American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.

Kotwicki R, Harvey PD. Systematic study of structured diagnostic prodecures in outpatient psychiatric rehabilitation: a three-year, three-cohort study of the stability of psychiatric diagnoses. Innov Clin Neurosci. 2013 May–Jun;10(5–6):14–9. PMID: 23882436. [PMC free article: PMC3719455] [PubMed: 23882436]

Ferrari A, Baxter A, Whiteford H. A systematic review of the global distribution and availability of prevalence data for bipolar disorder. J Affect Disord. 2011;134(1–3):1–13. [PubMed: 21131055]

Gum A, King-Kallimanis B, Kohn R. Prevalence of mood, anxiety, and substance-abuse disorders for older Americans in the national comorbidity survey-replication. Am J Geriatr Psychiatry. 2009;17:769–81. [PubMed: 19700949]

Samame C, Martino DJ, Strejilevich SA. Social cognition in euthymic bipolar disorder: systematic review and meta-analytic approach. Acta Psychiatr Scand. 2012;125(4):266–80. [PubMed: 22211280]

Sole B, Martinez-Aran A, Torrent C, et al Are bipolar II patients cognitively impaired? A systematic review. Psychol Med. 2011;41(9):1791–803. [PubMed: 21275085]

Schaffer A, Isometsa ET, Tondo L, et al Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: Part I of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder. Aust N Z J Psychiatry.49(9):785–802. PMID: 26185269. [PMC free article: PMC5116383] [PubMed: 26185269]

Merikangas K, Akiskal HS, Angst J, et al Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry. 2007 May;64(5):543–52. PMID: 17485606. [PMC free article: PMC1931566] [PubMed: 17485606]

Brady KT, Sonne S. The relationship between substance abuse and bipolar disorder. J Clin Psychiatry. 1995;56(Suppl 3):19–24. PMID: 7883738 [PubMed: 7883738]

Moher D, Liberati A, Tetzlaff J, et al Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009 Oct;62(10):1006–12. doi: 10.1016/j.jclinepi.2009.06.005. PMID: 19631508. [PubMed: 19631508] [CrossRef]

Higgins JPT, Altman D, Sterne J. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions: Version 5.1.0. The Cochrane Collaboration; 2011.

Viswanath B, Jose SP, Squassina A, et al Cellular models to study bipolar disorder: A systematic review. J Affect Disord. 2015 11 Jun;184:36–50. doi: http://dx​.doi.org/10​.1016/j.jad.2015.05.037. PMID: 2015111614. [PubMed: 26070045]

Langan D, Higgins JP, Simmonds M. Comparative performance of heterogeneity variance estimators in meta-analysis: a review of simulation studies. Res Synth Methods. 2016 Apr 06 doi: 10.1002/jrsm.1198. PMID: 27060925. [PubMed: 27060925] [CrossRef]

Sidik K, Jonkman JN. A comparison of heterogeneity variance estimators in combining results of studies. Stat Med. 2007 Apr 30;26(9):1964–81. doi: 10.1002/sim.2688. PMID: 16955539. [PubMed: 16955539] [CrossRef]

IntHout J, Ioannidis JP, Borm GF. The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method. BMC Med Res Methodol. 2014 Feb 18;14:25. doi: 10.1186/1471-2288-14-25. PMID: 24548571. [PMC free article: PMC4015721] [PubMed: 24548571] [CrossRef]

Rover C, Knapp G, Friede T. Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few studies. BMC Med Res Methodol. 2015 Nov 14;15:99. doi: 10.1186/s12874-015-0091-1. PMID: 26573817. [PMC free article: PMC4647507] [PubMed: 26573817] [CrossRef]

Gonnermann A, Framke T, Grosshennig A, et al No solution yet for combining two independent studies in the presence of heterogeneity. Stat Med. 2015 Jul 20;34(16):2476–80. doi: 10.1002/sim.6473. PMID: 26040434. [PMC free article: PMC4471592] [PubMed: 26040434] [CrossRef]

Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw. 2010;36(3):1–48.

R Core Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2016.

Fu R, Gartlehner G, Grant M, et al Conducting quantitative synthesis when comparing medical interventions: AHRQ and the Effective Health Care Program. J Clin Epidemiol. 2011 Nov;64(11):1187–97. PMID: 21477993. [PubMed: 21477993]

Berkman ND, Lohr K, Ansari M, et al Grading the strength of a body of evidence when assessing health care interventions for the effective health care program of the Agency for Healthcare Research and Quality: An update. . Rockville, MD: Agency for Healthcare Research and Quality; 2013. (vol. AHRQ Publication No. 13(14)-EHC 130-EF).

Atkins D, Chang S, Gartlehner G, et al Assessing the applicability of studies when comparing medical interventions Agency for Healthcare Research and Quality. January 2011. [PubMed: 21433409]

Leon AC, Mallinckrodt CH, Chuang-Stein C, et al Attrition in Randomized Controlled Clinical Trials: Methodological Issues in Psychopharmacology. Biol Psychiatry. 2006 6/1/;59(11):1001–5. doi: http://dx​.doi.org/10​.1016/j.biopsych.2005.10.020. [PubMed: 16503329]

Little RJ, D’Agostino R, Cohen ML, et al The Prevention and Treatment of Missing Data in Clinical Trials. N Engl J Med. 2012;367(14):1355–60. doi: doi:10.1056/NEJMsr1203730. PMID: 23034025. [PMC free article: PMC3771340] [PubMed: 23034025] [CrossRef]

McIntyre RS, Cohen M, Zhao J, et al Asenapine in the treatment of acute mania in bipolar I disorder: a randomized, double-blind, placebo-controlled trial. J Affect Disord. 2010 Apr;122(1–2):27–38. doi: http://dx​.doi.org/10​.1016/j.jad.2009.12.028. PMID: 20096936. [PubMed: 20096936]

McIntyre RS, Cohen M, Zhao J, et al A 3-week, randomized, placebo-controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states. [Erratum appears in Bipolar Disord. 2010 May;12(3):350]. Bipolar Disord. 2009 Nov;11(7):673–86. doi: http://dx​.doi.org/10​.1111/j.1399-5618.2009.00748.x. PMID: 19839993. [PubMed: 19839993]

Landbloom RL, Mackle M, Wu X, et al Asenapine: Efficacy and safety of 5 and 10mg bid in a 3-week, randomized, double-blind, placebo-controlled trial in adults with a manic or mixed episode associated with bipolar I disorder. J Affect Disord. 2016 Jan 15;190:103–10. doi: http://dx​.doi.org/10​.1016/j.jad.2015.06.059. PMID: 26496015. [PubMed: 26496015]

Calabrese JR, Keck PE, Jr., Starace A, et al Efficacy and safety of low- and high-dose cariprazine in acute and mixed mania associated with bipolar I disorder: a double-blind, placebo-controlled study. J Clin Psychiatry. 2015 Mar;76(3):284–92. doi: http://dx​.doi.org/10.4088/JCP.14m09081. PMID: 25562205. [PubMed: 25562205]

Durgam S, Starace A, Li D, et al The efficacy and tolerability of cariprazine in acute mania associated with bipolar I disorder: A phase II trial. Bipolar Disord. 2015 Feb;17(1):63–75. doi: http://dx​.doi.org/10.1111/bdi.12238. PMID: 25056368 (pubmed) 2014-30788-001(Psychinfo). [PubMed: 25056368]

Sachs GS, Greenberg WM, Starace A, et al Cariprazine in the treatment of acute mania in bipolar I disorder: a double-blind, placebo-controlled, phase III trial. J Affect Disord. 2015 Mar 15;174:296–302. doi: http://dx​.doi.org/10​.1016/j.jad.2014.11.018. PMID: 25532076. [PubMed: 25532076]

Katagiri H, Takita Y, Tohen M, et al Efficacy and safety of olanzapine in the treatment of Japanese patients with bipolar I disorder in a current manic or mixed episode: a randomized, double-blind, placebo- and haloperidol-controlled study. J Affect Disord. 2012 Feb;136(3):476–84. doi: http://dx​.doi.org/10​.1016/j.jad.2011.10.045. PMID: 22134043. [PubMed: 22134043]

McIntyre RS. Aripiprazole for the maintenance treatment of bipolar I disorder: A review. Clin Ther. 2010;32 Suppl 1:S32–8. doi: http://dx​.doi.org/10​.1016/j.clinthera.2010.01.022. PMID: 20152551. [PubMed: 20152551]

Tohen M, Vieta E, Goodwin GM, et al Olanzapine versus divalproex versus placebo in the treatment of mild to moderate mania: a randomized, 12-week, double-blind study. J Clin Psychiatry. 2008 Nov;69(11):1776–89. PMID: 19014751. [PubMed: 19014751]

Tohen M, Jacobs TG, Grundy SL, et al Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group. [Erratum appears in Arch Gen Psychiatry 2002 Jan;59(1):91]. Arch Gen Psychiatry. 2000 Sep;57(9):841–9. PMID: 10986547. [PubMed: 10986547]

Vieta E, Nuamah IF, Lim P, et al A randomized, placebo- and active-controlled study of paliperidone extended release for the treatment of acute manic and mixed episodes of bipolar I disorder. Bipolar Disord. 2010 May;12(3):230–43. doi: http://dx​.doi.org/10​.1111/j.1399-5618.2010.00815.x. PMID: 20565430. [PubMed: 20565430]

Bowden CL, Grunze H, Mullen J, et al A randomized, double-blind, placebo-controlled efficacy and safety study of quetiapine or lithium as monotherapy for mania in bipolar disorder. J Clin Psychiatry. 2005 Jan;66(1):111–21. PMID: 15669897. [PubMed: 15669897]

McIntyre RS, Brecher M, Paulsson B, et al Quetiapine or haloperidol as monotherapy for bipolar mania-a 12-week, double-blind, randomised, parallel-group, placebo-controlled trial. Eur Neuropsychopharmacol. 2005 Oct;15(5):573–85. PMID: 16139175. [PubMed: 16139175]

Cutler AJ, Datto C, Nordenhem A, et al Extended-release quetiapine as monotherapy for the treatment of adults with acute mania: a randomized, double-blind, 3-week trial. Clin Ther. 2011 Nov;33(11):1643–58. doi: http://dx​.doi.org/10​.1016/j.clinthera.2011.10.002. PMID: 22054797. [PubMed: 22054797]

McElroy SL, Martens BE, Winstanley EL, et al Placebo-controlled study of quetiapine monotherapy in ambulatory bipolar spectrum disorder with moderate-to-severe hypomania or mild mania. J Affect Disord. 2010 Jul;124(1–2):157–63. doi: http://dx​.doi.org/10​.1016/j.jad.2009.11.014. PMID: 19963274. [PubMed: 19963274]

Khanna S, Vieta E, Lyons B, et al Risperidone in the treatment of acute mania. Br J Psychiatry. 2005 2005;187(3):229–34. doi: http://dx​.doi.org/10.1192/bjp.187.3.229. PMID: 16135859. [PubMed: 16135859]

