Table 16.1. Advantages and Disadvantages of Three Poliovirus Vaccination Options

AttributeOPVIPVIPV-OPV
Occurrence of VAPP8-9 cases/yrNone2-5 cases/yr *
Other serious adverse eventsNone knownNone knownNone known
Systemic ImmunityHighHighHigh
Immunity of GI mucosaHighLowHigh
Secondary transmission of vaccine virusYesNoSome
Extra injections or visits neededNoYesYes
Compliance with immunization scheduleHighPossibly reducedPossibly reduced
Future combination vaccinesUnlikelyLikelyLikely (IPV)
Current costLowHigherIntermediate

* Estimated

Adapted from: Centers for Disease Control and Prevention. Poliomyelitis prevention in the United States: introduction of a sequential vaccination schedule of inactivated poliovirus vaccine followed by oral poliovirus vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 1997;46(No. RR-3):12.

From: 16, Poliomyelitis

Cover of Clinician's Handbook of Preventive Services
Clinician's Handbook of Preventive Services. 2nd edition.
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