This book is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits others to distribute the work, provided that the article is not altered or used commercially. You are not required to obtain permission to distribute this article, provided that you credit the author and journal.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

StatPearls [Internet].
Show detailsContinuing Education Activity
Losartan is an angiotensin receptor blocker (ARB) approved by the US Food and Drug Administration (FDA) for the treatment of several medical conditions, including hypertension and diabetic nephropathy. Losartan inhibits angiotensin II–induced vasopressin release, adrenal catecholamine release, rapid and slow pressor responses, thirst, cellular hypertrophy and hyperplasia, noradrenergic neurotransmission, and sympathetic tone increase.
In addition, losartan inhibits angiotensin II–induced vasoconstriction and the effects of aldosterone, thereby lowering blood pressure. ARBs exhibit renoprotective effects in type 2 diabetes. In hypertension with left ventricular hypertrophy, losartan inhibits angiotensin II-induced cardiac remodeling, consequently reducing the risk of stroke in these patients. This activity reviews the use of losartan, including indications, mechanism of action, contraindications, pharmacokinetics, adverse event profiles, eligible patient populations, and monitoring. This activity also highlights the critical role of the interprofessional healthcare team in managing hypertension and diabetic nephropathy with losartan.
Objectives:
- Identify appropriate indications for losartan therapy, including hypertension and diabetic nephropathy, based on patient-specific clinical presentations and guidelines.
- Implement appropriate dosing strategies for losartan based on patient-specific factors, such as renal function and comorbidities.
- Apply knowledge of potential adverse effects of losartan, including hyperkalemia and angioedema, to promptly recognize and manage adverse reactions.
- Collaborate with other healthcare team members to ensure comprehensive care for patients prescribed losartan when managing complex cases involving losartan therapy to optimize patient outcomes.
Indications
FDA-Approved Indications
Losartan is an angiotensin receptor blocker (ARB) approved by the US Food and Drug Administration (FDA) for the treatment of several medical conditions, including hypertension and diabetic nephropathy.
Hypertension: ARBs such as losartan are first-line therapy for stage 1 hypertension, as are thiazide diuretics, calcium channel blockers, and angiotensin-converting enzyme inhibitors (ACEis). In patients with atherosclerotic cardiovascular disease (ASCVD) risk greater than or equal to 10%, combination therapy is used to maintain blood pressure. ARB II is useful as monotherapy in the absence of comorbidities such as diabetes, cerebrovascular disease, ischemic heart disease, heart failure, and chronic kidney disease.[1]
Diabetic nephropathy: In patients with type 2 diabetes and hypertension, losartan treats diabetic nephropathy with increased serum creatinine (SCr) and proteinuria. ARBs are renoprotective in type 2 diabetes.[2]
Hypertension with left ventricular hypertrophy: In hypertension with left ventricular hypertrophy, losartan inhibits angiotensin II-induced cardiac remodeling, consequently reducing the risk of stroke in these patients.
Off-Label Uses
Losartan is used for Marfan syndrome, acute coronary syndrome, stable coronary artery disease, and intolerance to ACEis.[3] A study involving older patients with heart failure, the Evaluation of Losartan in the Elderly Study (ELITE), concluded that compared to captopril, losartan correlated with lower mortality and was tolerated better than captopril.[4] The ELITE II study concluded that losartan was as competent as captopril in improving heart failure-related outcomes, the New York Heart Association (NYHA) functional class, and quality of life.[5]
According to the joint American Heart Association (AHA)/American College of Cardiology (ACC)/Heart Failure Society of America (HFSA) guidelines published in 2022, ARBs, such as losartan, are acknowledged as essential components of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) left ventricular ejection fraction (LVEF ≤40%).[6] As per 2023 guidelines by ACC/AHA, ARBs are also considered for managing heart failure with preserved ejection fraction (HFpEF - LVEF >50%).[7]
Mechanism of Action
Angiotensinogen is converted to angiotensin I by an enzyme, renin, released from the kidney's juxtaglomerular apparatus. ACE converts angiotensin I, an inactive decapeptide, to angiotensin II, an active octapeptide. Losartan is a selective and competitive ARB II at the AT1 receptor site, resulting in a compensatory elevation of renin and angiotensin I levels. The drug binds with high affinity to the AT1 receptor and is more than 10000 fold more selective for the AT1 receptor than the AT2 receptor.
