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National Collaborating Centre for Chronic Conditions (UK). Chronic Kidney Disease: National Clinical Guideline for Early Identification and Management in Adults in Primary and Secondary Care. London: Royal College of Physicians (UK); 2008 Sep. (NICE Clinical Guidelines, No. 73.)
This publication is provided for historical reference only and the information may be out of date.
Chronic Kidney Disease: National Clinical Guideline for Early Identification and Management in Adults in Primary and Secondary Care.
Show detailsAcronyms and abbreviations
- AASK
African American Study of Kidney Diseases and Hypertension
- ABLE
A Better Life through Education and Empowerment
- ACEI
- ACR
Albumin:creatinine ratio
- ACS
Acute coronary syndrome
- ADPKD
Autosomal dominant polycystic kidney disease
- ALP
Alkaline phosphatase
- ARB
Angiotensin receptor blocker
- ARIC
Atherosclerosis Risk in Communities
- BMD
Bone mineral density
- BMI
Body mass index
- BNF
British National Formulary
- BP
Blood pressure
- CABG
Coronary artery bypass grafting
- CAD
Coronary artery disease
- CARI
Caring for Australasians with Renal Impairment
- CHS
Cardiovascular Health Studies
- CRF
Chronic renal failure
- CRI
Chronic renal insufficiency
- CURE
Clopidogrel in Unstable Angina to Prevent Recurrent Events
- CI
- CKD
Chronic kidney disease
- CrCl
Creatinine clearance
- CV
Coefficient of variation
- CVD
Cardiovascular disease
- DBP
Diastolic blood pressure
- DMP
Disease management programme
- DNCSG
Diabetic Nephropathy Collaborative Study Group
- eGFR
Estimated glomerular filtration rate
- ESRD
End stage renal disease
- GDG
- GFR
Glomerular filtration rate
- HDL
High-density lipoprotein
- ICER
Incremental cost-effectiveness ratio
- KEEP
Kidney Early Evaluation Program
- HF
Heart failure
- HR
- HYP
Hypertension
- IDMS
Isotope dilution mass spectrometry
- IDNT
Irbesartan in Diabetic Nephropathy Trial
- IgA-GN
Immunoglobulin-A glomerulonephritis
- iPTH
Intact parathyroid hormone
- KDIGO
Kidney Disease Improving Global Outcomes
- KDOQI
Kidney Disease Outcomes Quality Initiative
- LDL
Low density lipoprotein
- LDL-C
Low density lipoprotein cholesterol
- LPD
Low protein diet
- LVEF
Left ventricular ejection fraction
- MAP
Mean arterial pressure
- MDRD
Modification of Diet in Renal Disease
- MI
Myocardial infarction
- NCC-CC
National Collaborating Centre for Chronic Conditions
- NEOERICA
New Opportunities for Early Renal Intervention by Computerised Assessment
- NHANES
National Health and Nutrition Examination Surveys
- NHS
- NICE
National Institute for Health and Clinical Excellence
- NKF-KDOQI
National Kidney Foundation Kidney Disease Outcomes Quality Initiative
- NNS
Number needed to screen
- NNT
Number needed to treat
- NS
Non-significant
- NSAIDs
Non-steroidal anti-inflammatory drugs
- NSF
National service framework
- NSTEACS
Non-ST-segment elevation acute coronary syndrome
- OR
- PCR
Protein:creatinine ratio
- PREVEND
Prevention of Renal and Vascular Endstage Disease
- PTH
Parathyroid hormone
- pmp
Per million population
- QOF
Quality and Outcomes Framework
- QALY
- RBC
Red blood cells
- RCT
- REIN RCT
Ramipril Efficacy in Nephropathy RCT
- RENAAL
Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan study
- ROC
Receiver-operator curve
- RR
- RRT
Renal replacement therapy
- SBP
Systolic blood pressure
- SCr
- SHARP
Study of Heart and Renal Protection
- SIGN
Scottish Intercollegiate Guidelines Network
- SLT
Systemic lupus erythematosus
- STEACS
ST-segment elevation acute coronary syndrome
- UKPDS
UK Prospective Diabetes Study
- UPD
Usual protein diet
- WMD
Weighted mean difference
Glossary
- Angiotensin-converting enzyme inhibitor
A drug that inhibits ACE (angiotensin-converting enzyme) which is important to the formation of angiotensin II. ACE inhibitors are used for blood pressure control and congestive heart failure.
- Adverse events
A harmful, and usually relatively rare, event arising from treatment.
- Albuminuria
The presence of albumin in the urine.
- Algorithm (in guidelines)
A flow chart of the clinical decision pathway described in the guideline.
- Allocation concealment
The process used to prevent advance knowledge of group assignment in an RCT.