Smulevich AB, Khanna S, Eerdekens M, et al Acute and continuation risperidone monotherapy in bipolar mania: a 3-week placebo-controlled trial followed by a 9-week double-blind trial of risperidone and haloperidol. Eur Neuropsychopharmacol. 2005 Jan;15(1):75–84. PMID: 15572276. [PubMed: 15572276]

Potkin SG, Keck PE, Jr., Segal S, et al Ziprasidone in acute bipolar mania: a 21-day randomized, double-blind, placebo-controlled replication trial. J Clin Psychopharmacol. 2005 Aug;25(4):301–10. PMID: 16012271. [PubMed: 16012271]

Keck PE, Jr., Versiani M, Potkin S, et al Ziprasidone in the treatment of acute bipolar mania: a three-week, placebo-controlled, double-blind, randomized trial. Am J Psychiatry. 2003 Apr;160(4):741–8. PMID: 12668364. [PubMed: 12668364]

Tohen M, Baker RW, Altshuler LL, et al Olanzapine versus divalproex in the treatment of acute mania. [Erratum appears in Am J Psychiatry. 2005 Feb;7(1):102]. Am J Psychiatry. 2002 Jun;159(6):1011–7. PMID: 12042191. [PubMed: 12042191]

Zajecka JM, Weisler R, Sachs G, et al A comparison of the efficacy, safety, and tolerability of divalproex sodium and olanzapine in the treatment of bipolar disorder. J Clin Psychiatry. 2002 Dec;63(12):1148–55. PMID: 12523875. [PubMed: 12523875]

Xu L, Lu Y, Yang Y, et al Olanzapine-valproate combination versus olanzapine or valproate monotherapy in the treatment of bipolar imania: A randomized controlled study in a chinese population group. Neuropsychiatr Dis Treat. 2015 25 May;11:1265–71. doi: http://dx​.doi.org/10.2147/NDT.S81146. PMID: 26060401 (pubmed) 2015078440 (embase). [PMC free article: PMC4450656] [PubMed: 26060401]

Vieta E, Bourin M, Sanchez R, et al Effectiveness of aripiprazole v. haloperidol in acute bipolar mania: double-blind, randomised, comparative 12-week trial. Br J Psychiatry. 2005 Sep;187:235–42. PMID: 16135860. [PubMed: 16135860]

Young AH, Oren DA, Lowy A, et al Aripiprazole monotherapy in acute mania: 12-week randomised placebo- and haloperidol-controlled study. Br J Psychiatry. 2009 Jan;194(1):40–8. doi: http://dx​.doi.org/10​.1192/bjp.bp.108.049965. PMID: 19118324. [PubMed: 19118324]

Kanba S, Kawasaki H, Ishigooka J, et al A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole for the treatment of acute manic or mixed episodes in Asian patients with bipolar I disorder (the AMAZE study). World J Biol Psychiatry. 2014 2014;15(2):113–21. doi: http://dx​.doi.org/10​.3109/15622975.2012.669047. PMID: 22540407. [PubMed: 22540407]

Sachs G, Sanchez R, Marcus R, et al Aripiprazole in the treatment of acute manic or mixed episodes in patients with bipolar I disorder: a 3-week placebo-controlled study. J Psychopharmacol. 2006 Jul;20(4):536–46. PMID: 16401666. [PubMed: 16401666]

Jeong HG, Lee MS, Ko YH, et al Combination treatment with aripiprazole and valproic acid for acute mania: an 8-week, single-blind, randomized controlled trial. Clin Neuropharmacol . 2012 May–Jun;35(3):97–102. doi: http://dx​.doi.org/10​.1097/WNF.0b013e3182560401. PMID: 22592508. [PubMed: 22592508]

Vieta E, T’Joen C, McQuade RD, et al Efficacy of adjunctive aripiprazole to either valproate or lithium in bipolar mania patients partially nonresponsive to valproate/lithium monotherapy: a placebo-controlled study. Am J Psychiatry. 2008 Oct;165(10):1316–25. doi: http://dx​.doi.org/10​.1176/appi.ajp.2008.07101560. PMID: 18381903. [PubMed: 18381903]

Suppes T, Eudicone J, McQuade R, et al Efficacy and safety of aripiprazole in subpopulations with acute manic or mixed episodes of bipolar I disorder. J Affect Disord. 2008 Apr;107(1–3):145–54. PMID: 17904226. [PubMed: 17904226]

Sachs GS, Gaulin BD, Gutierrez-Esteinou R, et al Antimanic response to aripiprazole in bipolar I disorder patients is independent of the agitation level at baseline. J Clin Psychiatry. 2007 Sep;68(9):1377–83. PMID: 17915976. [PubMed: 17915976]

El Mallakh RS, Vieta E, Rollin L, et al A comparison of two fixed doses of aripiprazole with placebo in acutely relapsed, hospitalized patients with bipolar disorder I (manic or mixed) in subpopulations (CN138-007). Eur Neuropsychopharmacol. 2010 Nov;20(11):776–83. doi: http://dx​.doi.org/10​.1016/j.euroneuro.2010.07.003. PMID: 20728318. [PubMed: 20728318]

Keck PE, Jr., Calabrese JR, McQuade RD, et al A randomized, double-blind, placebo-controlled 26-week trial of aripiprazole in recently manic patients with bipolar I disorder. J Clin Psychiatry. 2006 Apr;67(4):626–37. PMID: 16669728. [PubMed: 16669728]

Keck PE, Jr., Marcus R, Tourkodimitris S, et al A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania. Am J Psychiatry. 2003 Sep;160(9):1651–8. PMID: 12944341. [PubMed: 12944341]

Keck PE, Orsulak PJ, Cutler AJ, et al Aripiprazole monotherapy in the treatment of acute bipolar I mania: a randomized, double-blind, placebo- and lithium-controlled study. J Affect Disord. 2009 Jan;112(1–3):36–49. doi: http://dx​.doi.org/10​.1016/j.jad.2008.05.014. PMID: 18835043. [PubMed: 18835043]

Szegedi A, Calabrese JR, Stet L, et al Asenapine as adjunctive treatment for acute mania associated with bipolar disorder: results of a 12-week core study and 40-week extension. J Clin Psychopharmacol. 2012 Feb;32(1):46–55. doi: http://dx​.doi.org/10​.1097/JCP.0b013e31823f872f. PMID: 22198448. [PubMed: 22198448]

Berk M, Ichim L, Brook S. Olanzapine compared to lithium in mania: a double-blind randomized controlled trial. Int Clin Psychopharmacol. 1999 Nov;14(6):339–43. PMID: 10565800. [PubMed: 10565800]

Niufan G, Tohen M, Qiuqing A, et al Olanzapine versus lithium in the acute treatment of bipolar mania: a double-blind, randomized, controlled trial. J Affect Disord. 2008 Jan;105(1–3):101–8. PMID: 17531327. [PubMed: 17531327]

Perlis RH, Baker RW, Zarate CA, Jr., et al Olanzapine versus risperidone in the treatment of manic or mixed States in bipolar I disorder: a randomized, double-blind trial. J Clin Psychiatry. 2006 Nov;67(11):1747–53. PMID: 17196055. [PubMed: 17196055]

Revicki DA, Paramore LC, Sommerville KW, et al Divalproex sodium versus olanzapine in the treatment of acute mania in bipolar disorder: health-related quality of life and medical cost outcomes. J Clin Psychiatry. 2003 Mar;64(3):288–94. PMID: 12716270. [PubMed: 12716270]

Shafti SS. Olanzapine vs. lithium in management of acute mania. J Affect Disord. 2010 May;122(3):273–6. doi: http://dx​.doi.org/10​.1016/j.jad.2009.08.013. PMID: 19740546. [PubMed: 19740546]

Shi L, Namjoshi MA, Zhang F, et al Olanzapine versus haloperidol in the treatment of acute mania: clinical outcomes, health-related quality of life and work status. Int Clin Psychopharmacol. 2002 Sep;17(5):227–37. PMID: 12177585. [PubMed: 12177585]

Tohen M, Chengappa KN, Suppes T, et al Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy. Arch Gen Psychiatry. 2002 Jan;59(1):62–9. PMID: 11779284. [PubMed: 11779284]

Tohen M, Goldberg JF, Gonzalez-Pinto Arrillaga AM, et al A 12-week, double-blind comparison of olanzapine vs haloperidol in the treatment of acute mania. Arch Gen Psychiatry. 2003 Dec;60(12):1218–26. PMID: 14662554. [PubMed: 14662554]

Conus P, Berk M, Cotton SM, et al Olanzapine or chlorpromazine plus lithium in first episode psychotic mania: An 8-week randomised controlled trial. Eur Psychiatry. 2015 Nov;30(8):975–82. doi: http://dx​.doi.org/10​.1016/j.eurpsy.2015.09.009. PMID: 26485297. [PubMed: 26485297]

Houston JP, Tohen M, Degenhardt EK, et al Olanzapine-divalproex combination versus divalproex monotherapy in the treatment of bipolar mixed episodes: a double-blind, placebo-controlled study. [Erratum appears in J Clin Psychiatry. 2011 Aug;72(8):1157], [Erratum appears in J Clin Psychiatry. 2010 Jan;71(1):93]. J Clin Psychiatry. 2009 Nov;70(11):1540–7. doi: http://dx​.doi.org/10​.4088/JCP.08m04895yel. PMID: 19778495. [PubMed: 19778495]

Tohen M, Bowden CL, Smulevich AB, et al Olanzapine plus carbamazepine v. carbamazepine alone in treating manic episodes. Br J Psychiatry. 2008 Feb;192(2):135–43. doi: http://dx​.doi.org/10​.1192/bjp.bp.107.041301. PMID: 18245032. [PubMed: 18245032]

Namjoshi MA, Risser R, Shi L, et al Quality of life assessment in patients with bipolar disorder treated with olanzapine added to lithium or valproic acid. J Affect Disord. 2004;81(3):223–9. PMID: 15337326. [PubMed: 15337326]

Baker RW, Brown E, Akiskal HS, et al Efficacy of olanzapine combined with valproate or lithium in the treatment of dysphoric mania. Br J Psychiatry. 2004 Dec;185:472–8. PMID: 15572737. [PubMed: 15572737]

Moreno RA, Hanna MM, Tavares SM, et al A double-blind comparison of the effect of the antipsychotics haloperidol and olanzapine on sleep in mania. Braz J Med Biol Res. 2007 Mar;40(3):357–66. PMID: 17334533. [PubMed: 17334533]

Tohen M, Sutton VK, Calabrese JR, et al Maintenance of response following stabilization of mixed index episodes with olanzapine monotherapy in a randomized, double-blind, placebo-controlled study of bipolar 1 disorder. J Affect Disord. 2009 Jul;116(1–2):43–50. doi: http://dx​.doi.org/10​.1016/j.jad.2008.11.003. PMID: 19054570. [PubMed: 19054570]

