Table 11.19Characteristics of included studies on diagnostic value of cervico-vaginal IL-8 levels

Study and ELStudy characteristicsPopulation characteristics (low or high risk)Sample size (% of study population)Timing and site of screening test with thresholdOutcome in weeks (incidence of SPTB)Diagnostic value with 95% CI
Sakai (2004)896 (Japan)
EL II
Prospective cohort, multicentre, not blinded.Singleton pregnancies
Exclusions: preterm labour at < 20 weeks, PROM, genital bleeding, abruptio placentae, placenta praevia, pre-eclampsia, fetal anomalies.
4203
(95.4%)
Serial testing – once a month in 20–23 weeks and then once biweekly in 24–28 weeks.
Threshold 360 ng/ml
(IL-8 positivity once in 19.1%)
< 32 (0.43%)
< 34 (0.64%)
37 (3.3%)
For SPTB < 37 weeks
ST 0.27 (0.20–0.36), SP 0.80 (0.79–0.81)
Sakai (2004)897 (Japan)
EL II
Prospective cohort, single centre, not blinded.Singleton pregnancies
Exclusions: preterm births caused by fetal asphyxia, abruptio placentae, placenta praevia, pre-eclampsia.
501
(study population not specified)
Single test at 20–24 weeks.
(377 ng/ml)
< 37
(5.2% in sample population)
ST 0.42 (0.23–0.63), SP 0.85 (0.81–0.88)

From: 11, Screening for clinical problems

Cover of Antenatal Care
Antenatal Care: Routine Care for the Healthy Pregnant Woman.
NICE Clinical Guidelines, No. 62.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2008 Mar.
Copyright © 2008, National Collaborating Centre for Women’s and Children’s Health.

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