- Audit
See ‘Clinical audit’.
- Before and after study
See ‘Observational study’.
- Bias
The effect that the results of a study are not an accurate reflection of any trends in the wider population. This may result from flaws in the design of a study or in the analysis of results.
- Blinding (masking)
A feature of study design to keep the participants, researchers and outcome assessors unaware of the interventions which have been allocated.
- Carer (care giver)
Someone other than a health professional who is involved in caring for a person with a medical condition, such as a relative or spouse.
- Case-control study
Comparative observational study in which the investigator selects individuals who have experienced an event (for example, developed a disease) and others who have not (controls), and then collects data to determine previous exposure to a possible cause.
- Clinical audit
A quality improvement process that seeks to improve patient care and outcomes through systematic review of care against explicit criteria and the implementation of change.
- Clinician
In this guideline, the term clinician means any health care professional.
- Cochrane review
A systematic review of the evidence from randomised controlled trials relating to a particular health problem or healthcare intervention, produced by the Cochrane Collaboration. Available electronically as part of the Cochrane Library.
- Cohort study
A retrospective or prospective follow-up study. Groups of individuals to be followed up are defined on the basis of presence or absence of exposure to a suspected risk factor or intervention. A cohort study can be comparative, in which case two or more groups are selected on the basis of differences in their exposure to the agent of interest.
- Confidence interval (CI)
A range of values which contains the true value for the population with a stated ‘confidence’ (conventionally 95%). The interval is calculated from sample data, and generally straddles the sample estimate. The 95% confidence value means that if the study, and the method used to calculate the interval, is repeated many times, then 95% of the calculated intervals will actually contain the true value for the whole population.
- Cost-effectiveness analysis
An economics study design in which consequences of different interventions are measured using a single outcome, usually in natural units (for example, life-years gained, deaths avoided, heart attacks avoided, cases detected). Alternative interventions are then compared in terms of cost per unit of effectiveness.
- Cost-effectiveness model
An explicit mathematical framework, which is used to represent clinical decision problems and incorporate evidence from a variety of sources in order to estimate the costs and health outcomes.
- Cost-utility analysis
A form of cost-effectiveness analysis in which the units of effectiveness are quality-adjusted life-years (QALYs).
- Diagnostic study
Any research study aimed at evaluating the utility of a diagnostic procedure.
- Evidence-based healthcare
The process of systematically finding, appraising, and using research findings as the basis for clinical decisions.
- Follow up
An attempt to measure the outcomes of an intervention after the intervention has ended.
- Generalisability
The degree to which the results of a study or systematic review can be extrapolated to other circumstances, particularly routine health care situations in the NHS in England and Wales.
- Gold standard
See ‘Reference standard’.
- Guideline development group (GDG)
An independent group set up on behalf of NICE to develop a guideline. They include healthcare professionals and patient and carer representatives.
- Hazard ratio (HR)
A statistic to describe the relative risk of complications due to treatment, based on a comparison of event rates.
- Haematuria
The presence of blood in the urine; often a symptom of urinary tract disease.
- Heterogeneity
In systematic reviews, heterogeneity refers to variability or differences between studies in estimates of effect.
- Homogeneity
In a systematic review, homogeneity means there are no or minor variations in the results between individual studies included in a systematic review.
- Hyperkalaemia
Abnormally high potassium concentration in the blood, most often due to defective renal excretion, as in kidney disease.
- Inclusion criteria
Explicit criteria used to decide which studies should be considered as potential sources of evidence.
- Incremental cost
The cost of one alternative less the cost of another.
- Incremental cost effectiveness ratio (ICER)
The ratio of the difference in costs between two alternatives to the difference in effectiveness between the same two alternatives.
- Level of evidence
A code (e.g. 1++, 1+, 2++) linked to an individual study, indicating where it fits into the NICE hierarchy of evidence and how well it has adhered to recognised research principles.
- Macroalbuminuria
Albuminuria characterised by an ACR ≥30 mg/mmol.
- Meta-analysis
A statistical technique for combining (pooling) the results of a number of studies that address the same question and report on the same outcomes to produce a summary result.
- Methodological limitations
Features of the design or reporting of a clinical study, which are known to be associated with risk of bias or lack of validity. Where a study is reported in this guideline as having significant methodological limitations, a recommendation has not been directly derived from it.
- Microalbuminuria
Albuminuria characterised by an ACR 2.5–30 mg/mmol in men and 3.5–30 mg/mmol in women.
- Multivariate model
A statistical model for analysis of the relationship between two or more predictor (independent) and the outcome (dependent) variable.