Losartan inhibits angiotensin II–induced vasopressin release, adrenal catecholamine release, rapid and slow pressor responses, thirst, cellular hypertrophy and hyperplasia, noradrenergic neurotransmission, and sympathetic tone increase. In addition, losartan inhibits angiotensin II–induced vasoconstriction and the effects of aldosterone, thereby lowering blood pressure. Losartan increases the urinary flow and excretion of sodium, potassium, chloride, magnesium, uric acid, calcium, and phosphate. Compared to ACEi, ARB II effectively inhibits the renin-angiotensin system, not affecting the response to bradykinin.[8] For this reason, the non-renin-angiotensin effects, for example, cough and angioedema, are not commonly seen with ARBs.
Pharmacokinetics
Absorption: Losartan is well absorbed orally but undergoes extensive first-pass metabolism. The systemic bioavailability is approximately 33%. The onset of action of losartan is 6 hours and lasts approximately 24 hours.
Distribution: Losartan's plasma protein binding (PPB) is high, with approximately 98.7% of losartan bound to plasma proteins; the active metabolite E-3174 has a PPB of approximately 99.8%. The volume of distribution is around 34 L for losartan and 12 L for the metabolite.[9]
Metabolism: Hepatic P450 enzymes CYP2C9 and CYP3A4 metabolize losartan to a more potent 5-carboxylic acid metabolite, EXP 3174.[10]
Elimination: The half-lives of losartan and active metabolite (EXP 3174) are 1.5 to 2 hours and 6 to 9 hours, respectively. The plasma clearance of losartan and EXP 3174 are through the kidney and liver, respectively. Neither losartan nor the metabolite accumulates in the body at therapeutic doses.
Administration
Available Dosage Forms and Strengths
Losartan does not interact with the intake of food. The drug is well absorbed but slower with food. However, the administration is best when given at about the same time daily.[11] The FDA has approved the fixed drug combination of losartan/hydrochlorothiazide.[12][13] Losartan/hydrochlorothiazide combination medication has 3 strengths—50/12.5 mg, 100/12.5 mg, and 100/25 mg.
Adult Dosage
Hypertension: The typical initial dosage for losartan potassium tablets in adults is 50 mg daily. The losartan dosage can be increased to a maximum of 100 mg daily. However, for patients who may have low intravascular volume and are already on diuretic therapy, a lower starting dose of 25 mg is recommended. The American College of Rheumatology suggests losartan as the preferred anti-hypertensive drug for patients with gout and hypertension.[14]
Heart failure: According to ACC/AHA 2022 guidelines, the recommended starting dosage of losartan is 25 to 50 mg daily. The target dosage is 50 to 150 mg daily.[6]
Diabetic nephropathy: The starting dosage of losartan in diabetic nephropathy is 50 mg daily. Based on the patient's response, the losartan dosage may be titrated to 100 mg daily.
Specific Patient Populations
Hepatic impairment: The recommended initial dosage of losartan is 25 mg for patients with mild-to-moderate hepatic impairment. Losartan and its active metabolite concentrations may be higher in these patients than in healthy volunteers. Losartan has not been investigated in patients with severe hepatic impairment.
Renal impairment: Patients with renal insufficiency may have higher concentrations of losartan and its active metabolite than normal renal function. Dosage adjustment is generally only necessary if the patient is also volume-depleted.