Vieta E, Calabrese JR, Hennen J, et al Comparison of rapid-cycling and non-rapid-cycling bipolar I manic patients during treatment with olanzapine: analysis of pooled data. J Clin Psychiatry. 2004 Oct;65(10):1420–8. PMID: 15491248. [PubMed: 15491248]

Baker RW, Tohen M, Fawcett J, et al Acute dysphoric mania: treatment response to olanzapine versus placebo. J Clin Psychopharmacol. 2003 Apr;23(2):132–7. PMID: 12640214. [PubMed: 12640214]

Baker RW, Milton DR, Stauffer VL, et al Placebo-controlled trials do not find association of olanzapine with exacerbation of bipolar mania. J Affect Disord. 2003 Jan;73(1–2):147–53. PMID: 12507747. [PubMed: 12507747]

Baldessarini RJ, Hennen J, Wilson M, et al Olanzapine versus placebo in acute mania: treatment responses in subgroups. J Clin Psychopharmacol. 2003 Aug;23(4):370–6. PMID: 12920413. [PubMed: 12920413]

Chengappa KN, Baker RW, Shao L, et al Rates of response, euthymia and remission in two placebo-controlled olanzapine trials for bipolar mania. Bipolar Disord. 2003 Feb;5(1):1–5. PMID: 12656931. [PubMed: 12656931]

Tohen M, Sanger TM, McElroy SL, et al Olanzapine versus placebo in the treatment of acute mania. The Am J Psychiatry. 1999 1999;156(5):702–9. PMID: 10327902. [PubMed: 10327902]

Ketter TA, Houston JP, Adams DH, et al Differential efficacy of olanzapine and lithium in preventing manic or mixed recurrence in patients with bipolar I disorder based on number of previous manic or mixed episodes. J Clin Psychiatry. 2006 Jan;67(1):95–101. PMID: 16426094. [PubMed: 16426094]

Tohen M, Ketter TA, Zarate CA, et al Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: a 47-week study. Am J Psychiatry. 2003 Jul;160(7):1263–71. PMID: 12832240. [PubMed: 12832240]

Suppes T, Brown E, Schuh LM, et al Rapid versus non-rapid cycling as a predictor of response to olanzapine and divalproex sodium for bipolar mania and maintenance of remission: post hoc analyses of 47-week data. J Affect Disord. 2005 Dec;89(1–3):69–77. PMID: 16253344. [PubMed: 16253344]

Novick D, Reed C, Haro JM, et al Comparison of olanzapine and risperidone in the EMBLEM Study: translation of randomized controlled trial findings into clinical practice. Int Clin Psychopharmacol. 2010 Sep;25(5):257–63. doi: http://dx​.doi.org/10​.1097/YIC.0b013e32833b8fe4. PMID: 20531011. [PubMed: 20531011]

Sanger TM, Tohen M, Vieta E, et al Olanzapine in the acute treatment of bipolar I disorder with a history of rapid cycling. J Affect Disord. 2003 Jan;73(1–2):155–61. PMID: 12507748. [PubMed: 12507748]

Katagiri H, Takita Y, Tohen M, et al Safety and efficacy of olanzapine monotherapy and olanzapine with a mood stabilizer in 18-week treatment of manic/mixed episodes for Japanese patients with bipolar I disorder. Curr Med Res Opin. 2012 May;28(5):701–13. doi: http://dx​.doi.org/10​.1185/03007995.2012.666961. PMID: 22356118. [PubMed: 22356118]

Brown E, Dunner DL, McElroy SL, et al Olanzapine/fluoxetine combination vs. lamotrigine in the 6-month treatment of bipolar I depression. Int J Neuropsychopharmcol . 2009 Jul;12(6):773–82. doi: http://dx​.doi.org/10​.1017/S1461145708009735. PMID: 19079815. [PubMed: 19079815]

Tohen M, Chengappa KN, Suppes T, et al Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone. Br J Psychiatry. 2004 Apr;184:337–45. PMID: 15056579. [PubMed: 15056579]

Perlis RH, Welge JA, Vornik LA, et al Atypical antipsychotics in the treatment of mania: a meta-analysis of randomized, placebo-controlled trials. J Clin Psychiatry. 2006 Apr;67(4):509–16. PMID: 16669715. [PubMed: 16669715]

Li H, Ma C, Wang G, et al Response and remission rates in Chinese patients with bipolar mania treated for 4 weeks with either quetiapine or lithium: a randomized and double-blind study. Curr Med Res Opin. 2008 Jan;24(1):1–10. PMID: 18028587. [PubMed: 18028587]

Yatham LN, Vieta E, Young AH, et al A double blind, randomized, placebo-controlled trial of quetiapine as an add-on therapy to lithium or divalproex for the treatment of bipolar mania. Int Clin Psychopharmacol. 2007 Jul;22(4):212–20. PMID: 17519644. [PubMed: 17519644]

Yatham LN, Paulsson B, Mullen J, et al Quetiapine versus placebo in combination with lithium or divalproex for the treatment of bipolar mania. [Erratum appears in J Clin Psychopharmacol. 2005 Apr;25(2):201], [Erratum appears in J Clin Psychopharmacol. 2005 Feb;25(1):103]. J Clin Psychopharmacol. 2004 Dec;24(6):599–606. PMID: 15538120. [PubMed: 15538120]

Suppes T, Ketter TA, Gwizdowski IS, et al First controlled treatment trial of bipolar II hypomania with mixed symptoms: quetiapine versus placebo. J Affect Disord. 2013 Aug 15;150(1):37–43. doi: http://dx​.doi.org/10​.1016/j.jad.2013.02.031. PMID: 23521871. [PubMed: 23521871]

Nejtek VA, Avila M, Chen LA, et al Do atypical antipsychotics effectively treat co-occurring bipolar disorder and stimulant dependence? A randomized, double-blind trial. J Clin Psychiatry. 2008 Aug;69(8):1257–66. PMID: 18681757. [PubMed: 18681757]

Vieta E, Suppes T, Ekholm B, et al Long-term efficacy of quetiapine in combination with lithium or divalproex on mixed symptoms in bipolar I disorder. J Affect Disord. 2012 Dec 15;142(1–3):36–44. doi: http://dx​.doi.org/10​.1016/j.jad.2012.04.014. PMID: 23062763. [PubMed: 23062763]

Segal J, Berk M, Brook S. Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial. Clin Neuropharmacol. 1998 May–Jun;21(3):176–80. PMID: 9617509. [PubMed: 9617509]

Yatham LN, Grossman F, Augustyns I, et al Mood stabilisers plus risperidone or placebo in the treatment of acute mania. International, double-blind, randomised controlled trial. [Erratum appears in Br J Psychiatry. 2003 Apr;182:369]. Br J Psychiatry. 2003 Feb;182:141–7. PMID: 12562742. [PubMed: 12562742]

Hirschfeld RM, Keck PE, Jr., Kramer M, et al Rapid antimanic effect of risperidone monotherapy: a 3-week multicenter, double-blind, placebo-controlled trial. Am J Psychiatry. 2004 Jun;161(6):1057–65. PMID: 15169694. [PubMed: 15169694]

Quiroz JA, Yatham LN, Palumbo JM, et al Risperidone long-acting injectable monotherapy in the maintenance treatment of bipolar I disorder. Biol Psychiatry. 2010 Jul 15;68(2):156–62. doi: http://dx​.doi.org/10​.1016/j.biopsych.2010.01.015. PMID: 20227682. [PubMed: 20227682]

Sachs GS, Vanderburg DG, Edman S, et al Adjunctive oral ziprasidone in patients with acute mania treated with lithium or divalproex, part 1: results of a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2012 Nov;73(11):1412–9. doi: http://dx​.doi.org/10.4088/JCP.11m07388. PMID: 23218157. [PubMed: 23218157]

Vieta E, Ramey T, Keller D, et al Ziprasidone in the treatment of acute mania: a 12-week, placebo-controlled, haloperidol-referenced study. J Psychopharmacol. 2010 Apr;24(4):547–58. doi: http://dx​.doi.org/10​.1177/0269881108099418. PMID: 19074536. [PubMed: 19074536]

Stahl S, Lombardo I, Loebel A, et al Efficacy of ziprasidone in dysphoric mania: pooled analysis of two double-blind studies. J Affect Disord. 2010 Apr;122(1–2):39–45. doi: http://dx​.doi.org/10​.1016/j.jad.2009.06.023. PMID: 19616304. [PubMed: 19616304]

Kushner SF, Khan A, Lane R, et al Topiramate monotherapy in the management of acute mania: results of four double-blind placebo-controlled trials. Bipolar Disord. 2006 Feb;8(1):15–27. PMID: 16411977. [PubMed: 16411977]

Weisler RH, Hirschfeld R, Cutler AJ, et al Extended-release carbamazepine capsules as monotherapy in bipolar disorder : pooled results from two randomised, double-blind, placebo-controlled trials. CNS Drugs. 2006;20(3):219–31. PMID: 16529527. [PubMed: 16529527]

Vasudev K, Goswami U, Kohli K. Carbamazepine and valproate monotherapy: feasibility, relative safety and efficacy, and therapeutic drug monitoring in manic disorder. Psychopharmacology. 2000 May;150(1):15–23. PMID: 10867972. [PubMed: 10867972]

Small JG, Klapper MH, Milstein V, et al Carbamazepine compared with lithium in the treatment of mania. Arch Gen Psychiatry. 1991 Oct;48(10):915–21. PMID: 1929761. [PubMed: 1929761]

Lerer B, Moore N, Meyendorff E, et al Carbamazepine versus lithium in mania: a double-blind study. J Clin Psychiatry. 1987 Mar;48(3):89–93. PMID: 3546274. [PubMed: 3546274]

Weisler RH, Kalali AH, Cutler AJ, et al Efficacy and safety of once- versus twice-daily carbamazepine extended-release capsules for the treatment of manic symptoms in patients with bipolar I disorder. Psychiatry. 2008;5(3):35–48. PMID: 22778707. [PMC free article: PMC3392099] [PubMed: 22778707]

Weisler RH, Kalali AH, Ketter TA, et al A multicenter, randomized, double-blind, placebo-controlled trial of extended-release carbamazepine capsules as monotherapy for bipolar disorder patients with manic or mixed episodes. J Clin Psychiatry. 2004 Apr;65(4):478–84. PMID: 15119909. [PubMed: 15119909]

El-Mallakh RS, Salem MR, Chopra AS, et al Adverse event load in bipolar participants receiving either carbamazepine immediate-release or extended-release capsules: a blinded, randomized study. Int Clin Psychopharmacol. 2009 May;24(3):145–9. doi: http://dx​.doi.org/10​.1097/YIC.0b013e328329b199. PMID: 19367153. [PubMed: 19367153]

Bowden CL, Swann AC, Calabrese JR, et al A randomized, placebo-controlled, multicenter study of divalproex sodium extended release in the treatment of acute mania. J Clin Psychiatry. 2006 Oct;67(10):1501–10. PMID: 17107240. [PubMed: 17107240]

