FIGURE 7.4. Clozapine-evoked increase in population spike is blocked by the 5-HT1A-R antagonist WAY100635.

FIGURE 7.4

Clozapine-evoked increase in population spike is blocked by the 5-HT1A-R antagonist WAY100635. Prefrontal cortex (PFC) slices from P20–30 mice were stimulated as described in the methods. After obtaining a stable baseline of population spike (a), clozapine was added to the bath solution to a final concentration of 15 μM (b). The maximum increase in population spike (a plateau) was observed after 60 min of clozapine treatment (b and c). This clozapine-evoked increase in activity was completely eliminated when WAY (4 μM) was included in the bath solution before adding clozapine (c). The increase in neuronal activity could also be truncated before it reached a maximum by adding the 5-HT1A antagonist (WAY100635) 40 min after clozapine treatment (d).

From: Chapter 7, The 5-HT1A Receptor: A Signaling Hub Linked to Emotional Balance

Cover of Serotonin Receptors in Neurobiology
Serotonin Receptors in Neurobiology.
Chattopadhyay A, editor.
Boca Raton (FL): CRC Press/Taylor & Francis; 2007.
Copyright © 2007, Taylor & Francis Group, LLC.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.