Figure 8.4. Arachidonic acid – TX /PGI pathway.

Figure 8.4

Arachidonic acid – TX /PGI pathway. Phospholiase A2 (PLA2) and phospholipase C (PLC) liberate arachidonic acid (AA) from membrane lipid of placental syncytiotrophoblasts. Cycloxygenase (COX) produces PGG2 and PGH2 from AA. Subsequently, thromboxane (TXA2), prostacyclin (PGI2), and prostaglandins (PGs) are produced via corresponding synthases, TX synthase (TXS), PGI2 synthase (PGIS), and prostaglandin isomerases, respectively. The function of TXA2 and PGI2 is opposite. TXA2 binds to its TP receptor inducing vasoconstriction and PGI2 binds to its IP receptor causing vasodilation.

From: Chapter 8, Vasoactivators and Placental Vasoactivity

Cover of Vascular Biology of the Placenta
Vascular Biology of the Placenta.
Wang Y, Zhao S.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2010 by Morgan & Claypool Life Sciences.

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