Hirschfeld RM, Bowden CL, Vigna NV, et al A randomized, placebo-controlled, multicenter study of divalproex sodium extended-release in the acute treatment of mania. J Clin Psychiatry. 2010 Apr;71(4):426–32. doi: http://dx​.doi.org/10​.4088/JCP.08m04960yel. PMID: 20361904. [PubMed: 20361904]

McElroy SL, Martens BE, Creech RS, et al Randomized, double-blind, placebo-controlled study of divalproex extended release loading monotherapy in ambulatory bipolar spectrum disorder patients with moderate-to-severe hypomania or mild mania. J Clin Psychiatry. 2010 May;71(5):557–65. doi: http://dx​.doi.org/10​.4088/JCP.08m04854yel. PMID: 20361901. [PubMed: 20361901]

Wang Z, Gao K, Kemp DE, et al Lamotrigine adjunctive therapy to lithium and divalproex in depressed patients with rapid cycling bipolar disorder and a recent substance use disorder: a 12-week, double-blind, placebo-controlled pilot study. Psychopharmacol Bull. 2010;43(4):5–21. PMID: 21240149. [PMC free article: PMC3442254] [PubMed: 21240149]

Bowden CL, Singh V, Weisler R, et al Lamotrigine vs. lamotrigine plus divalproex in randomized, placebo-controlled maintenance treatment for bipolar depression. Acta Psychiatr Scand. 2012 Nov;126(5):342–50. doi: http://dx​.doi.org/10​.1111/j.1600-0447.2012.01890.x. PMID: 22708645. [PubMed: 22708645]

Kemp DE, Gao K, Ganocy SJ, et al A 6-month, double-blind, maintenance trial of lithium monotherapy versus the combination of lithium and divalproex for rapid-cycling bipolar disorder and Co-occurring substance abuse or dependence. J Clin Psychiatry. 2009 Jan;70(1):113–21. PMID: 19192457. [PMC free article: PMC3587136] [PubMed: 19192457]

Calabrese JR, Shelton MD, Rapport DJ, et al A 20-month, double-blind, maintenance trial of lithium versus divalproex in rapid-cycling bipolar disorder. Am J Psychiatry. 2005 Nov;162(11):2152–61. PMID: 16263857. [PubMed: 16263857]

Bowden CL, Brugger AM, Swann AC, et al Efficacy of divalproex vs lithium and placebo in the treatment of mania. The Depakote Mania Study Group. [Erratum appears in JAMA 1994 Jun 15;271(23):1830]. JAMA. 1994 Mar 23–30;271(12):918–24. PMID: 8120960. [PubMed: 8120960]

Oquendo MA, Galfalvy HC, Currier D, et al Treatment of suicide attempters with bipolar disorder: a randomized clinical trial comparing lithium and valproate in the prevention of suicidal behavior. [Erratum appears in Am J Psychiatry. 2012 Feb;169(2):223]. Am J Psychiatry. 2011 Oct;168(10):1050–6. doi: http://dx​.doi.org/10​.1176/appi.ajp.2011.11010163. PMID: 21768611. [PMC free article: PMC3767999] [PubMed: 21768611]

Salloum IM, Cornelius JR, Daley DC, et al Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study. Arch Gen Psychiatry. 2005 Jan;62(1):37–45. PMID: 15630071. [PubMed: 15630071]

Ichim L, Berk M, Brook S. Lamotrigine compared with lithium in mania: a double-blind randomized controlled trial. Ann Clin Psychiatry. 2000 Mar;12(1):5–10. PMID: 10798820. [PubMed: 10798820]

Licht RW, Nielsen JN, Gram LF, et al Lamotrigine versus lithium as maintenance treatment in bipolar I disorder: an open, randomized effectiveness study mimicking clinical practice. The 6th trial of the Danish University Antidepressant Group (DUAG-6). Bipolar Disord. 2010 Aug;12(5):483–93. doi: http://dx​.doi.org/10​.1111/j.1399-5618.2010.00836.x. PMID: 20712749. [PubMed: 20712749]

Bowden CL, Calabrese JR, Ketter TA, et al Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder. Am J Psychiatry. 2006 Jul;163(7):1199–201. PMID: 16816224. [PubMed: 16816224]

Calabrese JR, Suppes T, Bowden CL, et al A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. Lamictal 614 Study Group. J Clin Psychiatry. 2000 Nov;61(11):841–50. PMID: 11105737. [PubMed: 11105737]

Goldberg JF, Calabrese JR, Saville BR, et al Mood stabilization and destabilization during acute and continuation phase treatment for bipolar I disorder with lamotrigine or placebo. J Clin Psychiatry. 2009 Sep;70(9):1273–80. doi: http://dx​.doi.org/10.4088/JCP.08m04381. PMID: 19689918. [PubMed: 19689918]

Bowden CL, Mosolov S, Hranov L, et al Efficacy of valproate versus lithium in mania or mixed mania: a randomized, open 12-week trial. Int Clin Psychopharmacol. 2010 Mar;25(2):60–7. doi: http://dx​.doi.org/10​.1097/YIC.0b013e328333ac1b. PMID: 20101186. [PubMed: 20101186]

Amsterdam JD, Luo L, Shults J. Efficacy and mood conversion rate during long-term fluoxetine v. lithium monotherapy in rapid- and non-rapid-cycling bipolar II disorder. Br J Psychiatry. 2013 2013;202(4):301–6. doi: http://dx​.doi.org/10​.1192/bjp.bp.111.104711. PMID: 23099447. [PMC free article: PMC3613721] [PubMed: 23099447]

Ahmad A, Sheikh S, Shah T, et al Endoxifen, a New Treatment Option for Mania: A Double-Blind, Active-Controlled Trial Demonstrates the Antimanic Efficacy of Endoxifen. Clin Transl Sci. 2016 01 Oct;9(5):252–9. doi: http://dx​.doi.org/10.1111/cts.12407. PMID: 27346789 PMID/611114504 Embase. [PMC free article: PMC5350997] [PubMed: 27346789]

Arabzadeh S, Ameli N, Zeinoddini A, et al Celecoxib adjunctive therapy for acute bipolar mania: A randomized, double-blind, placebo-controlled trial. Bipolar Disord. 2015 01 Sep;17(6):606–14. doi: http://dx​.doi.org/10.1111/bdi.12324. PMID: 26291962 (pubmed) 2015329826 (embase). [PubMed: 26291962]

Jahangard L, Soroush S, Haghighi M, et al In a double-blind, randomized and placebo-controlled trial, adjuvant allopurinol improved symptoms of mania in in-patients suffering from bipolar disorder. Eur Neuropsychopharmacol. Jun. 2014 2, 2014(Pagination)doi: http://dx​.doi.org/10​.1016/j.euroneuro.2014.05.013. PMID: 24953766. [PubMed: 24953766]

Weiser M, Burshtein S, Gershon AA, et al Allopurinol for mania: A randomized trial of allopurinol versus placebo as add-on treatment to mood stabilizers and/or antipsychotic agents in manic patients with bipolar disorder. Bipolar Disord. 2014 2014;16(4):441–7. doi: http://dx​.doi.org/10.1111/bdi.12202. PMID: 24712840. [PubMed: 24712840]

Fan A, Berg A, Bresee C, et al Allopurinol augmentation in the outpatient treatment of bipolar mania: a pilot study. Bipolar Disord. 2012 Mar;14(2):206–10. doi: http://dx​.doi.org/10​.1111/j.1399-5618.2012.01001.x. PMID: 22420596. [PubMed: 22420596]

Astaneh AN, Rezaei O. Adjunctive treatment with gabapentin in bipolar patients during acute mania. Int J Psychiatry Med. 2012;43(3):261–71. PMID: 22978083. [PubMed: 22978083]

Yildiz A, Guleryuz S, Ankerst DP, et al Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen. Arch Gen Psychiatry. 2008 Mar;65(3):255–63. doi: http://dx​.doi.org/10​.1001/archgenpsychiatry.2007.43. PMID: 18316672. [PubMed: 18316672]

Chengappa RKN, Schwarzman LK, Hulihan JF, et al Adjunctive topiramate therapy in patients receiving a mood stabilizer for bipolar I disorder: a randomized, placebo-controlled trial. J Clin Psychiatry. 2006 Nov;67(11):1698–706. PMID: 17196048. [PubMed: 17196048]

Machado-Vieira R, Soares JC, Lara DR, et al A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania. J Clin Psychiatry. 2008 Aug;69(8):1237–45. PMID: 18681754. [PMC free article: PMC2727594] [PubMed: 18681754]

Chen J, Lu Z, Zhang M, et al A randomized, 4-week double-blind placebo control study on the efficacy of donepezil augmentation of lithium for treatment of acute mania. Neuropsychiatr Dis Treat. 2013 17, 2013;9:839–45. PMID: 23807849. [PMC free article: PMC3688436] [PubMed: 23807849]

Bahk WM, Shin YC, Woo JM, et al Topiramate and divalproex in combination with risperidone for acute mania: a randomized open-label study. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jan;29(1):115–21. doi: 10.1016/j.pnpbp.2004.10.013. PMID: 15610953. [PubMed: 15610953] [CrossRef]

Berwaerts J, Melkote R, Nuamah I, et al A randomized, placebo- and active-controlled study of paliperidone extended-release as maintenance treatment in patients with bipolar I disorder after an acute manic or mixed episode. J Affect Disord. 2012 May;138(3):247–58. doi: http://dx​.doi.org/10​.1016/j.jad.2012.01.047. PMID: 22377512. [PubMed: 22377512]

Berwaerts J, Xu H, Nuamah I, et al Evaluation of the efficacy and safety of paliperidone extended-release in the treatment of acute mania: a randomized, double-blind, dose-response study. J Affect Disord. 2012 Jan;136(1–2):e51–60. doi: http://dx​.doi.org/10​.1016/j.jad.2010.06.030. PMID: 20624657. [PubMed: 20624657]

Berwaerts J, Lane R, Nuamah IF, et al Paliperidone extended-release as adjunctive therapy to lithium or valproate in the treatment of acute mania: a randomized, placebo-controlled study. J Affect Disord. 2011 Mar;129(1–3):252–60. doi: http://dx​.doi.org/10​.1016/j.jad.2010.09.011. PMID: 20947174. [PubMed: 20947174]

Vik A, Ravindran A, Shiah IS, et al A double-blind, placebo-controlled study of adjunctive calcitonin nasal spray in acute refractory mania. Bipolar Disord. 2013 2013;15(4):359–64. PMID: 23551803. [PubMed: 23551803]

Grunze H, Kotlik E, Costa R, et al Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence: experience from multicentre, double-blind, randomised phase II clinical studies in patients with bipolar disorder I. J Affect Disord. 2015 Mar 15;174:70–82. doi: http://dx​.doi.org/10​.1016/j.jad.2014.11.013. PMID: 25484179. [PubMed: 25484179]

