10.9.2What is the prevalence of GBS infection in the neonate and what are the consequences of infection?

StudyRef.PopulationInterventionOutcomesResultsCommentsStudy typeEL
Fey et al., 1999437Neonates in England and Wales between 1995 and 1997Analysis of reports to CDSC and isolates submitted to laboratoriesRates of early onset (within first week of birth) disease
Rates of late onset (between 1 week and 3 months of age) disease
0.4/1000 live births
0.2/1000 live births
Marked under-reporting suspected, as one region where all laboratories contributed reports had rates of 0.7/1000 and 0.3/1000 for early and late onset, respectively
No actual numbers. Data from an abstract
Oddie and Embleton, 200243536 infants infected with GBS in the first week after birth out of 62,786 live births in the Northern health region of the UK from April 1998 to March 2000Survey (cross-checked with surveillance by PHLS)Isolation of GBS in infant during first week of life
Effect of GBS isolated during pregnancy as risk factor for early onset disease
Prevalence of 0.57 per 1000 live births (36 of 62,786 live births)
Adjusted OR 1.9 (95%CI 0.03, 142.7)
Health Protection Agency 2002431N = 537 confirmed cases of GBS in infants aged < 90 days, reported by paediatricians and microbiologists from Feb 2000 to 28 Feb 2001 in the UKSurveillance via the British Paediatric Surveillance Unit and cases reported by microbiologists to PHLS for typingIsolation of GBS from a normally sterile siteFrom 537 cases, 67% aged under 7 days (early-onset disease); 33% aged between 7 and 90 days (late-onset disease)
Overall mortality rate of 9.4%
Incidence for England: 0.8/1000 live births (95% CI 0.7 to 0.9); early-onset disease 0.5 (0.5 to 0.6)
Incidence for Wales: 0.6/1000 live births (0.4 to 0.9); early-onset disease 0.4 (0.2 to 0.7)
Most common presentations of early-onset disease: sepsis in 62%; pneumonia in 26%
Bignardi, 199943815 confirmed cases of neonatal GBS infection from January 1995 through December 1997 from among 10,525 live birthsPositive blood and CSF cultures that yielded GBS at Sunderland Royal Hospital from children under three months of ageIncidence of GBSNeonatal infection 1.42/1000 live births (95% CI 0.8 to 2.04)CSS3

From: Evidence tables

Cover of Antenatal Care
Antenatal Care: Routine Care for the Healthy Pregnant Woman.
NICE Clinical Guidelines, No. 62.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2008 Mar.
Copyright © 2008, National Collaborating Centre for Women’s and Children’s Health.

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