Figure 3.3. Adhesion of fluorescently-labeled platelets to endothelial cells of a mouse cremaster venule, under endotoxin-induced inflammation.

Figure 3.3

Adhesion of fluorescently-labeled platelets to endothelial cells of a mouse cremaster venule, under endotoxin-induced inflammation. Exogenous platelets were labeled with a fluorescein-based dye (green) and infused into a recipient mouse for monitoring in vivo during intravital microscopy (upper panel); dashed lines outlined the microvascular walls. Lower panel depicts red fluorescent staining of platelets in excised tissues, demonstrating endogenous (red) and exogenous (red+green, appearing yellow) labeled platelets. Approximately 8% of the total adherent platelets are exogenous, comparable to the percentage in peripheral blood (10%). Bar = 40 μm. Figure reproduced from reference [134], with permission.

From: Chapter 3, Platelet Adhesion to Vascular Walls

Cover of Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis
Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis.
Rumbaut RE, Thiagarajan P.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2010 by Morgan & Claypool Life Sciences.

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