004;99:703–10.10.1111/j.1572-0241.2004.04138.x. [PubMed: 15089905] [CrossRef]
Fukudo S, Nomura T, Hongo M. Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome. Gut 1998;42:845–9.10.1136/gut.42.6.845. [PMC free article: PMC1727153] [PubMed: 9691924] [CrossRef]
Dickhaus B, Mayer EA, Firooz N, Stains J, Conde F, Olivas TI, Fass R, Chang L, Mayer M, Naliboff BD. Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress. Am J Gastroenterol 2003;98:135–43.10.1016/S0002-9270(02)05824-0,10.1111/j.1572-0241.2003.07156.x. [PubMed: 12526949] [CrossRef] [CrossRef]
Bohmelt AH, Nater UM, Franke S, Hellhammer DH, Ehlert U. Basal and stimulated hypothalamic-pituitary-adrenal axis activity in patients with functional gastrointestinal disorders and healthy controls. Psychosom Med 2005;67:288–94.10.1097/01.psy.0000157064.72831.ba. [PubMed: 15784796] [CrossRef]
Heitkemper M, Jarrett M, Cain K, Shaver J, Bond E, Woods NF, Walker E. Increased urine catecholamines and cortisol in women with irritable bowel syndrome. Am J Gastroenterol 1996;91:906–13. [PubMed: 8633579]
Heitkemper M, Jarrett M, Cain KC, Burr R, Levy RL, Feld A, Hertig V. Autonomic nervous system function in women with irritable bowel syndrome. Dig Dis Sci 2001;46:1276–84. [PubMed: 11414305]
Cain KC, Jarrett ME, Burr RL, Hertig VL, Heitkemper MM. Heart rate variability is related to pain severity and predominant bowel pattern in women with irritable bowel syndrome. Neurogastroenterol Motil 2007;19:110–8.10.1111/j.1365-2982.2006.00877.x. [PubMed: 17244165] [CrossRef]
Chang L, Sundaresh S, Elliott J, Anton PA, Baldi P, Licudine A, Mayer M, Vuong T, Hirano M, Naliboff BD, Ameen VZ, Mayer EA. Dysregulation of the hypothalamic- pituitary-adrenal (HPA) axis in irritable bowel syndrome. Neurogastroenterol Motil 2009; 21:149–59.10.1111/j.1365-2982.2008.01171.x. [PMC free article: PMC2745840] [PubMed: 18684212] [CrossRef]
Tsukamoto K, Nakade Y, Mantyh C, Ludwig K, Pappas TN, Takahashi T. Peripherally administered CRF stimulates colonic motility via central CRF receptors and vagal pathways in conscious rats. Am J Physiol Regul Integr Comp Physiol 2006;290:R1537–41. [PubMed: 16284082]
Tache Y, Monnikes H, Bonaz B, Rivier J. Role of CRF in stress-related alterations of gastric and colonic motor function. Ann N Y Acad Sci 1993;697:233–43.10.1111/j.1749-6632.1993.tb49936.x. [PubMed: 8257013] [CrossRef]
Tache Y, Martinez V, Million M, Wang L. Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors. Am J Physiol Gastrointest Liver Physiol 2001;280:G173–7. [PubMed: 11208537]
Bach DR, Erdmann G, Schmidtmann M, Monnikes H. Emotional stress reactivity in irritable bowel syndrome. Eur J Gastroenterol Hepatol 2006;18:629–36.10.1097/00042737-200606000-00009. [PubMed: 16702852] [CrossRef]
Spetalen S, Sandvik L, Blomhoff S, Jacobsen MB. Rectal visceral sensitivity in women with irritable bowel syndrome without psychiatric comorbidity compared with healthy volunteers. Gastroenterol Res Pract 2009;2009:130684.10.1155/2009/130684. [PMC free article: PMC2748192] [PubMed: 19789637] [CrossRef]
Bennett EJ, Tennant CC, Piesse C, Badcock CA, Kellow JE. Level of chronic life stress predicts clinical outcome in irritable bowel syndrome. Gut 1998;43:256–61.10.1136/gut.43.2.256. [PMC free article: PMC1727204] [PubMed: 10189854] [CrossRef]
Whitehead WE, Crowell MD, Robinson JC, Heller BR, Schuster MM. Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction. Gut 1992;33:825–30.10.1136/gut.33.6.825. [PMC free article: PMC1379344] [PubMed: 1624167] [CrossRef]
Winston JH, Xu GY, Sarna SK. Adrenergic stimulation mediates visceral hypersensitivity to colorectal distension following heterotypic chronic stress. Gastroenterology 2010;138: 294–304 e3.10.1053/j.gastro.2009.09.054. [PMC free article: PMC2813397] [PubMed: 19800336] [CrossRef]
Bradesi S, Schwetz I, Ennes HS, Lamy CM, Ohning G, Fanselow M, Pothoulakis C, McRoberts JA, Mayer EA. Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia. Am J Physiol Gastrointest Liver Physiol 2005;289:G42–53.10.1152/ajpgi.00500.2004. [PubMed: 15746211] [CrossRef]
Yamaguchi-Shima N, Okada S, Shimizu T, Usui D, Nakamura K, Lu L, Yokotani K. Adrenal adrenaline- and noradrenaline-containing cells and celiac sympathetic ganglia are differentially controlled by centrally administered corticotropin-releasing factor and arginine- vasopressin in rats. Eur J Pharmacol 2007;564:94–102.10.1016/j.ejphar.2007.02.021. [PubMed: 17350615] [CrossRef]
Morrison SF, Cao WH. Different adrenal sympathetic preganglionic neurons regulate epinephrine and norepinephrine secretion. Am J Physiol Regul Integr Comp Physiol 2000;279:R1763–75. [PubMed: 11049860]
Choudhury BK, Shi XZ, Sarna SK. Norepinephrine mediates the transcriptional effects of heterotypic chronic stress on colonic motor function. Am J Physiol Gastrointest Liver Physiol 2009. [PMC free article: PMC2697948] [PubMed: 19359422]
