10.4.2What is the prevalence of congenital cytomegalovirus (CMV) infection?

StudyRef.PopulationInterventionOutcomesResultsCommentsStudy typeEL
Preece et al., 198637523,247 pregnant women
3 London hospitals
Dates not given
Infants diagnosed if CMV isolated from throat swab in first week of lifeEstimated prevalence of congenital CMV69/23,247
Prevalence 2.6/1000
Estimated denominator as not all women screenedCSS3
Peckham et al., 198337614,200 babies born at three London hospitals from Sep 1979 through Aug 1982Infants diagnosed if CMV isolated in first week of life from throat swabCongenital infection with CMV42 live births, rate of 3/1000
None of the 42 mothers had any signs or symptoms of acute CMV infection
26 had been positive at their first antenatal visit
Discrepancy between 14,789 mothers and 14,200 infants, i.e. approx 589 infants unaccounted forCS3

From: Evidence tables

Cover of Antenatal Care
Antenatal Care: Routine Care for the Healthy Pregnant Woman.
NICE Clinical Guidelines, No. 62.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2008 Mar.
Copyright © 2008, National Collaborating Centre for Women’s and Children’s Health.

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