Amsterdam JD, Garcia-Espana F, Fawcett J, et al Efficacy and safety of fluoxetine in treating bipolar II major depressive episode. J Clin Psychopharmacol. 1998 Dec;18(6):435–40. PMID: 9864074. [PubMed: 9864074]

Amsterdam JD, Shults J. Comparison of short-term venlafaxine versus lithium monotherapy for bipolar II major depressive episode: a randomized open-label study. J Clin Psychopharmacol. 2008 Apr;28(2):171–81. doi: 10.1097/JCP.0b013e318166c4e6. PMID: 18344727. [PubMed: 18344727] [CrossRef]

Nierenberg AA, Sylvia LG, Leon AC, et al Lithium treatment - moderate dose use study (LiTMUS) for bipolar disorder: rationale and design. Clinical Trials. 2009 Dec;6(6):637–48. doi: http://dx​.doi.org/10​.1177/1740774509347399. PMID: 19933719. [PubMed: 19933719]

Kemp DE, Gao K, Fein EB, et al Lamotrigine as add-on treatment to lithium and divalproex: lessons learned from a double-blind, placebo-controlled trial in rapid-cycling bipolar disorder. Bipolar Disord. 2012 Nov;14(7):780–9. doi: http://dx​.doi.org/10.1111/bdi.12013. PMID: 23107222. [PMC free article: PMC3640341] [PubMed: 23107222]

Lee SY, Chen SL, Chang YH, et al Genotype variant associated with add-on memantine in bipolar II disorder. [Erratum appears in Int J Neuropsychopharmacol. 2014 Jun;17(6):979 Note: Lu, Ru-Band [removed]; Hong, Jau-Shyong [added]]. Int J Neuropsychopharmcol . 2014 Feb;17(2):189–97. doi: http://dx​.doi.org/10​.1017/S1461145713000825. PMID: 24103632. [PubMed: 24103632]

Lee S-Y, Chen S-L, Chang Y-H, et al Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder. J Psychiatr Res. 2013 2013;47(10):1343–8. doi: http://dx​.doi.org/10​.1016/j.jpsychires.2013.06.017. PMID: 23870798. [PMC free article: PMC4786167] [PubMed: 23870798]

Sachs GS, Nierenberg AA, Calabrese JR, et al Effectiveness of adjuctive antidepressant treatment for bipolar depression. The N Engl J Med. 2007 2007;356(17):1711–22. doi: http://dx​.doi.org/10.1056/NEJMoa064135. PMID: 17392295. [PubMed: 17392295]

Altshuler LL, Sugar CA, McElroy SL, et al Switch rates during acute treatment for Bipolar II depression with Lithium, Sertraline, or the two combined: A randomized double-blind comparison. Am J Psychiatry. 2017 March;174(3):266–76. doi: http://dx​.doi.org/10​.1176/appi.ajp.2016.15040558. PMID: 28135846 PMID/614689619 Embase. [PubMed: 28135846]

Amsterdam JD, Lorenzo-Luaces L, Soeller I, et al Short-term venlafaxine v. lithium monotherapy for bipolar type II major depressive episodes: Effectiveness and mood conversion rate. Br J Psychiatry. 2016 April;208(4):359–65. doi: http://dx​.doi.org/10​.1192/bjp.bp.115.169375. PMID: 26892848 PMID/609914520 Embase. [PMC free article: PMC4816972] [PubMed: 26892848]

Lorenzo-Luaces L, Amsterdam JD, Soeller I, et al Rapid versus non-rapid cycling bipolar II depression: Response to venlafaxine and lithium and hypomanic risk. Acta Psychiatr Scand. 2016 01 Jun;133(6):459–69. doi: http://dx​.doi.org/10.1111/acps.12557. PMID: 26803764 PMID/608565179 Embase. [PMC free article: PMC4879786] [PubMed: 26803764]

Amsterdam JD, Wang CH, Shwarz M, et al Venlafaxine versus lithium monotherapy of rapid and non-rapid cycling patients with bipolar II major depressive episode: a randomized, parallel group, open-label trial. J Affect Disord. 2009 Jan;112(1–3):219–30. doi: http://dx​.doi.org/10​.1016/j.jad.2008.03.029. PMID: 18486235. [PubMed: 18486235]

Ghaemi SN, Ostacher MM, El-Mallakh RS, et al Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety. J Clin Psychiatry. 2010 Apr;71(4):372–80. doi: http://dx​.doi.org/10​.4088/JCP.08m04909gre. PMID: 20409444. [PubMed: 20409444]

Nierenberg AA, Friedman ES, Bowden CL, et al Lithium treatment moderate-dose use study (LiTMUS) for bipolar disorder: a randomized comparative effectiveness trial of optimized personalized treatment with and without lithium. Am J Psychiatry. 2013 Jan 1;170(1):102–10. doi: http://dx​.doi.org/10​.1176/appi.ajp.2012.12060751. PMID: 23288387. [PubMed: 23288387]

Nierenberg AA, McElroy S, Ketter TA, et al Bipolar CHOICE (Clinical Health Outcomes Initiative in Comparative Effectiveness): A pragmatic six month trial of lithium vs. quetiapine for bipolar disorder. Bipolar Disord. 2015 June;17:25–6. doi: http://dx​.doi.org/10.1111/bdi.12306_15.

Nierenberg AA, Sylvia LG, Leon AC, et al Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder (Bipolar CHOICE): a pragmatic trial of complex treatment for a complex disorder. Clinical Trials. 2014 Feb;11(1):114–27. doi: http://dx​.doi.org/10​.1177/1740774513512184. PMID: 24346608. [PMC free article: PMC4495881] [PubMed: 24346608]

Bowden CL, Karayal ON, Schwartz JH, et al Characterizing relapse prevention in bipolar disorder with adjunctive ziprasidone: clinical and methodological implications. J Affect Disord. 2013 Jan 10;144(1–2):171–5. doi: http://dx​.doi.org/10​.1016/j.jad.2012.04.024. PMID: 22999893. [PubMed: 22999893]

Balance investigators, Geddes JR, Goodwin GM, et al Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial. Lancet. 2010 Jan 30;375(9712):385–95. doi: http://dx​.doi.org/10​.1016/S0140-6736(09)61828-6. PMID: 20092882. [PubMed: 20092882]

Amsterdam JD, Lorenzo-Luaces L, Soeller I, et al Safety and effectiveness of continuation antidepressant versus mood stabilizer monotherapy for relapse-prevention of bipolar II depression: A randomized, double-blind, parallel-group, prospective study. J Affect Disord. 2015 06 Jul;185:31–7. doi: http://dx​.doi.org/10​.1016/j.jad.2015.05.070. PMID: 26143402 (pubmed) 2015175772 (embase). [PMC free article: PMC4540653] [PubMed: 26143402]

Amsterdam JD, Shults J. Efficacy and safety of long-term fluoxetine versus lithium monotherapy of bipolar II disorder: a randomized, double-blind, placebo-substitution study. Am J Psychiatry. 2010 Jul;167(7):792–800. doi: http://dx​.doi.org/10​.1176/appi.ajp.2009.09020284. PMID: 20360317. [PMC free article: PMC2896440] [PubMed: 20360317]

Bobo WV, Epstein RA, Lynch A, et al A randomized open comparison of long-acting injectable risperidone and treatment as usual for prevention of relapse, rehospitalization, and urgent care referral in community-treated patients with rapid cycling bipolar disorder. Clin Neuropharmacol. 2011 Nov–Dec;34(6):224–33. doi: http://dx​.doi.org/10​.1097/WNF.0b013e318237709a. PMID: 22104634. [PMC free article: PMC3951021] [PubMed: 22104634]

Bowden CL, Calabrese JR, McElroy SL, et al A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group. Arch Gen Psychiatry. 2000 May;57(5):481–9. PMID: 10807488. [PubMed: 10807488]

Bowden CL, Calabrese JR, Sachs G, et al A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. [Erratum appears in Arch Gen Psychiatry. 2004 Jul;61(7):680]. Arch Gen Psychiatry. 2003 Apr;60(4):392–400. PMID: 12695317. [PubMed: 12695317]

Bowden CL, Vieta E, Ice KS, et al Ziprasidone plus a mood stabilizer in subjects with bipolar I disorder: a 6-month, randomized, placebo-controlled, double-blind trial. J Clin Psychiatry. 2010 Feb;71(2):130–7. doi: http://dx​.doi.org/10​.4088/JCP.09m05482yel. PMID: 20122373. [PubMed: 20122373]

Calabrese JR, Bowden CL, Sachs G, et al A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry. 2003 Sep;64(9):1013–24. PMID: 14628976. [PubMed: 14628976]

Greil W, Kleindienst N. Lithium versus carbamazepine in the maintenance treatment of bipolar II disorder and bipolar disorder not otherwise specified. Int Clin Psychopharmacol. 1999 Sep;14(5):283–5. PMID: 10529071. [PubMed: 10529071]

Greil W, Kleindienst N. The comparative prophylactic efficacy of lithium and carbamazepine in patients with bipolar I disorder. Int Clin Psychopharmacol. 1999 Sep;14(5):277–81. PMID: 10529070. [PubMed: 10529070]

Greil W, Kleindienst N, Erazo N, et al Differential response to lithium and carbamazepine in the prophylaxis of bipolar disorder. J Clin Psychopharmacol. 1998 Dec;18(6):455–60. PMID: 9864077. [PubMed: 9864077]

Greil W, Ludwig-Mayerhofer W, Erazo N, et al Lithium versus carbamazepine in the maintenance treatment of bipolar disorders-a randomised study. J Affect Disord. 1997 Apr;43(2):151–61. PMID: 9165384. [PubMed: 9165384]

Gyulai L, Bowden CL, McElroy SL, et al Maintenance efficacy of divalproex in the prevention of bipolar depression. Neuropsychopharmacology. 2003 Jul;28(7):1374–82. PMID: 12784116. [PubMed: 12784116]

Hartong EG, Moleman P, Hoogduin CA, et al Prophylactic efficacy of lithium versus carbamazepine in treatment-naive bipolar patients. J Clin Psychiatry. 2003 Feb;64(2):144–51. PMID: 12633122. [PubMed: 12633122]

Macfadden W, Alphs L, Haskins JT, et al A randomized, double-blind, placebo-controlled study of maintenance treatment with adjunctive risperidone long-acting therapy in patients with bipolar I disorder who relapse frequently. Bipolar Disord. 2009 Dec;11(8):827–39. doi: http://dx​.doi.org/10​.1111/j.1399-5618.2009.00761.x. PMID: 19922552. [PubMed: 19922552]

Marcus R, Khan A, Rollin L, et al Efficacy of aripiprazole adjunctive to lithium or valproate in the long-term treatment of patients with bipolar I disorder with an inadequate response to lithium or valproate monotherapy: a multicenter, double-blind, randomized study. Bipolar Disord. 2011 Mar;13(2):133–44. doi: http://dx​.doi.org/10​.1111/j.1399-5618.2011.00898.x. PMID: 21443567. [PubMed: 21443567]