Delcroix JD, Valletta JS, Wu C, Hunt SJ, Kowal AS, Mobley WC. NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron 2003;39: 69–84. [PubMed: 12848933]
Leek BF. Abdominal and pelvic visceral receptors. Br Med Bull 1977;33:163–8. [PubMed: 324560]
Sengupta JN, Gebhart GF. Characterization of mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat. J Neurophysiol 1994;71:2046–60. [PubMed: 7931501]
Hebert MA, Serova LI, Sabban EL. Single and repeated immobilization stress differentially trigger induction and phosphorylation of several transcription factors and mitogen-activated protein kinases in the rat locus coeruleus. J Neurochem 2005;95:484–98. [PubMed: 16190871]
Iwaki K, Sukhatme VP, Shubeita HE, Chien KR. Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response. J Biol Chem 1990;265:13809–17. [PubMed: 1696258]
Sabban EL, Kvetnansky R. Stress-triggered activation of gene expression in catecholaminergic systems: dynamics of transcriptional events. Trends Neurosci 2001;24:91–8.10.1016/S0166-2236(00)01687-8. [PubMed: 11164939] [CrossRef]
Ueyama T, Yoshida K, Senba E. Emotional stress induces immediate-early gene expression in rat heart via activation of alpha- and beta-adrenoceptors. Am J Physiol 1999;277: H1553-61. [PubMed: 10516195]
Chitkara DK, van Tilburg MA, Blois-Martin N, Whitehead WE. Early life risk factors that contribute to irritable bowel syndrome in adults: a systematic review. Am J Gastroenterol 2008;103:765–74; quiz 775.10.1111/j.1572-0241.2007.01722.x. [PMC free article: PMC3856200] [PubMed: 18177446] [CrossRef]
Bengtson MB, Ronning T, Vatn MH, Harris JR. Irritable bowel syndrome in twins: genes and environment. Gut 2006;55:1754–9.10.1136/gut.2006.097287. [PMC free article: PMC1856463] [PubMed: 17008364] [CrossRef]
Anand KJ, Runeson B, Jacobson B. Gastric suction at birth associated with long-term risk for functional intestinal disorders in later life. J Pediatr 2004;144:449–54. [PubMed: 15069391]
Drossman DA, Leserman J, Nachman G, Li ZM, Gluck H, Toomey TC, Mitchell CM. Sexual and physical abuse in women with functional or organic gastrointestinal disorders. Ann Intern Med 1990;113:828–33. [PubMed: 2240898]
Koloski NA, Talley NJ, Boyce PM. A history of abuse in community subjects with irritable bowel syndrome and functional dyspepsia: the role of other psychosocial variables. Digestion 2005;72:86–96.10.1159/000087722. [PubMed: 16127275] [CrossRef]
Walker EA, Katon WJ, Roy-Byrne PP, Jemelka RP, Russo J. Histories of sexual victimization in patients with irritable bowel syndrome or inflammatory bowel disease. Am J Psychiatry 1993;150:1502–6. [PubMed: 8379554]
Ross CA. Childhood sexual abuse and psychosomatic symptoms in irritable bowel syndrome. J Child Sex Abus 2005;14:27–38.10.1300/J070v14n01_02. [PubMed: 15914403] [CrossRef]
Salmon P, Skaife K, Rhodes J. Abuse, dissociation, and somatization in irritable bowel syndrome: towards an explanatory model. J Behav Med 2003;26:1–18. [PubMed: 12690943]
Talley NJ, Fett SL, Zinsmeister AR, Melton LJ, 3rd. Gastrointestinal tract symptoms and self-reported abuse: a population-based study. Gastroenterology 1994;107:1040–9. [PubMed: 7926457]
Hislop IG. Childhood deprivation: an antecedent of the irritable bowel syndrome. Med J Aust 1979;1:372–4. [PubMed: 470749]
Al-Chaer ED, Kawasaki M, Pasricha PJ. A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development. Gastroenterology 2000;119:1276–85.10.1053/gast.2000.19576. [PubMed: 11054385] [CrossRef]
Barreau F, Cartier C, Ferrier L, Fioramonti J, Bueno L. Nerve growth factor mediates alterations of colonic sensitivity and mucosal barrier induced by neonatal stress in rats. Gastroenterology 2004;127:524–34.10.1053/j.gastro.2004.05.019. [PubMed: 15300585] [CrossRef]
Coutinho SV, Plotsky PM, Sablad M, Miller JC, Zhou H, Bayati AI, McRoberts JA, Mayer EA. Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am J Physiol Gastrointest Liver Physiol 2002;282:G307–16. [PubMed: 11804852]
Dunlop SP, Jenkins D, Neal KR, Naesdal J, Borgaonker M, Collins SM, Spiller RC. Randomized, double-blind, placebo-controlled trial of prednisolone in post-infectious irritable bowel syndrome. Aliment Pharmacol Ther 2003;18:77–84.10.1046/j.1365-2036.2003.01640.x. [PubMed: 12848628] [CrossRef]
Choudhury BK, Shi XZ, Sarna SK. Gene plasticity in colonic circular smooth muscle cells underlies motility dysfunction in a model of postinfective IBS. Am J Physiol Gastrointest Liver Physiol 2009;296:G632–42.10.1152/ajpgi.90673.2008. [PMC free article: PMC2660181] [PubMed: 19136376] [CrossRef]
Preston DM, Lennard-Jones JE. Severe chronic constipation of young women: ‘idiopathic slow transit constipation’. Gut 1986;27:41–8.10.1136/gut.27.1.41. [PMC free article: PMC1433176] [PubMed: 3949236] [CrossRef]
Knowles CH, Martin JE. Slow transit constipation: a model of human gut dysmotility. Review of possible aetiologies. Neurogastroenterol Motil 2000;12:181–96.10.1046/j.1365-2982.2000.00198.x. [PubMed: 10877606] [CrossRef]
