Figure 1.4. The volume filtered from an occluded vessel segment is indicated by the distance a marker cell travels (Δx) in a given amount of time (Δt).

Figure 1.4

The volume filtered from an occluded vessel segment is indicated by the distance a marker cell travels (Δx) in a given amount of time (Δt). The rate of marker cell movement will be a function of distance from the occluding rod – those furthest from the occluder will travel the fastest; those nearest will travel the slowest; within 60 μm of the occluder they may not move at all and the assumption of a circular geometry is likely in error. At the first time point, T1, in a vessel of radius, r, the marker cell is a distance xo from the occluding rod. The volume of the cylinder at this time is V1 = πr2xo. If the vessel wall is permeable to water and a period of time is allowed to elapse, Δt == (t1t2), the marker cell will move a distance Δx. The filtered volume per unit surface area for a cylinder, Jv/S is given as (Δxt)(1/xo)(r/2).

From: Chapter 1, Fluid Movement Across the Endothelial Barrier

Cover of Capillary Fluid Exchange
Capillary Fluid Exchange: Regulation, Functions, and Pathology.
Scallan J, Huxley VH, Korthuis RJ.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2010 by Morgan & Claypool Life Sciences.

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