Pregnancy considerations: Neonates with a history of in-utero exposure to losartan should be observed for hypotension, oliguria, and hyperkalemia. If these complications occur, clinicians should provide supportive measures to support blood pressure and renal function, including the consideration of exchange transfusions or dialysis. As per the guidelines provided by the American College of Obstetricians and Gynecologists (ACOG), avoiding exposure to ARBs during the first trimester of pregnancy is advised. ARBs are fetopathic and increase the risk of congenital malformations, including renal dysgenesis, calvarial hypoplasia, and fetal growth restriction. For additional information, refer to the Box Warning section.[15]
Breastfeeding considerations: Due to the lack of available information regarding the use of losartan during breastfeeding, it is advisable to consider alternative medications, particularly when nursing a newborn or preterm infant.[16]
Pediatric patients: The effectiveness and safety of losartan have been established in pediatric patients with hypertension aged 6 to 16. However, losartan's use is unproven in patients under 6 or with glomerular filtration (GFR) less than 30 mL/min/1.73 m². For children with hypertension, the recommended starting dosage is 0.7 mg/kg (up to a maximum of 50 mg) daily, administered either as a tablet or suspension. The dosage should be adjusted based on the response to blood pressure. Higher doses exceeding 1.4 mg/kg (or above 100 mg) per day have not been studied in pediatric patients.
Older patients: No significant differences in effectiveness or safety have been observed between older patients (65 and older) and younger patients in controlled clinical studies. However, older individuals may display greater sensitivity to the medication. The healthcare provider should consider initiating losartan at a low dose and assessing for comorbidities and polypharmacy in the patient.
Adverse Effects
The primary adverse effects of losartan, including hyperkalemia, renal insufficiency, and angioedema, are reported.[17]
Greater than 10%: Adverse effects greater than 10% include fatigue, hypoglycemia, anemia, urinary tract infection, chest pain, weakness, diarrhea, and cough (although the incidence of a cough is lower compared to ACEi therapy).
Between 1% and 10%: Adverse effects occurring between 1% and 10% include upper respiratory tract infection, hypotension, dizziness, cellulitis, gastritis, and nausea.
Frequently not defined/post-marketing surveillance: The potential adverse effects frequently not defined during post-marketing surveillance include angioedema,[18] edema/swelling, hypotension in hypovolemic patients, asthenia, headache, malaise, nausea, abdominal pain, hyperkalemia, back pain, worsening renal failure, tremors, and dysarthria.[19]
Contraindications
Losartan is contraindicated in hypersensitivity to losartan or any of its components.
Drug-Drug Interactions
Drugs causing hyperkalemia: When losartan is coadministered with other drugs that can increase serum potassium levels, it may lead to hyperkalemia. Clinicians should monitor serum potassium levels.
Lithium: Simultaneous use of lithium and ARBs, including losartan, is associated with elevated serum lithium concentrations and toxicity. Regular monitoring of serum lithium levels is recommended.
Nonsteroidal anti-inflammatory drugs (NSAIDs): In older patients with volume depletion, those on diuretic therapy, or individuals with impaired renal function, the coadministration of NSAIDs, including selective COX-2 inhibitors, with ARBs such as losartan, may result in a decline in renal function, including potential acute kidney injury. These effects are typically reversible. Periodic monitoring of renal function is advised for patients receiving losartan in combination with NSAIDs. NSAIDs can decrease the antihypertensive effects of ARB II, including losartan.
Dual blockade of the renin-angiotensin system: Concurrent use of ARBs, ACEi, or aliskiren (renin inhibitor) in combination is associated with increased risks of hypotension, syncope, hyperkalemia, and acute kidney injury compared to monotherapy.[20]
Aliskiren: In patients with diabetes, the coadministration of aliskiren with losartan is not recommended.[21] Additionally, aliskiren with losartan should be avoided in patients with renal impairment (GFR <60 mL/min).
Box Warning
Pregnancy: Losartan is contraindicated in pregnancy. As losartan acts on the renin-angiotensin system, it causes oligohydramnios, resulting in fetal lung hypoplasia and skeletal deformities. Potential neonatal adverse effects are skull hypoplasia, hypotension, anuria, renal failure, and death. Therefore, therapy with the drug should be discontinued when pregnancy is detected.[22]
Warnings and Precautions
Angioedema: The incidence of angioedema and cough with ARBs is less than ACEi. However, this may involve the airway and intestine, causing abdominal pain. Patients with previous episodes of angioedema associated with ACEi, hereditary angioedema, or idiopathic angioedema may have augmented risk. Frequent monitoring is necessary for such patients. Losartan should be discontinued if any episode of angioedema occurs, and the patient should be treated aggressively with intramuscular epinephrine. Patients should not be restarted on losartan after experiencing angioedema.[23]
Hyperkalemia: Risk factors include using potassium-sparing diuretics, potassium supplements, and potassium salts. In such cases, potassium levels should be monitored closely.
