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Buccafusco JJ, editor. Methods of Behavior Analysis in Neuroscience. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2009.

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Methods of Behavior Analysis in Neuroscience. 2nd edition.

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The Editor

Jerry J. Buccafusco, Ph.D., is Director of the Alzheimer’s Research Center in the Department of Pharmacology and Toxicology of the Medical College of Georgia. He holds the ranks of Professor of Pharmacology and Toxicology and Professor of Psychiatry and Health Behavior. He holds a joint appointment as Research Pharmacologist and Director of the Neuropharmacology Laboratory at the Department of Veterans Affairs Medical Center. Dr. Buccafusco is also president and CEO (and founder, est. 03/01/2000) of Prime Behavior Testing Laboratories, Inc. (Evans, GA), a contract research company for the preclinical evaluation of cognition-enhancing therapeutic agents.

Dr. Buccafusco was classically trained as a chemist, receiving the M.S. degree in inorganic chemistry from Canisius College in 1973. His pharmacological training was initiated at the University of Medicine and Dentistry of New Jersey where he received the Ph.D. degree in 1978. His doctoral thesis concerned the role of central cholinergic neurons in mediating a hypertensive state in rats. Part of this work included the measurement of several components of hypothalamically mediated escape behavior in this model. His postdoctoral experience included two years at the Roche Institute of Molecular Biology under the direction of Dr. Sydney Spector. In 1979 he joined the Department of Pharmacology and Toxicology of the Medical College of Georgia. In 1989 Dr. Buccafusco helped found and became the director of the Medical College of Georgia’s Alzheimer’s Research Center. The center hosts several core facilities, including the Animal Behavior Center, which houses more than 50 young and aged macaque monkeys who participate in cognitive research studies.

Awards and honors resulting from Dr. Buccafusco’s research include the New Investigator Award, National Institute on Drug Abuse, 1980; Sandoz Distinguished Lecturer, 1983; Distinguished Faculty Award for the Basic Sciences, School of Medicine (Medical College of Georgia), 1988; Callaway Foundation of Georgia, Center Grant recipient, 1989; and the Distinguished Alumnus Award, University of Medicine and Dentistry of New Jersey, 1998. In 2008, Dr. Buccafusco was appointed Veterans Administration Career Scientist, and he was the recipient of the American Society for Pharmacology and Therapeutics’ Pharmacia-ASPET Award for Experimental Therapeutics. Dr. Buccafusco also served as member of the Pharmacology II Study Section of the National Institute on Drug Abuse from 1989–1991. He is a member of the Scientific Advisory Board of the Institute for the Study of Aging, New York, NY, and is a consultant to several pharmaceutical companies in the area of neuropharmacology and drug discovery. Dr. Buccafusco holds memberships in several scientific societies. In the professional society, the American Society for Pharmacology and Experimental Therapeutics, he recently completed a three-year term as (inaugural) Chairman of the Division of Systems and Integrated Pharmacology. He also serves as Associate Editor (Neuro-Behavioral Pharmacology section) for the Journal of Pharmacology and Experimental Therapeutics.

Dr. Buccafusco has authored more than 200 research publications and book chapters. Over the years these articles have received more than 3000 citations by other authors. His research area includes the development of novel treatment modalities for Alzheimer’s disease and related disorders. In 1988, his laboratory was the first to report the cognitive enhancing action of low doses of nicotine in nonhuman primates. Since that time he has studied numerous novel memory-enhancing agents derived from several pharmacological classes in this model. His most recent work is directed at the development of single molecular entities that act on multiple CNS targets to not only enhance cognitive function, but also to provide neuroprotection or alter the disposition and metabolism of amyloid precursor protein. Dr. Buccafusco has also studied the toxic effects of organophosphorus anticholinesterases used as insecticides and chemical warfare agents. In particular, he has studied the behavioral/cognitive alterations associated with low level, chronic exposure to such agents. His work in the area of drug abuse has centered around the role of central cholinergic neurons in the development of physical dependence on opiates, and in the expression of acute and protracted withdrawal behaviors. Most recently, his laboratory is investigating the role of the immune system and in the production of autoantibodies to β-amyloid and to the receptor for advanced glycation end products (RAGE) by individuals with Alzheimer’s disease. These studies have been supported by continuous federally sponsored grants and by several private foundations and commercial interests.

Copyright © 2009, Taylor & Francis Group, LLC.
Bookshelf ID: NBK5218

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