TABLE 3.1

NMDA–D1 and NMDA–D2 Receptor Interactions

PreparationRegionEffectMechanismReferences
NMDA–D1 Receptor Interactions
Brain slices, oocytesStriatum↑ NMDA responsescAMP–PKA–DARPP-32 [31, 32, 36, 43, 42]
Dissociated cellsCortexCa2+ [37, 44, 45, 46]
Brain slicesN. AccumbensD1/5↑ NMDA responsesPKC, Ca2+, PKA [38, 35, 112]
Dissociated cellsCortex
Cell culturesStriatum↑ D1receptors in spinesCa2+-dependent [52]
Organotypic culturesStriatum↑ D1receptors in spinesAllosteric change, diffusion trap [53]
HEK293, cell culturesHippocampus↓ NMDA currents
↓ Excitotoxicity
D1-NR2A binding
D1-NR1 binding
[49]
HEK293, COS7, PSDStriatumTranslocation of D1-NR1
↓ D1 agonist- induced internalization
Oligomerization D1-NR1 [57]
Synaptosomes from brain slicesStriatum↑ NR1, NR2A, NR2B in synaptosomesFyn protein tyrosine kinase [55, 56]
NMDA-D2 Receptor Interactions
Brain slicesStriatum↓ NMDA responses↓ cAMP, Ca2+? [32]
Cortex↓ NMDA responsesActivation of GABAA receptors [46]
Brain slicesCortexD4 ↓ NMDA responses↓ PKA, CaM kinase II [69]
Brain slicesHippocampusD4 ↓ NMDA responsesPDGF β [70]
CortexD2/3 ↓ NMDA responsesPDGF β [71]

From: Chapter 3, NMDA and Dopamine: Diverse Mechanisms Applied to Interacting Receptor Systems

Cover of Biology of the NMDA Receptor
Biology of the NMDA Receptor.
Van Dongen AM, editor.
Boca Raton (FL): CRC Press/Taylor & Francis; 2009.
Copyright © 2009, Taylor & Francis Group, LLC.

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