Xiao ZL, Pricolo V, Biancani P, Behar J. Role of progesterone signaling in the regulation of G-protein levels in female chronic constipation. Gastroenterology 2005;128:667–75.10.1053/j.gastro.2004.12.001. [PubMed: 15765402] [CrossRef]
Cong P, Pricolo V, Biancani P, Behar J. Abnormalities of prostaglandins and cyclooxygenase enzymes in female patients with slow-transit constipation. Gastroenterology 2007;133: 445–53.10.1053/j.gastro.2007.05.021. [PubMed: 17681165] [CrossRef]
Cheng L, Pricolo V, Biancani P, Behar J. Overexpression of progesterone receptor B increases sensitivity of human colon muscle cells to progesterone. Am J Physiol Gastrointest Liver Physiol 2008;295:G493–502.10.1152/ajpgi.90214.2008. [PMC free article: PMC2536785] [PubMed: 18776045] [CrossRef]
Lyford GL, He CL, Soffer E, Hull TL, Strong SA, Senagore AJ, Burgart LJ, Young-Fadok T, Szurszewski JH, Farrugia G. Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation. Gut 2002;51:496–501.10.1136/gut.51.4.496. [PMC free article: PMC1773407] [PubMed: 12235070] [CrossRef]
Tong WD, Liu BH, Zhang LY, Zhang SB, Lei Y. Decreased interstitial cells of Cajal in the sigmoid colon of patients with slow transit constipation. Int J Colorectal Dis 2004;19: 467–73.10.1007/s00384-003-0577-x. [PubMed: 15045515] [CrossRef]
Wedel T, Spiegler J, Soellner S, Roblick UJ, Schiedeck TH, Bruch HP, Krammer HJ. Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon. Gastroenterology 2002;123:1459–67.10.1053/gast.2002.36600. [PubMed: 12404220] [CrossRef]
Yu CS, Kim HC, Hong HK, Chung DH, Kim HJ, Kang GH, Kim JC. Evaluation of myenteric ganglion cells and interstitial cells of Cajal in patients with chronic idiopathic constipation. Int J Colorectal Dis 2002;17:253–8.10.1007/s00384-001-0380-5. [PubMed: 12073074] [CrossRef]
Zhang Y, Carmichael SA, Wang XY, Huizinga JD, Paterson WG. Neurotransmission in lower esophageal sphincter of W/Wv mutant mice. Am J Physiol Gastrointest Liver Physiol 2010;298:G14–24.10.1152/ajpgi.00266.2009. [PubMed: 19850967] [CrossRef]
Sarna S, Latimer P, Campbell D, Waterfall WE. Effect of stress, meal and neostigmine on rectosigmoid electrical control activity (ECA) in normals and in irritable bowel syndrome patients. Dig Dis Sci 1982;27:582–91.10.1007/BF01297213. [PubMed: 7083996] [CrossRef]
Goldin E, Karmeli F, Selinger Z, Rachmilewitz D. Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation. Dig Dis Sci 1989;34: 754–7.10.1007/BF01540348. [PubMed: 2469561] [CrossRef]
Lincoln J, Crowe R, Kamm MA, Burnstock G, Lennard-Jones JE. Serotonin and 5- hydroxyindoleacetic acid are increased in the sigmoid colon in severe idiopathic constipation. Gastroenterology 1990;98:1219–25. [PubMed: 1691117]
Tzavella K, Riepl RL, Klauser AG, Voderholzer WA, Schindlbeck NE, Muller-Lissner SA. Decreased substance P levels in rectal biopsies from patients with slow transit constipation. Eur J Gastroenterol Hepatol 1996;8:1207–11.10.1097/00042737-199612000-00014. [PubMed: 8980942] [CrossRef]
Park HJ, Kamm MA, Abbasi AM, Talbot IC. Immunohistochemical study of the colonic muscle and innervation in idiopathic chronic constipation. Dis Colon Rectum 1995;38: 509–13.10.1007/BF02148851. [PubMed: 7736882] [CrossRef]
Koch TR, Carney JA, Go L, Go VL. Idiopathic chronic constipation is associated with decreased colonic vasoactive intestinal peptide. Gastroenterology 1988;94:300–10. [PubMed: 2446945]
Dolk A, Broden G, Holmstrom B, Johansson C, Schultzberg M. Slow transit chronic constipation (Arbuthnot Lane’s disease). An immunohistochemical study of neuropeptide-containing nerves in resected specimens from the large bowel. Int J Colorectal Dis 1990; 5:181–7.10.1007/BF00303272. [PubMed: 2286799] [CrossRef]
Sjolund K, Fasth S, Ekman R, Hulten L, Jiborn H, Nordgren S, Sundler F. Neuropeptides in idiopathic chronic constipation (slow transit constipation). Neurogastroenterol Motil 1997;9:143–50.10.1046/j.1365-2982.1997.d01-46.x. [PubMed: 9347469] [CrossRef]
Cortesini C, Cianchi F, Infantino A, Lise M. Nitric oxide synthase and VIP distribution in enteric nervous system in idiopathic chronic constipation. Dig Dis Sci 1995;40:2450–5.10.1007/BF02063253. [PubMed: 7587830] [CrossRef]
O’Sullivan BP, Freedman SD. Cystic fibrosis. Lancet 2009;373:1891–904. [PubMed: 19403164]
Vencesla A, Fuentes-Prior P, Baena M, Quintana M, Baiget M, Tizzano EF. Severe haemophilia A in a female resulting from an inherited gross deletion and a de novo codon deletion in the F8 gene. Haemophilia 2008;14:1094–8. [PubMed: 18665854]
Steinberg MH. Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches. Sci World J 2008;8:1295–324.10.1100/tsw.2008.157. [PMC free article: PMC5848659] [PubMed: 19112541] [CrossRef]
King Meae. The Genetic Bases of Common Diseases, Oxford University Press. 1992.
