FIGURE 10.1. The self-administration of an escalating dose regimen of i.

FIGURE 10.1

The self-administration of an escalating dose regimen of i.v. morphine infusion by 21 rats under a contingent FR1 schedule of reinforcement with 50-sec timeouts. Access to the reinforcement response lever was available 24 hr per day. (a) The dose of morphine self-administered with each infusion. The integers above the panel indicate the number of animals completing the regimen to that point. (b) The number of reinforcement lever responses per 24 hr. (c) The number of morphine infusions as a consequence of contingent lever responses per 24 hr. (d) The dose of morphine self-administered per 24 hr. Error bars refer to the SEM.

From: Chapter 10, Contextually Induced Drug Seeking During Protracted Abstinence in Rats

Cover of Methods of Behavior Analysis in Neuroscience
Methods of Behavior Analysis in Neuroscience. 2nd edition.
Buccafusco JJ, editor.
Boca Raton (FL): CRC Press/Taylor & Francis; 2009.
Copyright © 2009, Taylor & Francis Group, LLC.

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