Newport DJ, Stowe ZN, Viguera AC, et al Lamotrigine in bipolar disorder: efficacy during pregnancy. Bipolar Disord. 2008 May;10(3):432–6. doi: http://dx​.doi.org/10​.1111/j.1399-5618.2007.00565.x. PMID: 18402631. [PubMed: 18402631]

Nierenberg AA, McElroy SL, Friedman ES, et al Bipolar CHOICE (Clinical Health Outcomes Initiative in Comparative Effectiveness): a pragmatic 6-month trial of lithium versus quetiapine for bipolar disorder. J Clin Psychiatry. 2016 Jan;77(1):90–9. doi: http://dx​.doi.org/10.4088/JCP.14m09349. PMID: 26845264. [PubMed: 26845264]

Prien RF, Point P, Caffey EM, et al Prophylactic efficacy of lithium carbonate in manic-depressive illness: Report of the veterans administration and national institute of mental health collaborative study group. Arch Gen Psychiatry. 1973;28(3):337–41. doi: 10.1001/archpsyc.1973.01750330035006. PMID: 4569674. [PubMed: 4569674] [CrossRef]

Suppes T, Vieta E, Liu S, et al Maintenance treatment for patients with bipolar I disorder: results from a north american study of quetiapine in combination with lithium or divalproex (trial 127). Am J Psychiatry. 2009 Apr;166(4):476–88. doi: http://dx​.doi.org/10​.1176/appi.ajp.2008.08020189. PMID: 19289454. [PubMed: 19289454]

Tohen M, Calabrese JR, Sachs GS, et al Randomized, placebo-controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder responding to acute treatment with olanzapine. Am J Psychiatry. 2006 Feb;163(2):247–56. PMID: 16449478. [PubMed: 16449478]

Tohen M, Greil W, Calabrese JR, et al Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial. Am J Psychiatry. 2005 Jul;162(7):1281–90. PMID: 15994710. [PubMed: 15994710]

Vieta E, Cruz N, Garcia-Campayo J, et al A double-blind, randomized, placebo-controlled prophylaxis trial of oxcarbazepine as adjunctive treatment to lithium in the long-term treatment of bipolar I and II disorder. Int J Neuropsychopharmcol. 2008 Jun;11(4):445–52. doi: http://dx​.doi.org/10​.1017/S1461145708008596. PMID: 18346292. [PubMed: 18346292]

Vieta E, Manuel Goikolea J, Martinez-Aran A, et al A double-blind, randomized, placebo-controlled, prophylaxis study of adjunctive gabapentin for bipolar disorder. J Clin Psychiatry. 2006 Mar;67(3):473–7. PMID: 16649836. [PubMed: 16649836]

Vieta E, Montgomery S, Sulaiman AH, et al A randomized, double-blind, placebo-controlled trial to assess prevention of mood episodes with risperidone long-acting injectable in patients with bipolar I disorder. Eur Neuropsychopharmacol. 2012 Nov;22(11):825–35. doi: http://dx​.doi.org/10​.1016/j.euroneuro.2012.03.004. PMID: 22503488. [PubMed: 22503488]

Vieta E, Owen R, Baudelet C, et al Assessment of safety, tolerability and effectiveness of adjunctive aripiprazole to lithium/valproate in bipolar mania: a 46-week, open-label extension following a 6-week double-blind study. Curr Med Res Opin. 2010 Jun;26(6):1485–96. doi: http://dx​.doi.org/10​.1185/03007991003779380. PMID: 20429835. [PubMed: 20429835]

Vieta E, Suppes T, Eggens I, et al Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord. 2008 Aug;109(3):251–63. doi: http://dx​.doi.org/10​.1016/j.jad.2008.06.001. PMID: 18579216. [PubMed: 18579216]

Weisler RH, Nolen WA, Neijber A, et al Continuation of quetiapine versus switching to placebo or lithium for maintenance treatment of bipolar I disorder (Trial 144: a randomized controlled study). J Clin Psychiatry. 2011 Nov;72(11):1452–64. doi: http://dx​.doi.org/10.4088/JCP.11m06878. PMID: 22054050. [PubMed: 22054050]

Woo YS, Bahk WM, Chung MY, et al Aripiprazole plus divalproex for recently manic or mixed patients with bipolar I disorder: a 6-month, randomized, placebo-controlled, double-blind maintenance trial. Hum Psychopharmacol. 2011 Dec;26(8):543–53. doi: http://dx​.doi.org/10.1002/hup.1240. PMID: 22134973. [PubMed: 22134973]

Zarate CA, Jr., Tohen M. Double-blind comparison of the continued use of antipsychotic treatment versus its discontinuation in remitted manic patients. Am J Psychiatry. 2004 Jan;161(1):169–71. PMID: 14702269. [PubMed: 14702269]

Kleindienst N, Greil W. Differential efficacy of lithium and carbamazepine in the prophylaxis of bipolar disorder: results of the MAP study. Neuropsychobiology. 2000;42 Suppl 1:2–10. PMID: 11093063. [PubMed: 11093063]

Calabrese JR, Sanchez R, Jin N, et al Efficacy and safety of aripiprazole once-monthly in the maintenance treatment of bipolar i disorder: A double-blind, placebo-controlled, 52-week randomized withdrawal study. J Clin Psychiatry. 2017 March;78(3):324–31. doi: http://dx​.doi.org/10.4088/JCP.16m11201. PMID: 28146613 PMID/615221995 Embase. [PubMed: 28146613]

Carlson BX, Ketter TA, Sun W, et al Aripiprazole in combination with lamotrigine for the long-term treatment of patients with bipolar I disorder (manic or mixed): a randomized, multicenter, double-blind study (CN138-392). Bipolar Disord. 2012 Feb;14(1):41–53. doi: http://dx​.doi.org/10​.1111/j.1399-5618.2011.00974.x. PMID: 22329471. [PubMed: 22329471]

Masand PS, Eudicone J, Pikalov A, et al Criteria for defining symptomatic and sustained remission in bipolar I disorder: a post-hoc analysis of a 26-week aripiprazole study (study CN138-010). Psychopharmacol Bull. 2008;41(2):12–23. PMID: 18668014. [PubMed: 18668014]

Keck PE, Jr., Calabrese JR, McIntyre RS, et al Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placebo. J Clin Psychiatry. 2007 Oct;68(10):1480–91. PMID: 17960961. [PubMed: 17960961]

El-Mallakh RS, Marcus R, Baudelet C, et al A 40-week double-blind aripiprazole versus lithium follow-up of a 12-week acute phase study (total 52 weeks) in bipolar I disorder. J Affect Disord. 2012 Feb;136(3):258–66. doi: http://dx​.doi.org/10​.1016/j.jad.2011.11.043. PMID: 22209190. [PubMed: 22209190]

Solomon DA, Ristow WR, Keller MB, et al Serum lithium levels and psychosocial function in patients with bipolar I disorder. Am J Psychiatry. 1996 Oct;153(10):1301–7. PMID: 8831438. [PubMed: 8831438]

Barnes CW, Hadzi-Pavlovic D, Wilhelm K, et al A web-based preventive intervention program for bipolar disorder: outcome of a 12-months randomized controlled trial. J Affect Disord. 2015 Mar 15;174:485–92. doi: http://dx​.doi.org/10​.1016/j.jad.2014.11.038. PMID: 25554993. [PubMed: 25554993]

Colom F, Vieta E, Martinez-Aran A, et al A randomized trial on the efficacy of group psychoeducation in the prophylaxis of recurrences in bipolar patients whose disease is in remission. Arch Gen Psychiatry. 2003 Apr;60(4):402–7. PMID: 12695318. [PubMed: 12695318]

Colom F, Vieta E, Reinares M, et al Psychoeducation efficacy in bipolar disorders: beyond compliance enhancement. J Clin Psychiatry. 2003 Sep;64(9):1101–5. PMID: 14628987. [PubMed: 14628987]

Colom F, Vieta E, Sanchez-Moreno J, et al Group psychoeducation for stabilised bipolar disorders: 5-year outcome of a randomised clinical trial. [Erratum appears in Br J Psychiatry. 2009 Jun;194(6):571]. Br J Psychiatry. 2009 Mar;194(3):260–5. doi: http://dx​.doi.org/10​.1192/bjp.bp.107.040485. PMID: 19252157. [PubMed: 19252157]

de Barros Pellegrinelli K, de OCLF, Silval KI, et al Efficacy of psychoeducation on symptomatic and functional recovery in bipolar disorder. Acta Psychiatr Scand. 2013 Feb;127(2):153–8. doi: http://dx​.doi.org/10.1111/acps.12007. PMID: 22943487. [PubMed: 22943487]

Depp CA, Ceglowski J, Wang VC, et al Augmenting psychoeducation with a mobile intervention for bipolar disorder: a randomized controlled trial. J Affect Disord. 2015 Mar 15;174:23–30. doi: http://dx​.doi.org/10​.1016/j.jad.2014.10.053. PMID: 25479050. [PMC free article: PMC4339469] [PubMed: 25479050]

Javadpour A, Hedayati A, Dehbozorgi GR, et al The impact of a simple individual psycho-education program on quality of life, rate of relapse and medication adherence in bipolar disorder patients. Asian J Psychiatr. 2013 Jun;6(3):208–13. doi: http://dx​.doi.org/10​.1016/j.ajp.2012.12.005. PMID: 23642977. [PubMed: 23642977]

Perry A, Tarrier N, Morriss R, et al Randomised controlled trial of efficacy of teaching patients with bipolar disorder to identify early symptoms of relapse and obtain treatment. BMJ. 1999 Jan 16;318(7177):149–53. PMID: 9888904. [PMC free article: PMC27688] [PubMed: 9888904]

Sajatovic M, Davies MA, Ganocy SJ, et al A comparison of the life goals program and treatment as usual for individuals with bipolar disorder. Psychiatr Serv. 2009 Sep;60(9):1182–9. doi: http://dx​.doi.org/10​.1176/appi.ps.60.9.1182. PMID: 19723732. [PMC free article: PMC3148581] [PubMed: 19723732]

Smith DJ, Griffiths E, Poole R, et al Beating Bipolar: exploratory trial of a novel Internet-based psychoeducational treatment for bipolar disorder. Bipolar Disord. 2011 Aug–Sep;13(5–6):571–7. doi: http://dx​.doi.org/10​.1111/j.1399-5618.2011.00949.x. PMID: 22017225. [PubMed: 22017225]

Weiss RD, Griffin ML, Greenfield SF, et al Group therapy for patients with bipolar disorder and substance dependence: results of a pilot study. J Clin Psychiatry. 2000 May;61(5):361–7. PMID: 10847311. [PubMed: 10847311]

Gumus F, Buzlu S, Cakir S. Effectiveness of individual psychoeducation on recurrence in bipolar disorder; a controlled study. Archives of psychiatric nursing. 2015 01 Jun;29(3):174–9. doi: http://dx​.doi.org/10​.1016/j.apnu.2015.01.005. PMID: 26001717. [PubMed: 26001717]

