FIGURE 10.1. Routes of solute exchange across the inflamed endothelial barrier.

FIGURE 10.1

Routes of solute exchange across the inflamed endothelial barrier. Albumin and other plasma proteins can gain access to the interstitial compartment from plasma via either a paracellular ( junctional) or intracellular (vesicular) transport pathway. The integrity of the adherens junction is regulated by junctional proteins such as VE-cadherin, which is linked to actin components of the cytoskeleton via the catenins. The paracellular pathway includes plasmalemmal vesicles that shuttle plasma proteins between the blood and interstitial interface of the endothelial cell, as well as patent channels formed by the fusion of vesicle clusters called vesiculovacuolar organelles (VVO).

From: Chapter 10, Endothelial Barrier Dysfunction

Cover of Inflammation and the Microcirculation
Inflammation and the Microcirculation.
Granger DN, Senchenkova E.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2010 by Morgan & Claypool Life Sciences.

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