| Class: Mood Disorders | √ | | √ |
| Class: Depressive Disorders | | √ | |
| Five or more of the following A Criteria (at least one includes A1 or A2) | √ | √ | √ |
| A1 Depressed mood—indicated by subjective report or observation by others (in children and adolescents, can be irritable mood). | √ | √ | √ |
| A2 Loss of interest or pleasure in almost all activities—indicated by subjective report or observation by others. | √ | √ | √ |
| A3 Significant (more than 5 percent in a month) unintentional weight loss/gain or decrease/increase in appetite (in children, failure to make expected weight gains). | √ | √ | √ |
| A4 Sleep disturbance (insomnia or hypersomnia). | √ | √ | √ |
| A5 Psychomotor changes (agitation or retardation) severe enough to be observable by others. | √ | √ | √ |
| A6 Tiredness, fatigue, or low energy, or decreased efficiency with which routine tasks are completed. | √ | √ | √ |
| A7 A sense of worthlessness or excessive, inappropriate, or delusional guilt (not merely self-reproach or guilt about being sick). | √ | √ | √ |
| A8 Impaired ability to think, concentrate, or make decisions—indicated by subjective report or observation by others. | √ | √ | √ |
| A9 Recurrent thoughts of death (not just fear of dying), suicidal ideation, or suicide attempts. | √ | √ | √ |
| The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. | √ | √ | √ |
| The symptoms are not due to the direct physiological effects of a substance (e.g., drug abuse, a prescribed medication’s side effects) or a medical condition (e.g., hypothyroidism). | √ | √ | |
| The symptoms do not meet criteria for a mixed episode (See ).3 | √ | | |
| There has never been a manic episode or hypomanic episode. | √ | √ | |
| MDE is not better explained by schizophrenia spectrum or other psychotic disorders. | √ | √ | |
| The symptoms are not better accounted for by bereavement (i.e., after the loss of a loved one, the symptoms persist for longer than 2 months or are characterized by marked functional impairment, morbid preoccupation with worthlessness, suicidal ideation, psychotic symptoms, or psychomotor retardation).4 | √ | | |