Table 11.22Characteristics of included studies on diagnostic value of maternal serum CRP levels

Study and ELStudy characteristicsPopulation characteristicsSample size (% of study population)Timing of screening test with thresholdOutcome in weeksDiagnostic value with 95% CI
Hvilsom (2002)903
Nested case–control study, single centre, not blinded.Cases: women having idiopathic SPTB < 37 weeks.
Controls: randomly selected women who had term delivery
(84 cases, 400 controls) from a cohort of 2846 singleton pregnancies
Single test at 14–19 weeks (median 16.3 weeks).
Threshold 7.6 ng/ml
< 37ST 0.26 (0.17–0.36), SP 0.86 (0.82–0.89)
Karinen (2005)904
Nested case–control study, from population-based birth cohort, not blindedCases: women having idiopathic SPTB < 37 weeks
Controls: randomly selected women who had term delivery matched on age and parity
(104 cases, 402 controls) from a cohort of 2309 singleton pregnancies.
Single test in first trimester (mean age 10.4 weeks)
Threshold – 4.3 ng/ml
< 37ST 0.35 (0.26–0.45), SP 0.78 (0.73–0.82)

From: 11, Screening for clinical problems

Cover of Antenatal Care
Antenatal Care: Routine Care for the Healthy Pregnant Woman.
NICE Clinical Guidelines, No. 62.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2008 Mar.
Copyright © 2008, National Collaborating Centre for Women’s and Children’s Health.

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