Childs B. A logic of disease. In: The Metabolic and Molecular Bases of Inherited Disease, 7th edition, Scriver, CR et al. eds. McGraw-Hill. 1995:229–257.
Howard R, Rabins PV, Seeman MV, Jeste DV. Late-onset schizophrenia and very-late-onset schizophrenia-like psychosis: an international consensus. The International Late-Onset Schizophrenia Group. Am J Psychiatry 2000;157:172–8.10.1176/appi.ajp.157.2.172. [PubMed: 10671383] [CrossRef]
Davis CD, Uthus EO. DNA methylation, cancer susceptibility, and nutrient interactions. Exp Biol Med (Maywood) 2004;229:988–95. [PubMed: 15522834]
Adcock IM, Tsaprouni L, Bhavsar P, Ito K. Epigenetic regulation of airway inflammation. Curr Opin Immunol 2007;19:694–700.10.1016/j.coi.2007.07.016. [PubMed: 17720468] [CrossRef]
Wilson AG. Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases. J Periodontol 2008;79:1514–9.10.1902/jop.2008.080172. [PubMed: 18673005] [CrossRef]
Barnes PJ, Adcock IM, Ito K. Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Respir J 2005;25:552–63.10.1183/09031936.05.00117504. [PubMed: 15738302] [CrossRef]
Hitchler MJ, Domann FE. Metabolic defects provide a spark for the epigenetic switch in cancer. Free Radic Biol Med 2009;47:115–27.10.1016/j.freeradbiomed.2009.04.010. [PMC free article: PMC2728018] [PubMed: 19362589] [CrossRef]
Valinluck V, Sowers LC. Inflammation-mediated cytosine damage: a mechanistic link between inflammation and the epigenetic alterations in human cancers. Cancer Res 2007; 67:5583–6.10.1158/0008-5472.CAN-07-0846. [PubMed: 17575120] [CrossRef]
Petronis A. Human morbid genetics revisited: relevance of epigenetics. Trends Genet 2001; 17:142–6.10.1016/S0168-9525(00)02213-7. [PubMed: 11226607] [CrossRef]
Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1986;1:1077–81.10.1016/S0140-6736(86)91340-1. [PubMed: 2871345] [CrossRef]
Allfrey VG, Faulkner R, Mirsky AE. Acetylation and Methylation of Histones and Their Possible Role in the Regulation of Rna Synthesis. Proc Natl Acad Sci U S A 1964;51: 786–94.10.1073/pnas.51.5.786. [PMC free article: PMC300163] [PubMed: 14172992] [CrossRef]
Pogo BG, Allfrey VG, Mirsky AE. RNA synthesis and histone acetylation during the course of gene activation in lymphocytes. Proc Natl Acad Sci U S A 1966;55:805–12.10.1073/pnas.55.4.805. [PMC free article: PMC224233] [PubMed: 5219687] [CrossRef]
Wu J, Grunstein M. 25 years after the nucleosome model: chromatin modifications. Trends Biochem Sci 2000;25:619–23.10.1016/S0968-0004(00)01718-7. [PubMed: 11116189] [CrossRef]
Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 1997;389:251–60. [PubMed: 9305837]
Bhaumik SR, Smith E, Shilatifard A. Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol 2007;14:1008–16.10.1038/nsmb1337. [PubMed: 17984963] [CrossRef]
Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 2009; 10:32–42.10.1038/nrg2485. [PMC free article: PMC3215088] [PubMed: 19065135] [CrossRef]
Bandyopadhyay K, Baneres JL, Martin A, Blonski C, Parello J, Gjerset RA. Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization. Cell Cycle 2009;8.10.4161/cc.8.17.9416. [PMC free article: PMC3084600] [PubMed: 19652528] [CrossRef]
Bandyopadhyay K, Baneres JL, Martin A, Blonski C, Parello J, Gjerset RA. Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization. Cell Cycle 2009;8:2779–88.10.4161/cc.8.17.9416. [PMC free article: PMC3084600] [PubMed: 19652528] [CrossRef]
Guil S, Esteller M. DNA methylomes, histone codes and miRNAs: tying it all together. Int J Biochem Cell Biol 2009;41:87–95.10.1016/j.biocel.2008.09.005. [PubMed: 18834952] [CrossRef]
Hodl M, Basler K. Transcription in the absence of histone H3.3. Curr Biol 2009;19: 1221–6.10.1016/j.cub.2009.05.048. [PubMed: 19523831] [CrossRef]
Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002;16:6–21.10.1101/gad.947102. [PubMed: 11782440] [CrossRef]
Zilberman D, Gehring M, Tran RK, Ballinger T, Henikoff S. Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription. Nat Genet 2007;39:61–9.10.1038/ng1929. [PubMed: 17128275] [CrossRef]
Deng G, Chen A, Pong E, Kim YS. Methylation in hMLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression. Oncogene 2001;20: 7120–7.10.1038/sj.onc.1204891. [PubMed: 11704838] [CrossRef]
Siedlecki P, Zielenkiewicz P. Mammalian DNA methyltransferases. Acta Biochim Pol 2006;53:245–56. [PubMed: 16582985]
Dong A, Yoder JA, Zhang X, Zhou L, Bestor TH, Cheng X. Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. Nucleic Acids Res 2001;29:439–48.10.1093/nar/29.2.439. [PMC free article: PMC29660] [PubMed: 11139614] [CrossRef]
Kay L. Prevalence, incidence and prognosis of gastrointestinal symptoms in a random sample of an elderly population. Age Ageing 1994;23:146–9.10.1093/ageing/23.2.146. [PubMed: 8023724] [CrossRef]
