10.11.5What are the diagnostic tests available for detection of toxoplasmosis infection and how do they compare in terms of specificity, sensitivity and cost effectiveness?

StudyRef.PopulationInterventionOutcomesResultsCommentsStudy typeEL
Cubitt et al., 1992474Sera from 1000 pregnant women booking for antenatal care at a London hospitalSerological screening for antibodies to toxoplasmosis with gold standard based on repeat testing resultsComparison of DA, LA and EIAs49/1000 discordant results among all assays and required repeat testing; 9 remained undetermined
EIAs: 0/773 false positives, 2/218 false negatives
LA: 0/218 false negatives, 1/773 false positives
DA: 0/218 false negative, 23/773 false positives

From: Evidence tables

Cover of Antenatal Care
Antenatal Care: Routine Care for the Healthy Pregnant Woman.
NICE Clinical Guidelines, No. 62.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2008 Mar.
Copyright © 2008, National Collaborating Centre for Women’s and Children’s Health.

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