Bilderbeck AC, Atkinson LZ, McMahon HC, et al Psychoeducation and online mood tracking for patients with bipolar disorder: A randomised controlled trial. J Affect Disord. 2016 15 Nov;205:245–51. doi: http://dx​.doi.org/10​.1016/j.jad.2016.06.064. PMID: 27454410 PMID/612460558 Embase. [PubMed: 27454410]

Kallestad H, Wullum E, Scott J, et al The long-term outcomes of an effectiveness trial of group versus individual psychoeducation for bipolar disorders. J Affect Disord. 2016;202:32–8. doi: http://dx​.doi.org/10​.1016/j.jad.2016.05.043. PMID: 27253214 PMID/611342382 Embase. [PubMed: 27253214]

Camacho EM, Ntais D, Jones S, et al Cost-effectiveness of structured group psychoeducation versus unstructured group support for bipolar disorder: Results from a multi-centre pragmatic randomised controlled trial. J Affect Disord. 2017 15 Mar;211:27–36. doi: http://dx​.doi.org/10​.1016/j.jad.2017.01.005. PMID: 614007566. [PubMed: 28086146]

Morriss R, Lobban F, Riste L, et al Clinical effectiveness and acceptability of structured group psychoeducation versus optimised unstructured peer support for patients with remitted bipolar disorder (PARADES): a pragmatic, multicentre, observer-blind, randomised controlled superiority trial. The Lancet Psychiatry. 2016 01 Nov;3(11):1029–38. doi: http://dx​.doi.org/10​.1016/S2215-0366%2816%2930302-9. PMID: 27688021. [PubMed: 27688021]

Weiss RD, Griffin ML, Kolodziej ME, et al A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence. Am J Psychiatry. 2007 Jan;164(1):100–7. PMID: 17202550. [PubMed: 17202550]

Weiss RD, Griffin ML, Jaffee WB, et al A “community-friendly” version of integrated group therapy for patients with bipolar disorder and substance dependence: a randomized controlled trial. Drug Alcohol Depend. 2009 Oct 1;104(3):212–9. doi: http://dx​.doi.org/10​.1016/j.drugalcdep.2009.04.018. PMID: 19573999. [PMC free article: PMC2735139] [PubMed: 19573999]

Scott J, Paykel E, Morriss R, et al Cognitive-behavioural therapy for severe and recurrent bipolar disorders: randomised controlled trial. Br J Psychiatry. 2006 Apr;188:313–20. PMID: 16582056. [PubMed: 16582056]

Parikh SV, Zaretsky A, Beaulieu S, et al A randomized controlled trial of psychoeducation or cognitive-behavioral therapy in bipolar disorder: a Canadian Network for Mood and Anxiety treatments (CANMAT) study [CME]. J Clin Psychiatry. 2012 Jun;73(6):803–10. doi: http://dx​.doi.org/10.4088/JCP.11m07343. PMID: 22795205. [PubMed: 22795205]

Meyer TD, Hautzinger M. Cognitive behaviour therapy and supportive therapy for bipolar disorders: relapse rates for treatment period and 2-year follow-up. Psychol Med. 2012 Jul;42(7):1429–39. doi: http://dx​.doi.org/10​.1017/S0033291711002522. PMID: 22099722. [PubMed: 22099722]

Lam DH, Watkins ER, Hayward P, et al A randomized controlled study of cognitive therapy for relapse prevention for bipolar affective disorder: outcome of the first year. Arch Gen Psychiatry. 2003 Feb;60(2):145–52. PMID: 12578431. [PubMed: 12578431]

Lam DH, Hayward P, Watkins ER, et al Relapse prevention in patients with bipolar disorder: cognitive therapy outcome after 2 years. Am J Psychiatry. 2005 Feb;162(2):324–9. PMID: 15677598. [PubMed: 15677598]

Jones SH, Smith G, Mulligan LD, et al Recovery-focused cognitive-behavioural therapy for recent-onset bipolar disorder: randomised controlled pilot trial. [Erratum appears in Br J Psychiatry. 2015 Feb;206(2):169]. Br J Psychiatry. 2015 Jan;206(1):58–66. doi: http://dx​.doi.org/10​.1192/bjp.bp.113.141259. PMID: 25213157. [PubMed: 25213157]

Harvey AG, Soehner AM, Kaplan KA, et al Treating insomnia improves mood state, sleep, and functioning in bipolar disorder: a pilot randomized controlled trial. J Consult Clin Psychol. 2015 Jun;83(3):564–77. doi: 10.1037/a0038655. PMID: 25622197. [PMC free article: PMC4446240] [PubMed: 25622197] [CrossRef]

Gomes BC, Abreu LN, Brietzke E, et al A randomized controlled trial of cognitive behavioral group therapy for bipolar disorder. Psychother Psychosom. 2011;80(3):144–50. doi: http://dx​.doi.org/10.1159/000320738. PMID: 21372622. [PubMed: 21372622]

Fava GA, Rafanelli C, Tomba E, et al The sequential combination of cognitive behavioral treatment and well-being therapy in cyclothymic disorder. Psychother Psychosom. 2011;80(3):136–43. doi: http://dx​.doi.org/10.1159/000321575. PMID: 21372621. [PubMed: 21372621]

Castle D, White C, Chamberlain J, et al Group-based psychosocial intervention for bipolar disorder: randomised controlled trial. Br J Psychiatry. 2010 May;196(5):383–8. doi: http://dx​.doi.org/10​.1192/bjp.bp.108.058263. PMID: 20435965. [PubMed: 20435965]

Ball JR, Mitchell PB, Corry JC, et al A randomized controlled trial of cognitive therapy for bipolar disorder: focus on long-term change. J Clin Psychiatry. 2006 Feb;67(2):277–86. PMID: 16566624. [PubMed: 16566624]

Perich T, Manicavasagar V, Mitchell PB, et al A randomized controlled trial of mindfulness-based cognitive therapy for bipolar disorder. Acta Psychiatr Scand. 2013 May;127(5):333–43. doi: http://dx​.doi.org/10.1111/acps.12033. PMID: 23216045. [PubMed: 23216045]

Bauer MS, McBride L, Williford WO, et al Collaborative care for bipolar disorder: Part II. Impact on clinical outcome, function, and costs. Psychiatr Serv. 2006 Jul;57(7):937–45. PMID: 16816277. [PubMed: 16816277]

Kessing LV, Hansen HV, Hvenegaard A, et al Treatment in a specialised out-patient mood disorder clinic v. standard out-patient treatment in the early course of bipolar disorder: randomised clinical trial. Br J Psychiatry. 2013 Mar;202(3):212–9. doi: http://dx​.doi.org/10​.1192/bjp.bp.112.113548. PMID: 23349295. [PubMed: 23349295]

Kilbourne AM, Goodrich DE, Lai Z, et al Life Goals Collaborative Care for patients with bipolar disorder and cardiovascular disease risk. Psychiatr Serv. 2012 Dec;63(12):1234–8. doi: http://dx​.doi.org/10​.1176/appi.ps.201100528. PMID: 23203358. [PMC free article: PMC4132840] [PubMed: 23203358]

Kilbourne AM, Post EP, Nossek A, et al Improving medical and psychiatric outcomes among individuals with bipolar disorder: a randomized controlled trial. Psychiatr Serv. 2008 Jul;59(7):760–8. doi: http://dx​.doi.org/10​.1176/appi.ps.59.7.760. PMID: 18586993. [PubMed: 18586993]

Simon GE, Ludman EJ, Bauer MS, et al Long-term effectiveness and cost of a systematic care program for bipolar disorder. Arch Gen Psychiatry. 2006 May;63(5):500–8. PMID: 16651507. [PubMed: 16651507]

Simon GE, Ludman EJ, Unutzer J, et al Randomized trial of a population-based care program for people with bipolar disorder. Psychol Med. 2005 Jan;35(1):13–24. PMID: 15842025. [PubMed: 15842025]

van der Voort TY, van Meijel B, Goossens PJ, et al Collaborative care for patients with bipolar disorder: randomised controlled trial. Br J Psychiatry. 2015 Mar 19 doi: 10.1192/bjp.bp.114.152520. PMID: 25792695. [PubMed: 25792695] [CrossRef]

van der Voort TY, van Meijel B, Hoogendoorn AW, et al Collaborative care for patients with bipolar disorder: Effects on functioning and quality of life. J Affect Disord. 2015 Mar 11;179(1):14–22. doi: 10.1016/j.jad.2015.03.005. PMID: 25841077. [PubMed: 25841077] [CrossRef]

D’Souza R, Piskulic D, Sundram S. A brief dyadic group based psychoeducation program improves relapse rates in recently remitted bipolar disorder: a pilot randomised controlled trial. J Affect Disord. 2010 Jan;120(1–3):272–6. doi: http://dx​.doi.org/10​.1016/j.jad.2009.03.018. PMID: 19428117. [PubMed: 19428117]

Miklowitz DJ, George EL, Richards JA, et al A randomized study of family-focused psychoeducation and pharmacotherapy in the outpatient management of bipolar disorder. Arch Gen Psychiatry. 2003 Sep;60(9):904–12. PMID: 12963672. [PubMed: 12963672]

Miklowitz DJ, Simoneau TL, George EL, et al Family-focused treatment of bipolar disorder: 1-year effects of a psychoeducational program in conjunction with pharmacotherapy. Biol Psychiatry. 2000 Sep 15;48(6):582–92. PMID: 11018229. [PubMed: 11018229]

Miller IW, Keitner GI, Ryan CE, et al Family treatment for bipolar disorder: family impairment by treatment interactions. J Clin Psychiatry. 2008 May;69(5):732–40. PMID: 18363424. [PMC free article: PMC2862220] [PubMed: 18363424]

Miller IW, Solomon DA, Ryan CE, et al Does adjunctive family therapy enhance recovery from bipolar I mood episodes? J Affect Disord. 2004 Nov 1;82(3):431–6. PMID: 15555694. [PubMed: 15555694]

Rea MM, Tompson MC, Miklowitz DJ, et al Family-focused treatment versus individual treatment for bipolar disorder: results of a randomized clinical trial. J Consult Clin Psychol. 2003 Jun;71(3):482–92. PMID: 12795572. [PubMed: 12795572]

Simoneau TL, Miklowitz DJ, Richards JA, et al Bipolar disorder and family communication: effects of a psychoeducational treatment program. J Abnorm Psychol. 1999 Nov;108(4):588–97. PMID: 10609423. [PubMed: 10609423]

Solomon DA, Keitner GI, Ryan CE, et al Preventing recurrence of bipolar I mood episodes and hospitalizations: family psychotherapy plus pharmacotherapy versus pharmacotherapy alone. Bipolar Disord. 2008 Nov;10(7):798–805. doi: http://dx​.doi.org/10​.1111/j.1399-5618.2008.00624.x. PMID: 19032711. [PubMed: 19032711]