- National Collaborating Centre for Chronic Conditions (NCC-CC)
A partnership of the Clinical Effectiveness Forum for Allied Health Professions, the NHS Confederation, the NICE Patient & Public Involvement Programme, the Royal College of General Practitioners, the Royal College of Nursing, the Royal College of Physicians of London, the Royal College of Physicians’ Patient Involvement Unit, the Royal College of Surgeons of England, and the Royal Pharmaceutical Society of Great Britain. Set up in 2001 to undertake commissions from NICE to develop clinical guidelines for the NHS.
- National Health Service (NHS)
This guideline is written for the NHS in England and Wales.
- National Institute for Health and Clinical Excellence (NICE)
NICE is the independent organisation responsible for providing national guidance on the promotion of good health and the prevention and treatment of ill health.
- Negative predictive value
The proportion of people with a negative test result who do not have the disease.
- Observational study
Retrospective or prospective study in which the investigator observes the natural course of events with or without control groups, for example cohort studies and case-control studies.
- Odds ratio
A measure of treatment effectiveness. The odds of an event happening in the intervention group, divided by the odds of it happening in the control group. The ‘odds’ is the ratio of non-events to events.
- Outcome
Measure of the possible results that may stem from exposure to prevention or therapeutic intervention. Outcome measures may be intermediate endpoints or they can be final endpoints.
- p values
The probability that an observed difference could have occurred by chance. A p value of less than 0.05 is conventionally considered to be ‘statistically significant’.
- Placebo
An inactive and physically indistinguishable substitute for a medication or procedure, used as a comparator in controlled clinical trials.
- Positive predictive value (PPV)
The proportion of people with a positive test result who actually have the disease.
- Proteinuria
The presence of protein in the urine.
- Pure red cell aplasia (PRCA)
Transitory arrest of erythropoiesis.
- Quality of life
Refers to the level of comfort, enjoyment, and ability to pursue daily activities.
- Quality-adjusted life year (QALY)
A measure of health outcome which assigns to each period of time a weight, ranging from 0 to 1, corresponding to the health-related quality of life during that period, where a weight of 1 corresponds to optimal health, and a weight of 0 corresponds to a health state judged equivalent to death; these are then aggregated across time periods.
- Randomisation
Allocation of participants in a study to two or more alternative groups using a chance procedure, such as computer-generated random numbers. This approach is used in an attempt to reduce sources of bias.
- Randomised controlled trial (RCT)
A comparative study in which participants are randomly allocated to intervention and control groups and followed up to examine differences in outcomes between the groups.
- Reference standard (or gold standard)
An agreed desirable standard, for example a diagnostic test or treatment, against which other interventions can be compared.
- Relative risk (RR)
An estimate for the number of times more likely or less likely an event is to happen in one group of people compared with another, based on the incidence of the event in the intervention arm of a study, divided by the incidence in the control arm.
- Sample size
The number of participants included in a trial or intervention group.
- Sensitivity (of a test)
The proportion of people classified as positive by the gold standard, who are correctly identified by the study test.
- Sensitivity analysis
A measure of the extent to which small changes in parameters and variables affect a result calculated from them. In this guideline, sensitivity analysis is used in health economics modelling.
- Serum creatinine
An endogenous marker used to estimate kidney function. Creatinine is derived from the muscles of the body and is normally removed from blood by the kidneys. As kidney disease progresses, the level of creatinine in the blood increases.
- Single blind study
A study where the investigator is aware of the treatment or intervention the participant is being given, but the participant is unaware.
- Specialist
A clinician whose practice is limited to a particular branch of medicine or surgery, especially one who is certified by a higher medical educational organisation.
- Specificity (of a test)
The proportion of people classified as negative by the gold standard, who are correctly identified by the study test.
- Stakeholder
Any national organisation, including patient and carers’ groups, healthcare professionals and commercial companies with an interest in the guideline under development.
- Statistical power
In clinical trials, the probability of correctly detecting an underlying difference of a pre-specified size due to the intervention or treatment under consideration. Power is determined by the study design, and in particular, the sample size. Larger sample sizes increase the chance of small effects being correctly detected as statistically significant, though they may not be clinically significant.
- Statistical significance
A result is deemed statistically significant if the probability of the result occurring by chance is less than 1 in 20 (p <0.05).
- Suffix ‘(p)’
Used to denote the presence of proteinuria when staging CKD.
- Systematic review
Research that summarises the evidence on a clearly formulated question according to a pre-defined protocol using systematic and explicit methods to identify, select and appraise relevant studies, and to extract, collate and report their findings. It may or may not use statistical meta-analysis.
- Washout period
The stage in a crossover trial when one treatment is withdrawn before the second treatment is given.
- Withdrawal
When a trial participant discontinues the assigned intervention before completion of the study.
- Acronyms, abbreviations and glossary - Chronic Kidney DiseaseAcronyms, abbreviations and glossary - Chronic Kidney Disease
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