Agreus L, Svardsudd K, Nyren O, Tibblin G. Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. Gastroenterology 1995;109: 671–80.10.1016/0016-5085(95)90373-9. [PubMed: 7657095] [CrossRef]
Read NW. Diarrhee motrice. Clin Gastroenterol 1986;15:657–86. [PubMed: 3527497]
Rao SS, Holdsworth CD, Read NW. Symptoms and stool patterns in patients with ulcerative colitis. Gut 1988;29:342–5.10.1136/gut.29.3.342. [PMC free article: PMC1433596] [PubMed: 3356365] [CrossRef]
Rao SS, Read NW, Brown C, Bruce C, Holdsworth CD. Studies on the mechanism of bowel disturbance in ulcerative colitis. Gastroenterology 1987;93:934–40. [PubMed: 3653643]
Kern F, Jr., Almy TP, Abbot FK, Bogdonoff MD. The motility of the distal colon in nonspecific ulcerative colitis. Gastroenterology 1951;19:492–503. [PubMed: 14887845]
Spriggs EA, Code CF, Bargen JA, Curtiss RK, Hightower NC, Jr. Motility of the pelvic colon and rectum of normal persons and patients with ulcerative colitis. Gastroenterology 1951;19:480–91. [PubMed: 14887844]
Jalan KN, Walker RJ, Prescott RJ, Butterworth ST, Smith AN, Sircus W. Faecal stasis and diverticular disease in ulcerative colitis. Gut 1970;11:688–96.10.1136/gut.11.8.688. [PMC free article: PMC1553096] [PubMed: 5471035] [CrossRef]
Lennard-Jones JE, Langman MJ, Jones FA. Faecal stasis in proctocolitis. Gut 1962;3: 301–5.10.1136/gut.3.4.301. [PMC free article: PMC1413378] [PubMed: 18668750] [CrossRef]
Annese V, Bassotti G, Napolitano G, Usai P, Andriulli A, Vantrappen G. Gastrointestinal motility disorders in patients with inactive Crohn’s disease. Scand J Gastroenterol 1997; 32:1107–17.10.3109/00365529709002989. [PubMed: 9399391] [CrossRef]
Loening-Baucke V, Metcalf AM, Shirazi S. Anorectal manometry in active and quiescent ulcerative colitis. Am J Gastroenterol 1989;84:892–7. [PubMed: 2756980]
Snape WJ, Jr. The role of a colonic motility disturbance in ulcerative colitis. Keio J Med 1991;40:6–8. [PubMed: 2046212]
Connell AM. The motility of the pelvic colon. II. Paradoxical motility in diarrhoea and constipation. Gut 1962;3:342–8.10.1136/gut.3.4.342. [PMC free article: PMC1413373] [PubMed: 14022607] [CrossRef]
Collins SM. The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders. Gastroenterology 1996;111:1683–99.10.1016/S0016-5085(96)70034-3. [PubMed: 8942751] [CrossRef]
Lium R, Porter JE. Observations on the etiology of ulcerative colitis: III. The distribution of lesions and its possible significance. Am J Pathol 1939;15:73–78 3. [PMC free article: PMC1965014] [PubMed: 19970434]
Jouet P, Sarna SK, Singaram C, Ryan RP, Hillard CJ, Telford GL, Fink J, Henderson JD. Immunocytes and abnormal gastrointestinal motor activity during ileitis in dogs. Am J Physiol 1995;269:G913–24. [PubMed: 8572223]
Otterson MF, Sarna SK, Leming SC, Moulder JE, Fink JG. Effects of fractionated doses of ionizing radiation on colonic motor activity. Am J Physiol 1992;263:G518–26. [PubMed: 1415710]
Belaiche J, Louis E, D’Haens G, Cabooter M, Naegels S, De Vos M, Fontaine F, Schurmans P, Baert F, De Reuck M, Fiasse R, Holvoet J, Schmit A, Van Outryve M. Acute lower gastrointestinal bleeding in Crohn’s disease: characteristics of a unique series of 34 patients. Belgian IBD Research Group. Am J Gastroenterol 1999;94:2177–81.10.1016/S0002-9270(99)00347-0. [PubMed: 10445546] [CrossRef]
Kostka R, Lukas M. Massive, life-threatening bleeding in Crohn’s disease. Acta Chir Belg 2005;105:168–74. [PubMed: 15906908]
Farthing MJ, Lennard-jones JE. Sensibility of the rectum to distension and the anorectal distension reflex in ulcerative colitis. Gut 1978;19:64–9.10.1136/gut.19.1.64. [PMC free article: PMC1411776] [PubMed: 304827] [CrossRef]
Chang L, Munakata J, Mayer EA, Schmulson MJ, Johnson TD, Bernstein CN, Saba L, Naliboff B, Anton PA, Matin K. Perceptual responses in patients with inflammatory and functional bowel disease. Gut 2000;47:497–505.10.1136/gut.47.4.497. [PMC free article: PMC1728092] [PubMed: 10986209] [CrossRef]
Bernstein CN, Niazi N, Robert M, Mertz H, Kodner A, Munakata J, Naliboff B, Mayer EA. Rectal afferent function in patients with inflammatory and functional intestinal disorders. Pain 1996;66:151–61.10.1016/0304-3959(96)03062-X. [PubMed: 8880836] [CrossRef]
Delafoy L, Raymond F, Doherty AM, Eschalier A, Diop L. Role of nerve growth factor in the trinitrobenzene sulfonic acid-induced colonic hypersensitivity. Pain 2003;105:489–97.10.1016/S0304-3959(03)00266-5. [PubMed: 14527709] [CrossRef]
Woolf CJ, Safieh-Garabedian B, Ma QP, Crilly P, Winter J. Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience 1994;62: 327–31.10.1016/0306-4522(94)90366-2. [PubMed: 7530342] [CrossRef]
Sengupta JN, Snider A, Su X, Gebhart GF. Effects of kappa opioids in the inflamed rat colon. Pain 1999;79:175–85.10.1016/S0304-3959(98)00175-4. [PubMed: 10068163] [CrossRef]
