Table 1Substituted isoxazole carboxamides as potent STAT3 activators

Image ml115fu3.jpg
compoundRR′STAT3 EC50 (μM)
1a
Image ml115fu4.jpg
Image ml115fu5.jpg
0.002
1b
Image ml115fu6.jpg
-(CH2)2-CH30.008
1c
Image ml115fu7.jpg
-CH(CH3)20.001
1d
Image ml115fu8.jpg
-CH36.9
1e
Image ml115fu9.jpg
Image ml115fu10.jpg
0.005
1f
Image ml115fu11.jpg
Image ml115fu12.jpg
6.08
1g
Image ml115fu13.jpg
Image ml115fu14.jpg
>5.6

From: Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Activators)

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