Hypotension: Healthcare providers should consider initiating losartan at a low dose and assessing for comorbidities and polypharmacy in the patient.
Renal function: Losartan may diminish renal function, resulting in elevated SCr levels, oliguria, azotemia, and acute renal failure. Losartan should be discontinued if a critical decrease in renal function is observed. It should be used cautiously in cases of renal artery stenosis and avoided altogether in bilateral renal artery stenosis.
Hepatic and renal impairment: Losartan should be cautiously used in patients with previous or current hepatic and renal impairment.
Monitoring
Healthcare providers should monitor blood pressure, renal function (blood urea nitrogen and SCr levels), and potassium levels in patients prescribed losartan.[24]
Heart failure: In cases of heart failure, healthcare providers should reevaluate the patient's blood pressure, including orthostatic measurements, renal function, and serum potassium levels. Patients with hyponatremia, systolic blood pressure (SBP) below 80 mm Hg, diabetes, and impaired renal function require close monitoring. According to the ACC/AHA/HFSA 2022 guidelines, healthcare providers should monitor BNP/NT-ProBNP levels for risk stratification.[6]
Hypertension: For confirmed hypertension with known cardiovascular disease (CVD) or patients with a 10-year ASCVD risk ≥10%, the recommended blood pressure target is less than 130/80 mm Hg. The ACC and AHA recommend a thorough follow-up evaluation for cardiovascular patients, which includes assessing blood pressure control, orthostatic hypotension, medication adverse effects, medication and lifestyle modification, dosage adjustments, laboratory testing, and target organ damage assessments. These evaluations are essential for the effective management of hypertension.[25]
Diabetes and hypertension: Per the guidelines of the American Diabetes Association, it is not recommended to discontinue ARBs in cases of minor increases in SCr levels (<30%) unless concurrent volume depletion exists.[26] The treatment goal for individuals aged 18 to 65 is to achieve a SBP below 140 mm Hg and a diastolic blood pressure (DBP) below 90 mm Hg. The goal for patients aged 18 to 65 at high risk of CVD is SBP less than 130 mm Hg and DBP less than 80 mm Hg if this is achievable without undue treatment burden. For patients aged 65 and older who are healthy or of complex/intermediate health, the goal of therapy is SBP less than 140 mm Hg and DBP greater than 90 mm Hg. The goal of treatment for patients aged 65 and older and of very complex or poor health is SBP less than 150 mm Hg and DBP less than 90 mm Hg.
Toxicity
In a recent case report, a female patient aged 34 with a medical history of asthma, hypertension, and chronic respiratory failure had an overdose of losartan. She intentionally ingested 30 tablets of 25 mg of losartan in a suicide attempt. Illicit substance use was ruled out through a negative urine drug screen. During her hospitalization, the patient developed acute kidney injury and hyperkalemia. Based on the patient's complaint of diffuse abdominal pain, elevated lipase levels (161 U/L), and computed tomography (CT) imaging findings, acute pancreatitis was diagnosed. Supportive care, including fluid resuscitation, pain management, and continuous monitoring of laboratory parameters, was provided, gradually improving her condition. The healthcare team should be mindful of the possibility of drug-induced acute pancreatitis following an overdose of losartan from acute kidney injury and hyperkalemia.[27]
No consensus recommendation for overdosing on ARBs exists. The chronic use of ARBs at standard doses can block the renin-angiotensin and sympathetic nervous systems, leading to shock that may not respond to catecholamines. In cases of refractory shock, vasopressin can be considered.[28] No antidote for losartan is available, and hemodialysis is ineffective in removing losartan from circulation due to the high PPB, as mentioned in pharmacokinetics. Supportive care should be instituted for overdose cases.
Enhancing Healthcare Team Outcomes
Although any clinician can prescribe losartan for hypertension and diabetic nephropathy, regular monitoring of renal function and blood pressure by the interprofessional healthcare team is essential. Input from heart failure specialists or cardiologists regarding GDMT is recommended for evidence-based treatment. Losartan is effective for hypertension and can be incorporated into long-term therapy plans, but its optimal use still necessitates the participation of an interprofessional team to optimize treatment outcomes.