Hughes PA, Brierley SM, Martin CM, Brookes SJ, Linden DR, Blackshaw LA. Post- inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses. Gut 2009;58:1333–41.10.1136/gut.2008.170811. [PubMed: 19324867] [CrossRef]
Agostini S, Eutamene H, Broccardo M, Improta G, Petrella C, Theodorou V, Bueno L. Peripheral anti-nociceptive effect of nociceptin/orphanin FQ in inflammation and stress-induced colonic hyperalgesia in rats. Pain 2009;141:292–9.10.1016/j.pain.2008.12.007. [PubMed: 19147291] [CrossRef]
Zhou Q, Price DD, Caudle RM, Verne GN. Visceral and somatic hypersensitivity in TNBS-induced colitis in rats. Dig Dis Sci 2008;53:429–35.10.1007/s10620-007-9881-6. [PMC free article: PMC2807888] [PubMed: 17703363] [CrossRef]
Ohashi K, Sato Y, Iwata H, Kawai M, Kurebayashi Y. Colonic mast cell infiltration in rats with TNBS-induced visceral hypersensitivity. J Vet Med Sci 2007;69:1223–8.10.1292/jvms.69.1223. [PubMed: 18176016] [CrossRef]
Elson CO, Sartor RB, Tennyson GS, Riddell RH. Experimental models of inflammatory bowel disease. Gastroenterology 1995;109:1344–67. [PubMed: 7557106]
Snape WJ, Jr., Williams R, Hyman PE. Defect in colonic smooth muscle contraction in patients with ulcerative colitis. Am J Physiol 1991;261:G987–91. [PubMed: 1685073]
Vrees MD, Pricolo VE, Potenti FM, Cao W. Abnormal motility in patients with ulcerative colitis: the role of inflammatory cytokines. Arch Surg 2002;137:439–45; discussion 445–6.10.1001/archsurg.137.4.439. [PubMed: 11926949] [CrossRef]
Vermillion DL, Huizinga JD, Riddell RH, Collins SM. Altered small intestinal smooth muscle function in Crohn’s disease. Gastroenterology 1993;104:1692–9. [PubMed: 8500728]
Hosseini JM, Goldhill JM, Bossone C, Pineiro-Carrero V, Shea-Donohue T. Progressive alterations in circular smooth muscle contractility in TNBS-induced colitis in rats. Neurogastroenterol Motil 1999;11:347–56.10.1046/j.1365-2982.1999.00165.x. [PubMed: 10520166] [CrossRef]
Kinoshita K, Sato K, Hori M, Ozaki H, Karaki H. Decrease in activity of smooth muscle L-type Ca2+ channels and its reversal by NF-kappaB inhibitors in Crohn’s colitis model. Am J Physiol Gastrointest Liver Physiol 2003;285:G483–93. [PubMed: 12646416]
Kiyosue M, Fujisawa M, Kinoshita K, Hori M, Ozaki H. Different susceptibilities of spontaneous rhythmicity and myogenic contractility to intestinal muscularis inflammation in the hapten-induced colitis. Neurogastroenterol Motil 2006;18:1019–30.10.1111/j.1365-2982.2006.00841.x. [PubMed: 17040413] [CrossRef]
Koch TR, Carney JA, Go VL, Szurszewski JH. Spontaneous contractions and some electrophysiologic properties of circular muscle from normal sigmoid colon and ulcerative colitis. Gastroenterology 1988;95:77–84. [PubMed: 3371626]
Shi XZ, Pazdrak K, Saada N, Dai B, Palade P, Sarna SK. Negative transcriptional regulation of human colonic smooth muscle Cav1.2 channels by p50 and p65 subunits of nuclear factor-kappaB. Gastroenterology 2005;129:1518–32.10.1053/j.gastro.2005.07.058. [PubMed: 16285952] [CrossRef]
Pazdrak K, Shi XZ, Sarna SK. TNFalpha suppresses human colonic circular smooth muscle cell contractility by SP1- and NF-kappaB-mediated induction of ICAM-1. Gastroenterology 2004;127:1096–109. [PubMed: 15480988]
Shi XZ, Lindholm PF, Sarna SK. NF-kappa B activation by oxidative stress and inflammation suppresses contractility in colonic circular smooth muscle cells. Gastroenterology 2003; 124:1369–80. [PubMed: 12730877]
Lee EY, Stenson WF, DeSchryver-Kecskemeti K. Thickening of muscularis mucosae in Crohn’s disease. Mod Pathol 1991;4:87–90. [PubMed: 2020666]
Gaudio E, Taddei G, Vetuschi A, Sferra R, Frieri G, Ricciardi G, Caprilli R. Dextran sulfate sodium (DSS) colitis in rats: clinical, structural, and ultrastructural aspects. Dig Dis Sci 1999;44:1458–75. [PubMed: 10489934]
Shi XZ, Winston JH, Sarna SK. Differential Immune and Genetic Responses in Rat Models of Crohn’s Colitis and Ulcerative Colitis. Am J Physiol Gastrointest Liver Physiol 2010.10.1152/ajpgi.00358.2010. [PMC free article: PMC3025515] [PubMed: 20947704] [CrossRef]
Pravda J. Radical induction theory of ulcerative colitis. World J Gastroenterol 2005;11: 2371–84. [PMC free article: PMC4305621] [PubMed: 15832404]
Garcia-Lafuente A, Antolin M, Guarner F, Crespo E, Salas A, Forcada P, Laguarda M, Gavalda J, Baena JA, Vilaseca J, Malagelada JR. Incrimination of anaerobic bacteria in the induction of experimental colitis. Am J Physiol 1997;272:G10–5. [PubMed: 9038870]
Fukata M, Michelsen KS, Eri R, Thomas LS, Hu B, Lukasek K, Nast CC, Lechago J, Xu R, Naiki Y, Soliman A, Arditi M, Abreu MT. Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol 2005;288:G1055–65.10.1152/ajpgi.00328.2004. [PubMed: 15826931] [CrossRef]
Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004;118:229–41.10.1016/j.cell.2004.07.002. [PubMed: 15260992] [CrossRef]
