FIGURE 16.1. (a) Images of Aβ-induced paralysis in the transgenic CL4176 strain without transgene expression (no Aβ), untreated with EGb 761 (Ctrl, left panel), and in the transgenic CL4176 strain (muscle Aβ strain) fed with (EGb, right) or without EGb 761 (Ctrl, middle) at 36 hr after temperature up-shift.

FIGURE 16.1

(a) Images of Aβ-induced paralysis in the transgenic CL4176 strain without transgene expression (no Aβ), untreated with EGb 761 (Ctrl, left panel), and in the transgenic CL4176 strain (muscle Aβ strain) fed with (EGb, right) or without EGb 761 (Ctrl, middle) at 36 hr after temperature up-shift. (b) Schematic diagram of the chemotaxis assay. Worms are transferred to the center of the plate. After attractant and control odorant mixed with sodium azide are dropped on the plate, C. elegans start to move toward odorant source until they are paralyzed by sodium azide.

From: Chapter 16, Caenorhabditis elegans Model for Initial Screening and Mechanistic Evaluation of Potential New Drugs for Aging and Alzheimer’s Disease

Cover of Methods of Behavior Analysis in Neuroscience
Methods of Behavior Analysis in Neuroscience. 2nd edition.
Buccafusco JJ, editor.
Boca Raton (FL): CRC Press/Taylor & Francis; 2009.
Copyright © 2009, Taylor & Francis Group, LLC.

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