When initially prescribed, a pharmacist must verify appropriate dosing, conduct medication reconciliation, and counsel the patient regarding losartan. Nursing staff also play a crucial role in offering valuable patient counseling, addressing inquiries, and evaluating therapeutic effectiveness during subsequent visits. The pharmacist or nursing staff should promptly communicate any concerns to the prescriber to facilitate timely therapeutic adjustments through shared decision-making. In cases of overdose, consultation with a medical toxicologist is recommended. An interprofessional team approach, fostering open communication among physicians, advanced practice practitioners, specialists, nurses, pharmacists, and toxicologists, is pivotal in optimizing patient outcomes while mitigating potential adverse effects associated with losartan therapy.
References
- 1.
- Al-Majed AR, Assiri E, Khalil NY, Abdel-Aziz HA. Losartan: Comprehensive Profile. Profiles Drug Subst Excip Relat Methodol. 2015;40:159-94. [PubMed: 26051686]
- 2.
- Ruggenenti P. Dual renin-angiotensin system blockade for nephroprotection. Nephrol Ther. 2017 Apr;13 Suppl 1:S43-S45. [PubMed: 28577742]
- 3.
- den Hartog AW, Franken R, van den Berg MP, Zwinderman AH, Timmermans J, Scholte AJ, de Waard V, Spijkerboer AM, Pals G, Mulder BJ, Groenink M. The effect of losartan therapy on ventricular function in Marfan patients with haploinsufficient or dominant negative FBN1 mutations. Neth Heart J. 2016 Nov;24(11):675-681. [PMC free article: PMC5065542] [PubMed: 27704402]
- 4.
- Pitt B, Segal R, Martinez FA, Meurers G, Cowley AJ, Thomas I, Deedwania PC, Ney DE, Snavely DB, Chang PI. Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE). Lancet. 1997 Mar 15;349(9054):747-52. [PubMed: 9074572]
- 5.
- Konstam MA, Neaton JD, Poole-Wilson PA, Pitt B, Segal R, Sharma D, Dasbach EJ, Carides GW, Dickstein K, Riegger G, Camm AJ, Martinez FA, Bradstreet DC, Ikeda LS, Santoro EP., ELITE II Investigators. Comparison of losartan and captopril on heart failure-related outcomes and symptoms from the losartan heart failure survival study (ELITE II). Am Heart J. 2005 Jul;150(1):123-31. [PubMed: 16084158]
- 6.
- Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW., ACC/AHA Joint Committee Members. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022 May 03;145(18):e895-e1032. [PubMed: 35363499]
- 7.
- Kittleson MM, Panjrath GS, Amancherla K, Davis LL, Deswal A, Dixon DL, Januzzi JL, Yancy CW. 2023 ACC Expert Consensus Decision Pathway on Management of Heart Failure With Preserved Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2023 May 09;81(18):1835-1878. [PubMed: 37137593]
- 8.
- He YM, Feng L, Huo DM, Yang ZH, Liao YH. Enalapril versus losartan for adults with chronic kidney disease: a systematic review and meta-analysis. Nephrology (Carlton). 2013 Sep;18(9):605-14. [PubMed: 23869492]
- 9.
- Ripley E, Hirsch A. Fifteen years of losartan: what have we learned about losartan that can benefit chronic kidney disease patients? Int J Nephrol Renovasc Dis. 2010;3:93-8. [PMC free article: PMC3108782] [PubMed: 21694934]
- 10.
- LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases; Bethesda (MD): Jan 13, 2017. Losartan. [PubMed: 31643181]
- 11.
- Dickstein K, Timmermans P, Segal R. Losartan: a selective angiotensin II type 1 (AT1) receptor antagonist for the treatment of heart failure. Expert Opin Investig Drugs. 1998 Nov;7(11):1897-914. [PubMed: 15991937]
- 12.
- Kjeldsen SE, Lyle PA, Kizer JR, Oparil S, Høieggen A, Os I. Fixed combination of losartan and hydrochlorothiazide and reduction of risk of stroke. Vasc Health Risk Manag. 2007;3(3):299-305. [PMC free article: PMC2293966] [PubMed: 17703637]
- 13.