Araki Y, Sugihara H, Hattori T. In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis. Oncol Rep 2006;16:1357–62. [PubMed: 17089061]
Vetuschi A, Latella G, Sferra R, Caprilli R, Gaudio E. Increased proliferation and apoptosis of colonic epithelial cells in dextran sulfate sodium-induced colitis in rats. Dig Dis Sci 2002;47:1447–57. [PubMed: 12141799]
Kitajima S, Takuma S, Morimoto M. Changes in colonic mucosal permeability in mouse colitis induced with dextran sulfate sodium. Exp Anim 1999;48:137–43.10.1538/expanim.48.137. [PubMed: 10480018] [CrossRef]
Kitajima S, Morimoto M, Sagara E, Shimizu C, Ikeda Y. Dextran sodium sulfate-induced colitis in germ-free IQI/Jic mice. Exp Anim 2001;50:387–95.10.1538/expanim.50.387. [PubMed: 11769541] [CrossRef]
Dieleman LA, Ridwan BU, Tennyson GS, Beagley KW, Bucy RP, Elson CO. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 1994;107:1643–52. [PubMed: 7958674]
Anitha M, Joseph I, Ding X, Torre ER, Sawchuk MA, Mwangi S, Hochman S, Sitaraman SV, Anania F, Srinivasan S. Characterization of fetal and postnatal enteric neuronal cell lines with improvement in intestinal neural function. Gastroenterology 2008;134:1424–35.10.1053/j.gastro.2008.02.018. [PMC free article: PMC2612783] [PubMed: 18471518] [CrossRef]
Villanacci V, Bassotti G, Nascimbeni R, Antonelli E, Cadei M, Fisogni S, Salerni B, Geboes K. Enteric nervous system abnormalities in inflammatory bowel diseases. Neurogastroenterol Motil 2008;20:1009–16.10.1111/j.1365-2982.2008.01146.x. [PubMed: 18492026] [CrossRef]
Belai A, Boulos PB, Robson T, Burnstock G. Neurochemical coding in the small intestine of patients with Crohn’s disease. Gut 1997;40:767–74.10.1136/gut.40.6.767. [PMC free article: PMC1027202] [PubMed: 9245931] [CrossRef]
Ohlsson B, Veress B, Lindgren S, Sundkvist G. Enteric ganglioneuritis and abnormal interstitial cells of Cajal: features of inflammatory bowel disease. Inflamm Bowel Dis 2007;13: 721–6.10.1002/ibd.20095. [PubMed: 17230538] [CrossRef]
Cook MG, Dixon MF. An analysis of the reliability of detection and diagnostic value of various pathological features in Crohn’s disease and ulcerative colitis. Gut 1973;14:255–62.10.1136/gut.14.4.255. [PMC free article: PMC1412589] [PubMed: 4706906] [CrossRef]
Siemers PT, Dobbins WO, 3rd. The Meissner plexus in Crohn’s disease of the colon. Surg Gynecol Obstet 1974;138:39–42. [PubMed: 4809003]
Sanovic S, Lamb DP, Blennerhassett MG. Damage to the enteric nervous system in experimental colitis. Am J Pathol 1999;155:1051–7. [PMC free article: PMC1867003] [PubMed: 10514387]
Collins SM, Blennerhassett PA, Blennerhassett MG, Vermillion DL. Impaired acetylcholine release from the myenteric plexus of Trichinella-infected rats. Am J Physiol 1989;257:G898–903. [PubMed: 2692462]
Davis KA, Masella J, Blennerhassett MG. Acetylcholine metabolism in the inflamed rat intestine. Exp Neurol 1998;152:251–8.10.1006/exnr.1998.6839. [PubMed: 9710525] [CrossRef]
Swain MG, Blennerhassett PA, Collins SM. Impaired sympathetic nerve function in the inflamed rat intestine. Gastroenterology 1991;100:675–82. [PubMed: 1847118]
Lomax AE, Mawe GM, Sharkey KA. Synaptic facilitation and enhanced neuronal excitability in the submucosal plexus during experimental colitis. J Physiol 2005.10.1113/jphysiol.2005.084285. [PMC free article: PMC1464458] [PubMed: 15774518] [CrossRef]
Linden DR, Sharkey KA, Mawe GM. Enhanced excitability of myenteric AH neurones in the inflamed guinea-pig distal colon. J Physiol 2003;547:589–601.10.1113/jphysiol.2002.035147. [PMC free article: PMC2342639] [PubMed: 12562910] [CrossRef]
Goyal RK, Chaudhury A. Mounting evidence against the role of ICC in neurotransmission to smooth muscle in the gut. Am J Physiol Gastrointest Liver Physiol 2010;298:G10–3.10.1152/ajpgi.00426.2009. [PMC free article: PMC2806097] [PubMed: 19892937] [CrossRef]
Painter NBD. Diverticular disease of the colon, a 20th century problem. Clin Gastroenterol 1975;4:2–21. [PubMed: 1109818]
Whiteway J, Morson, BC. Pathology of the aging - diverticular disease. Clin Gastroenterol 1985;14:829–846. [PubMed: 3910310]
Connell AM. Pathogenesis of diverticular disease of the colon. Adv Intern Med 1977;22: 377–95. [PubMed: 842390]
Almy TP, Howell DA. Medical progress. Diverticular disease of the colon. N Engl J Med 1980;302:324–31. [PubMed: 6985709]
Simpson J, Sundler F, Humes DJ, Jenkins D, Scholefield JH, Spiller RC. Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms. Neurogastroenterol Motil 2009;21:847–e58.10.1111/j.1365-2982.2009.01308.x. [PubMed: 19453515] [CrossRef]
Simpson J, Neal KR, Scholefield JH, Spiller RC. Patterns of pain in diverticular disease and the influence of acute diverticulitis. Eur J Gastroenterol Hepatol 2003;15:1005–10.10.1097/00042737-200309000-00011. [PubMed: 12923374] [CrossRef]
