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FGF Signalling in Vertebrate Development
Mary Elizabeth Pownall and Harry V. Isaacs.
Author Information and AffiliationsAbstract
The fibroblast growth factors (FGFs) represent one of the relatively few families of extracellular signalling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that misregulation of this signalling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development. This review will explore examples from several vertebrate model organisms and include discussions of the role of FGF signalling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development, and the establishment of right–left asymmetry.
Contents
- Introduction
- FGF Ligands
- FGF Receptors
- Heparan Sulphate Proteoglycans
- FGF Signal Transduction
- Regulators
- Integration with Other Signalling Pathways
- Mesoderm Induction
- Neural Induction
- FGF Signalling and Posterior Neural Patterning
- FGF Signalling at the Isthmic Organizer
- FGF Signalling at the Anterior Neural Ridge
- Morphogenesis
- Somitogenesis
- FGF and Myogenesis
- Limb Development
- FGF and Left-Right Asymmetry
- Perspectives
- References
- About the Authors
- NLM CatalogRelated NLM Catalog Entries
- Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis.[Dev Dyn. 2000]Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis.Kettunen P, Laurikkala J, Itäranta P, Vainio S, Itoh N, Thesleff I. Dev Dyn. 2000 Nov; 219(3):322-32.
- Review Fibroblast growth factor signaling during early vertebrate development.[Endocr Rev. 2005]Review Fibroblast growth factor signaling during early vertebrate development.Böttcher RT, Niehrs C. Endocr Rev. 2005 Feb; 26(1):63-77.
- Sef is synexpressed with FGFs during chick embryogenesis and its expression is differentially regulated by FGFs in the developing limb.[Dev Dyn. 2005]Sef is synexpressed with FGFs during chick embryogenesis and its expression is differentially regulated by FGFs in the developing limb.Harduf H, Halperin E, Reshef R, Ron D. Dev Dyn. 2005 Jun; 233(2):301-12.
- Review A conserved role for the nodal signaling pathway in the establishment of dorso-ventral and left-right axes in deuterostomes.[J Exp Zool B Mol Dev Evol. 2008]Review A conserved role for the nodal signaling pathway in the establishment of dorso-ventral and left-right axes in deuterostomes.Duboc V, Lepage T. J Exp Zool B Mol Dev Evol. 2008 Jan 15; 310(1):41-53.
- Region- and stage-specific effects of FGFs and BMPs in chick mandibular morphogenesis.[Dev Dyn. 2002]Region- and stage-specific effects of FGFs and BMPs in chick mandibular morphogenesis.Mina M, Wang YH, Ivanisevic AM, Upholt WB, Rodgers B. Dev Dyn. 2002 Mar; 223(3):333-52.
- FGF Signalling in Vertebrate DevelopmentFGF Signalling in Vertebrate Development
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