- Ueda T, Kai H, Imaizumi T., MAPPY Study Investigators. Losartan/hydrochlorothiazide combination vs. high-dose losartan in patients with morning hypertension--a prospective, randomized, open-labeled, parallel-group, multicenter trial. Hypertens Res. 2012 Jul;35(7):708-14. [PubMed: 22399096]
- 14.
- FitzGerald JD, Dalbeth N, Mikuls T, Brignardello-Petersen R, Guyatt G, Abeles AM, Gelber AC, Harrold LR, Khanna D, King C, Levy G, Libbey C, Mount D, Pillinger MH, Rosenthal A, Singh JA, Sims JE, Smith BJ, Wenger NS, Bae SS, Danve A, Khanna PP, Kim SC, Lenert A, Poon S, Qasim A, Sehra ST, Sharma TSK, Toprover M, Turgunbaev M, Zeng L, Zhang MA, Turner AS, Neogi T. 2020 American College of Rheumatology Guideline for the Management of Gout. Arthritis Rheumatol. 2020 Jun;72(6):879-895. [PubMed: 32390306]
- 15.
- American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics. ACOG Practice Bulletin No. 203: Chronic Hypertension in Pregnancy. Obstet Gynecol. 2019 Jan;133(1):e26-e50. [PubMed: 30575676]
- 16.
- Drugs and Lactation Database (LactMed®) [Internet]. National Institute of Child Health and Human Development; Bethesda (MD): Nov 15, 2024. Losartan. [PubMed: 30000685]
- 17.
- Bolotova O, Yoo J, Chaudhri I, Marcos LA, Sahib H, Koraishy FM, Skopicki H, Ahmad S, Mallipattu SK. Safety, tolerability, and outcomes of losartan use in patients hospitalized with SARS-CoV-2 infection: A feasibility study. PLoS One. 2020;15(12):e0244708. [PMC free article: PMC7773257] [PubMed: 33378401]
- 18.
- Vedantam V, Magacha HM, Vedantam N, Dahya V, Abu-Heija U. A Case Report of Losartan Induced Angioedema. Cureus. 2023 Mar;15(3):e36525. [PMC free article: PMC10120880] [PubMed: 37090415]
- 19.
- Fishman TJ, Degu TA, Sun L, Salabei JK. Possible Association of Tremors and Dysarthria with Losartan Use: A Case Report. Cureus. 2019 Dec 13;11(12):e6374. [PMC free article: PMC6957050] [PubMed: 31938654]
- 20.
- Esteras R, Perez-Gomez MV, Rodriguez-Osorio L, Ortiz A, Fernandez-Fernandez B. Combination use of medicines from two classes of renin-angiotensin system blocking agents: risk of hyperkalemia, hypotension, and impaired renal function. Ther Adv Drug Saf. 2015 Aug;6(4):166-76. [PMC free article: PMC4530349] [PubMed: 26301070]
- 21.
- Woo KT, Choong HL, Wong KS, Tan HK, Foo M, Fook-Chong S, Lee EJ, Anantharaman V, Lee GS, Chan CM. Aliskiren and losartan trial in non-diabetic chronic kidney disease. J Renin Angiotensin Aldosterone Syst. 2014 Dec;15(4):515-22. [PubMed: 24742970]
- 22.
- Daïkha-Dahmane F, Levy-Beff E, Jugie M, Lenclen R. Foetal kidney maldevelopment in maternal use of angiotensin II type I receptor antagonists. Pediatr Nephrol. 2006 May;21(5):729-32. [PubMed: 16565869]
- 23.
- Mathey CM, Maj C, Scheer AB, Fazaal J, Wedi B, Wieczorek D, Amann PM, Löffler H, Koch L, Schöffl C, Dickel H, Ganjuur N, Hornung T, Forkel S, Greve J, Wurpts G, Hallberg P, Bygum A, Von Buchwald C, Karawajczyk M, Steffens M, Stingl J, Hoffmann P, Heilmann-Heimbach S, Mangold E, Ludwig KU, Rasmussen ER, Wadelius M, Sachs B, Nöthen MM, Forstner AJ. Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes. Front Genet. 2022;13:914376. [PMC free article: PMC9339951] [PubMed: 35923707]
- 24.