Parks TG. Natural history of diverticular disease of the colon. Clin Gastroenterol 1975;4: 53–69. [PubMed: 1109820]
Cortesini C, Pantalone D. Usefulness of colonic motility study in identifying patients at risk for complicated diverticular disease. Dis Colon Rectum 1991;34:339–42.10.1007/BF02050595. [PubMed: 2007352] [CrossRef]
Morson BC. The muscle abnormality in diverticular disease of the colon. Proc R Soc Med 1963;56:798–800. [PMC free article: PMC1897181] [PubMed: 14080071]
Hughes LE. Postmortem survey of diverticular disease of the colon. II. The muscular abnormality of the sigmoid colon. Gut 1969;10:344–51.10.1136/gut.10.5.344. [PMC free article: PMC1552861] [PubMed: 5771666] [CrossRef]
Bassotti G, Battaglia E, De Roberto G, Morelli A, Tonini M, Villanacci V. Alterations in colonic motility and relationship to pain in colonic diverticulosis. Clin Gastroenterol Hepatol 2005;3:248–53.10.1016/S1542-3565(04)00614-7. [PubMed: 15765444] [CrossRef]
Trotman IF, Misiewicz JJ. Sigmoid motility in diverticular disease and the irritable bowel syndrome. Gut 1988;29:218–22.10.1136/gut.29.2.218. [PMC free article: PMC1433293] [PubMed: 3345933] [CrossRef]
Painter NS, Truelove SC. The Intraluminal Pressure Patterns in Diverticulosis of the Colon.3. The effect of prostigmine. Iv. The effect of pethidine and probanthine. Gut 1964; 5:365–73.10.1136/gut.5.4.365. [PMC free article: PMC1413452] [PubMed: 14209923] [CrossRef]
Arfwidsson S, Knock NG, Lehmann L, Winberg T. Pathogenesis of multiple diverticula of the sogmoid colon in diverticular disease. Acta Chir Scand Suppl 1964;63(Suppl 342) 1–68. [PubMed: 14227870]
Brodribb AJ, Humphreys DM. Diverticular disease: three studies. Part I—Relation to other disorders and fibre intake. Br Med J 1976;1:424–5.10.1136/bmj.1.6007.424. [PMC free article: PMC1638933] [PubMed: 1252774] [CrossRef]
Gear JS, Ware A, Fursdon P, Mann JI, Nolan DJ, Brodribb AJ, Vessey MP. Symptomless diverticular disease and intake of dietary fibre. Lancet 1979;1:511–4.10.1016/S0140-6736(79)90942-5. [PubMed: 85104] [CrossRef]
Burkitt DP, Walker AR, Painter NS. Effect of dietary fibre on stools and the transit-times, and its role in the causation of disease. Lancet 1972;2:1408–12.10.1016/S0140-6736(72)92974-1. [PubMed: 4118696] [CrossRef]
Watters DA, Smith AN, Eastwood MA, Anderson KC, Elton RA, Mugerwa JW. Mechanical properties of the colon: comparison of the features of the African and European colon in vitro. Gut 1985;26:384–92.10.1136/gut.26.4.384. [PMC free article: PMC1432523] [PubMed: 3920126] [CrossRef]
Slack WW. The anatomy, pathology, and some clinical features of divericulitis of the colon. Br J Surg 1962;50:185–90.10.1002/bjs.18005022012. [PubMed: 13913774] [CrossRef]
Simpson J, Scholefield JH, Spiller RC. Pathogenesis of colonic diverticula. Br J Surg 2002; 89:546–54.10.1046/j.1365-2168.2002.02076.x. [PubMed: 11972543] [CrossRef]
Smith AN, Shepherd J, Eastwood MA. Pressure changes after balloon distension of the colon wall in diverticular disease. Gut 1981;22:841–4.10.1136/gut.22.10.841. [PMC free article: PMC1419414] [PubMed: 6271651] [CrossRef]
Parks TG. Rectal and colonic studies after resection of the sigmoid for diverticular disease. Gut 1970;11:121–5.10.1136/gut.11.2.121. [PMC free article: PMC1411345] [PubMed: 5441880] [CrossRef]
Beighton PH, Murdoch JL, Votteler T. Gastrointestinal complications of the Ehlers- Danlos syndrome. Gut 1969;10:1004–8.10.1136/gut.10.12.1004. [PMC free article: PMC1553023] [PubMed: 5308459] [CrossRef]
Eliashar R, Sichel JY, Biron A, Dano I. Multiple gastrointestinal complications in Marfan syndrome. Postgrad Med J 1998;74:495–7.10.1136/pgmj.74.874.495. [PMC free article: PMC2360879] [PubMed: 9926129] [CrossRef]
Clemens CH, Samsom M, Roelofs J, van Berge Henegouwen GP, Smout AJ. Colorectal visceral perception in diverticular disease. Gut 2004;53:717–22.10.1136/gut.2003.018093. [PMC free article: PMC1774033] [PubMed: 15082591] [CrossRef]
Humes DJ, Simpson J, Neal KR, Scholefield JH, Spiller RC. Psychological and colonic factors in painful diverticulosis. Br J Surg 2008;95:195–8.10.1002/bjs.5962. [PubMed: 17939130] [CrossRef]
Sarna SK. In vivo myoelectric activity: methods, analysis, and interpretation. Am Physiol Soc 1989.
Sarna SK. Myoelectrical and Contractile Activities of the Gastrointestinal Tract. B.C., Decker, Inc, 2002.
Lembo A, Camilleri M. Chronic constipation. N Engl J Med 2003;349:1360–8.10.1056/NEJMra020995. [PubMed: 14523145] [CrossRef]
Waldron DJ, Kumar D, Hallan RI, Wingate DL, Williams NS. Evidence for motor neuropathy and reduced filling of the rectum in chronic intractable constipation. Gut 1990;31: 1284–8.10.1136/gut.31.11.1284. [PMC free article: PMC1378700] [PubMed: 2253913] [CrossRef]
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