Table 7. Likelihood of significant coronary artery disease in patients with symptoms suggesting unstable angina

High likelihood
(e.g., 0.85-0.99)
Intermediate likelihood
(e.g., 0.15-0.84)
Low likelihood
(e.g., 0.01-0.14)
Any of the high or following features: Absence of high likelihood features and any of the following: Absence of intermediate likelihood features but may have:
History of prior MI or sudden death or other known history of CAD
Definite angina: males > 60 or females > 70 years of age
Transient hemodynamic or ECG changes during pain
Definite angina: males < 60 or females < 70 years of age
Probable angina: males > 60 or females > 70 years of age
Chest pain probably not angina in patients with diabetes
Chest pain classified as probably not angina
One risk factor other than diabetes
T-wave flattening or inversion < 1 mm in leads with dominant R waves
Variant angina (pain with reversible ST-segment elevation) Chest pain probably not angina and two or three risk factors other than diabetes[1] Normal ECG
ST segment elevation or depression > 1 mm
Marked symmetrical T-wave inversion in multiple precordial leads
Extracardiac vascular disease
ST depression 0.05 to 1 mm
T-wave inversion > 1 mm in leads with dominant R-waves

[1] Coronary artery disease risk factors include diabetes, smoking, hypertension, and elevated cholesterol.

Note: Estimation of the likelihood of significant coronary artery disease is a complex, multivariable problem that cannot be fully specified in a table such as this. Therefore, the table is meant to illustrate major relationships rather than offer rigid algorithms.

From: 3, Guideline: Outpatient Care

Cover of Unstable Angina: Diagnosis and Management
Unstable Angina: Diagnosis and Management.
AHCPR Clinical Practice Guidelines, No. 10.
Braunwald E, Mark DB, Jones RH.

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