Wenze SJ, Gaudiano BA, Weinstock LM, et al Adjunctive psychosocial intervention following Hospital discharge for Patients with bipolar disorder and comorbid substance use: A pilot randomized controlled trial. Psychiatry Res. 2015 Aug 30;228(3):516–25. doi: 10.1016/j.psychres.2015.06.005. PMID: 26117247. [PMC free article: PMC4532639] [PubMed: 26117247] [CrossRef]

Frank E, Hlastala S, Ritenour A, et al Inducing lifestyle regularity in recovering bipolar disorder patients: results from the maintenance therapies in bipolar disorder protocol. Biol Psychiatry. 1997 Jun 15;41(12):1165–73. PMID: 9171907. [PubMed: 9171907]

Frank E, Kupfer DJ, Thase ME, et al Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder. Arch Gen Psychiatry. 2005 Sep;62(9):996–1004. PMID: 16143731. [PubMed: 16143731]

Frank E, Soreca I, Swartz HA, et al The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder. Am J Psychiatry. 2008 Dec;165(12):1559–65. doi: http://dx​.doi.org/10​.1176/appi.ajp.2008.07121953. PMID: 18829872. [PMC free article: PMC3308335] [PubMed: 18829872]

Frank E, Swartz HA, Mallinger AG, et al Adjunctive psychotherapy for bipolar disorder: effects of changing treatment modality. J Abnorm Psychol. 1999 Nov;108(4):579–87. PMID: 10609422. [PubMed: 10609422]

Inder ML, Crowe MT, Luty SE, et al Randomized, controlled trial of Interpersonal and Social Rhythm Therapy for young people with bipolar disorder. Bipolar Disord. 2015 Mar;17(2):128–38. doi: 10.1111/bdi.12273. PMID: 25346391. [PubMed: 25346391] [CrossRef]

Inder ML, Crowe MT, Luty SE, et al Prospective rates of suicide attempts and nonsuicidal self-injury by young people with bipolar disorder participating in a psychotherapy study. Aust N Z J Psychiatry. 2016 Feb;50(2):167–73. doi: http://dx​.doi.org/10​.1177/0004867415622268. PMID: 26698820. [PubMed: 26698820]

Rucci P, Frank E, Kostelnik B, et al Suicide attempts in patients with bipolar I disorder during acute and maintenance phases of intensive treatment with pharmacotherapy and adjunctive psychotherapy. Am J Psychiatry. 2002 Jul;159(7):1160–4. PMID: 12091194. [PubMed: 12091194]

Gonzalez Isasi A, Echeburua E, Liminana JM, et al Psychoeducation and cognitive-behavioral therapy for patients with refractory bipolar disorder: A 5-year controlled clinical trial. Eur Psychiatry. Dec. 2014 March 2014 doi: http://dx​.doi.org/10​.1016/j.eurpsy.2012.11.002. PMID: 23276524. [PubMed: 23276524]

Isasi AG, Echeburua E, Liminana JM, et al How effective is a psychological intervention program for patients with refractory bipolar disorder? A randomized controlled trial. J Affect Disord. 2010 Oct;126(1–2):80–7. doi: http://dx​.doi.org/10​.1016/j.jad.2010.03.026. PMID: 20444503. [PubMed: 20444503]

Miklowitz DJ, Richards JA, George EL, et al Integrated family and individual therapy for bipolar disorder: results of a treatment development study. J Clin Psychiatry. 2003 Feb;64(2):182–91. PMID: 12633127. [PubMed: 12633127]

Todd NJ, Jones SH, Hart A, et al A web-based self-management intervention for Bipolar Disorder ‘living with bipolar’: a feasibility randomised controlled trial. J Affect Disord. 2014 Dec;169:21–9. doi: 10.1016/j.jad.2014.07.027. PMID: 25129531. [PubMed: 25129531] [CrossRef]

Zaretsky A, Lancee W, Miller C, et al Is cognitive-behavioural therapy more effective than psychoeducation in bipolar disorder? Canadian Journal of Psychiatry - Revue Canadienne de Psychiatrie. 2008 Jul;53(7):441–8. PMID: 18674402. [PubMed: 18674402]

Fagiolini A, Frank E, Axelson DA, et al Enhancing outcomes in patients with bipolar disorder: results from the Bipolar Disorder Center for Pennsylvanians Study. Bipolar Disord. 2009 Jun;11(4):382–90. doi: http://dx​.doi.org/10​.1111/j.1399-5618.2009.00700.x. PMID: 19500091. [PMC free article: PMC3361715] [PubMed: 19500091]

Faurholt-Jepsen M, Frost M, Ritz C, et al Daily electronic self-monitoring in bipolar disorder using smartphones - the MONARCA I trial: a randomized, placebo-controlled, single-blind, parallel group trial. Psychol Med. 2015 Oct;45(13):2691–704. doi: http://dx​.doi.org/10​.1017/S0033291715000410. PMID: 26220802. [PubMed: 26220802]

Miklowitz DJ, Otto MW, Wisniewski SR, et al Psychotherapy, symptom outcomes, and role functioning over one year among patients with bipolar disorder. Psychiatr Serv. 2006 Jul;57(7):959–65. PMID: 16816280. [PubMed: 16816280]

Deckersbach T, Peters AT, Sylvia L, et al Do comorbid anxiety disorders moderate the effects of psychotherapy for bipolar disorder? Results from STEP-BD. Am J Psychiatry. 2014 Feb;171(2):178–86. doi: http://dx​.doi.org/10​.1176/appi.ajp.2013.13020225. PMID: 24077657. [PMC free article: PMC3946300] [PubMed: 24077657]

Miklowitz DJ, Otto MW, Frank E, et al Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial. Am J Psychiatry. 2007 Sep;164(9):1340–7. PMID: 17728418. [PMC free article: PMC3579578] [PubMed: 17728418]

Miklowitz DJ, Otto MW, Frank E, et al Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program. Arch Gen Psychiatry. 2007 Apr;64(4):419–26. PMID: 17404119. [PMC free article: PMC3579612] [PubMed: 17404119]

Fitzgerald PB, Hoy KE, Elliot D, et al A negative double-blind controlled trial of sequential bilateral rTMS in the treatment of bipolar depression. J Affect Disord. 2016 01 Jul;198:158–62. doi: http://dx​.doi.org/10​.1016/j.jad.2016.03.052. PMID: 27016659 PMID/609157504 Embase. [PubMed: 27016659]

Swartz H, Swanson J. Psychotherapy for bipolar disorder in adults: a review of the evidence. Focus (Am Psychiatr Publ). 2014 Summer;12(3):251–66. doi: 10.1176/appi.focus.12.3.251. PMID: 26279641. [PMC free article: PMC4536930] [PubMed: 26279641] [CrossRef]

Greenhouse WJ, Meyer B, Johnson SL. Coping and medication adherence in bipolar disorder. J Affect Disord. 2000 Sep;59(3):237–41. PMID: 10854641. [PubMed: 10854641]

Council NR. The prevention and treatment of missing data in clinical trials: National Academies Press; 2011. [PubMed: 24983040]

Rendell Jennifer M, Gijsman Harm J, Keck Paul K, et al Olanzapine alone or in combination for acute mania. Cochrane Database of Systematic Reviews: John Wiley & Sons, Ltd; 2003. [PMC free article: PMC6984669] [PubMed: 12918000]

Rendell Jennifer M, Gijsman Harm J, Bauer Mark S, et al Risperidone alone or in combination for acute mania. Cochrane Database of Systematic Reviews: John Wiley & Sons, Ltd; 2006. [PMC free article: PMC6984671] [PubMed: 16437472]

Burgess Sally SA, Geddes J, Hawton Keith KE, et al Lithium for maintenance treatment of mood disorders. Cochrane Database of Systematic Reviews: John Wiley & Sons, Ltd; 2001. [PubMed: 11687035]

Rendell Jennifer M, Geddes J. Risperidone in long-term treatment for bipolar disorder. Cochrane Database of Systematic Reviews: John Wiley & Sons, Ltd; 2006. [PubMed: 17054229]

Brown R, Taylor Matthew J, Geddes J. Aripiprazole alone or in combination for acute mania. Cochrane Database of Systematic Reviews: John Wiley & Sons, Ltd; 2013. [PubMed: 24346956]

Cipriani A, Rendell Jennifer M, Geddes J. Olanzapine in long-term treatment for bipolar disorder. Cochrane Database of Systematic Reviews: John Wiley & Sons, Ltd; 2009. [PubMed: 19160237]

Cipriani A, Rendell Jennifer M, Geddes J. Haloperidol alone or in combination for acute mania. Cochrane Database of Systematic Reviews: John Wiley & Sons, Ltd; 2006. [PubMed: 16856043]

Reilly S, Planner C, Gask L, et al Collaborative care approaches for people with severe mental illness. Cochrane Database of Systematic Reviews: John Wiley & Sons, Ltd; 2013. [PubMed: 24190251]

Friedman LM, Furberg C, DeMets DL, et al Fundamentals of clinical trials: Springer; 1998.

Sackett DL, Strauss SE, Richardson WS, et al Evidence-based medicine: how to practice and teach EBM. Edinburgh: Churchill Livingstone; 2000.

Kristman V, Manno M, Cote P. Loss to follow-up in cohort studies: how much is too much? Eur J Epidemiol. 2004;19(8):751–60. PMID: 15469032. [PubMed: 15469032]

Amico KR. Percent total attrition: a poor metric for study rigor in hosted intervention designs. Am J Public Health. 2009 Sep;99(9):1567–75. doi: 10.2105/ajph.2008.134767. PMID: 19608965. [PMC free article: PMC2724469] [PubMed: 19608965] [CrossRef]

Sen S, Prabhu M. Reporting bias in industry-supported medication trials presented at the American Psychiatric Association meeting. J Clin Psychopharmacol. 2012 Jun;32(3):435. doi: https://dx​.doi.org/10​.1097/JCP.0b013e318253d737. PMID: 22561482. [PMC free article: PMC4013544] [PubMed: 22561482]

Turner EH, Matthews AM, Linardatos E, et al Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med. 2008 Jan 17;358(3):252–60. doi: https://dx​.doi.org/10.1056/NEJMsa065779. PMID: 18199864. [PubMed: 18199864]

Turner EH, Knoepflmacher D, Shapley L. Publication bias in antipsychotic trials: an analysis of efficacy comparing the published literature to the US Food and Drug Administration database. PLoS Medicine / Public Library of Science. 2012;9(3):e1001189. doi: https://dx​.doi.org/10​.1371/journal.pmed.1001189. PMID: 22448149. [PMC free article: PMC3308934] [PubMed: 22448149]

Driessen E, Hollon SD, Bockting CL, et al Does Publication Bias Inflate the Apparent Efficacy of Psychological Treatment for Major Depressive Disorder? A Systematic Review and Meta-Analysis of US National Institutes of Health-Funded Trials. PLoS ONE [Electronic Resource]. 2015;10(9):e0137864. doi: https://dx​.doi.org/10​.1371/journal.pone.0137864. PMID: 26422604. [PMC free article: PMC4589340] [PubMed: 26422604]