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Kuhn CM, Koob GF, editors. Advances in the Neuroscience of Addiction. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2010.

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Advances in the Neuroscience of Addiction. 2nd edition.

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The Editors

Cynthia Kuhn, Ph.D., is a professor in the Department of Pharmacology and Cancer Biology at Duke University Medical Center. She earned her B.A. in biology at Stanford University and her Ph.D. in pharmacology at Duke. She has been a faculty member at Duke since 1978. She has studied the effect of addictive drugs on the developing brain, and the interaction of hormonal state and the effects of addictive drugs throughout her career. Dr. Kuhn's work has identified the contribution of enhanced dopaminergic function to the addiction risk for adolescents and females. She has received continuous funding from the National Institute of Drug Abuse to study the effects of cocaine on women and adolescent animals and has published more than 250 scientific papers. She has trained 7 predoctoral, 10 postdoctoral, and more than 50 undergraduate students.

In addition to her research activities, Dr. Kuhn is extremely active in teaching for both professional and lay audiences. She has taught pharmacology (drug abuse, endocrinology) in the medical school curriculum for 25 years and teaches an undergraduate course at Duke entitled “Drugs and the Brain.” She is a member of the Translational Prevention Research Center at Duke and is active nationally in drug abuse education for students, teachers, prevention specialists and treatment providers. She has coauthored three books for the lay public: Buzzed: The Straight Facts About the Most Used and Abused Drugs From Alcohol to Ecstasy (Norton, 2008), Just Say Know: Talking with Kids about Drugs and Alcohol (Norton, 2002), and Pumped: Straight Facts for Athletes About Drugs, Supplements and Training (Norton, 2000). She lectures to lay audiences including parents, students, church groups and others.

George F. Koob, Ph.D., is a professor and chair of the Committee on the Neurobiology of Addictive Disorders at The Scripps Research Institute, adjunct professor in the Departments of Psychology and Psychiatry, and adjunct professor in the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California, San Diego. Dr. Koob received his bachelor of science degree from Pennsylvania State University and his Ph.D. in Behavioral Physiology from The Johns Hopkins University. An authority on addiction and stress, Dr. Koob has published over 670 scientific papers and has received continuous funding for his research from the National Institutes of Health, including the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA). He is director of the NIAAA Alcohol Research Center at The Scripps Research Institute, consortium coordinator for NIAAAs multi-center Integrative Neuroscience Initiative on Alcoholism, and co-director of the Pearson Center for Alcoholism and Addiction Research. He has trained 10 predoctoral and 64 postdoctoral fellows. Dr. Koob is editor-in-chief USA for the journal Pharmacology Biochemistry and Behavior and editor-in-chief for the Journal of Addiction Medicine. He won the Daniel Efron Award for excellence in research from the American College of Neuropsychopharmacology, was

honored as a Highly Cited Researcher from the Institute for Scientific Information, was presented with the Distinguished Investigator Award from the Research Society on Alcoholism, and won the Mark Keller Award from NIAAA. He published a landmark book in 2006 with his colleague Dr. Michel Le Moal, Neurobiology of Addiction (Academic Press-Elsevier, Amsterdam).

Dr. Koob's research interests have been directed at the neurobiology of emotion, with a focus on the theoretical constructs of reward and stress. He has made contributions to our understanding of the anatomical connections of the emotional systems and the neurochemistry of emotional function. Dr. Koob has identified afferent and efferent connections of the basal forebrain (extended amygdala) in the region of the nucleus accumbens, bed nucleus of the stria terminalis, and central nucleus of the amygdala in motor activation, reinforcement mechanisms, behavioral responses to stress, drug self-administration, and the neuroadaptation associated with drug dependence.

Dr. Koob is one of the world's authorities on the neurobiology of drug addiction. He has contributed to our understanding of the neurocircuitry associated with the acute reinforcing effects of drugs of abuse and more recently on the neuroadaptations of these reward circuits associated with the transition to dependence. He has validated key animal models for dependence associated with drugs of abuse and has begun to explore a key role of anti-reward systems in the development of dependence.

Dr. Koob's work with the neurobiology of stress includes the characterization of behavioral functions in the central nervous system for catecholamines, opioid peptides, and corticotropin-releasing factor. Corticotropin-releasing factor, in addition to its classical hormonal functions in the hypothalamic-pituitary-adrenal axis, is also located in extrahypothalamic brain structures and may have an important role in brain emotional function. Recent use of specific corticotropin-releasing factor antagonists suggests that endogenous brain corticotropin-releasing factor may be involved in specific behavioral responses to stress, the psychopathology of anxiety and affective disorders, and drug addiction. Dr. Koob also has characterized functional roles for other stress-related neurotransmitters/neuroregulators such as norepinephrine, vasopressin, hypocretin (orexin), neuropeptide Y, and neuroactive steroids.

The identification of specific neurochemical systems within the basal forebrain system of the extended amygdala involved in motivation has significant theoretical and heuristic impact. From a theoretical perspective, identification of a role for dopaminergic, opioidergic, GABAergic, glutamatergic, and corticotropin-releasing factor systems in excessive drug taking provides a neuropharmacologic basis for the allostatic changes hypothesized to drive the process of pathology associated with addiction, anxiety, and depression. From a heuristic perspective, these findings provide a framework for further molecular, cellular, and neurocircuit research that will identify the basis for individual differences in vulnerability to pathology.

Copyright © 2010 by Taylor and Francis Group, LLC.
Bookshelf ID: NBK53353

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