- Comparison chart: Some drugs for HFrEF. Med Lett Drugs Ther. 2021 Jun 14;63(1626):e1-e14. [PubMed: 34181629]
- 25.
- Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Dennison Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, MacLaughlin EJ, Muntner P, Ovbiagele B, Smith SC, Spencer CC, Stafford RS, Taler SJ, Thomas RJ, Williams KA, Williamson JD, Wright JT. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018 May 15;71(19):e127-e248. [PubMed: 29146535]
- 26.
- American Diabetes Association Professional Practice Committee. 11. Chronic Kidney Disease and Risk Management: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022 Jan 01;45(Suppl 1):S175-S184. [PubMed: 34964873]
- 27.
- Khatri S, Chacko S, Chamay S, Kashfi S, Sharma S. Delayed-Onset Losartan-Induced Pancreatitis Secondary to an Overdose: A Case Report. J Investig Med High Impact Case Rep. 2023 Jan-Dec;11:23247096231165737. [PMC free article: PMC10102932] [PubMed: 37052072]
- 28.
- Matsushime S, Kuriyama A. Vasopressin for persistent hypotension due to amlodipine and olmesartan overdose: A case report. Ann Med Surg (Lond). 2021 May;65:102292. [PMC free article: PMC8082198] [PubMed: 33981424]
Disclosure: Sana Mulla declares no relevant financial relationships with ineligible companies.
Disclosure: Preeti Patel declares no relevant financial relationships with ineligible companies.
Disclosure: Waqas Siddiqui declares no relevant financial relationships with ineligible companies.
- Chronic losartan treatment decreases angiotensin II-mediated facilitation of noradrenaline release in the caudal artery of spontaneously hypertensive rats.[Life Sci. 2000]Chronic losartan treatment decreases angiotensin II-mediated facilitation of noradrenaline release in the caudal artery of spontaneously hypertensive rats.Ruiz-Gayo M, Somoza B, Bravo R, Fernández-Alfonso MS, González C. Life Sci. 2000 Nov 17; 67(26):3153-62.
- Review Emerging trends for prevention and treatment of diabetic nephropathy: blockade of the RAAS and BP control.[J Manag Care Pharm. 2004]Review Emerging trends for prevention and treatment of diabetic nephropathy: blockade of the RAAS and BP control.Hunsicker LG. J Manag Care Pharm. 2004 Sep; 10(5 Suppl A):S12-7.
- KT3-671, an angiotensin AT1 receptor antagonist, attenuates vascular but not cardiac responses to sympathetic nerve stimulation in pithed rats.[J Cardiovasc Pharmacol. 2001]KT3-671, an angiotensin AT1 receptor antagonist, attenuates vascular but not cardiac responses to sympathetic nerve stimulation in pithed rats.Takata Y, Kurihara J, Yoda T, Suzuki S, Matsuoka Y, Okubo Y, Kato H. J Cardiovasc Pharmacol. 2001 Apr; 37(4):427-36.
- Effect of the AT1-receptor antagonists losartan, irbesartan, and telmisartan on angiotensin II-induced facilitation of sympathetic neurotransmission in the rat mesenteric artery.[J Cardiovasc Pharmacol. 2001]Effect of the AT1-receptor antagonists losartan, irbesartan, and telmisartan on angiotensin II-induced facilitation of sympathetic neurotransmission in the rat mesenteric artery.Balt JC, Mathy MJ, Nap A, Pfaffendorf M, van Zwieten PA. J Cardiovasc Pharmacol. 2001 Jul; 38(1):141-8.
- Review Clinical pharmacokinetics of angiotensin II (AT1) receptor blockers in hypertension.[J Hum Hypertens. 2000]Review Clinical pharmacokinetics of angiotensin II (AT1) receptor blockers in hypertension.Israili ZH. J Hum Hypertens. 2000 Apr; 14 Suppl 1:S73-86.
- Losartan - StatPearlsLosartan - StatPearls
Your browsing activity is empty.
Activity recording is turned off.
See more...