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Auto-brewery Syndrome (Gut Fermentation)

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Last Update: October 9, 2019.

Introduction

Auto-brewery syndrome or gut fermentation syndrome is a condition in which ethanol is produced through endogenous fermentation by fungi or bacteria in the gastrointestinal (GI) system. Patients with auto-brewery syndrome present with many of the signs and symptoms of alcohol intoxication while denying an intake of alcohol and often report a high-sugar, high-carbohydrate diet.

The production of endogenous ethanol occurs in minute quantities as part of normal digestion, but when fermenting yeast or bacteria become pathogenic, extreme blood alcohol levels may result. Auto-brewery syndrome is more prevalent in patients with co-morbidities such as diabetes, obesity, and Crohn disease [1][2] but can occur in otherwise healthy individuals.[3] Several strains of fermenting yeasts and rare bacteria are identified as the pathogens. While auto-brewery syndrome is rarely diagnosed, it is probably underdiagnosed.[4]

Etiology

Various yeasts from the Candida and Saccharomyces families are commensals turned pathogenic that cause auto-brewery syndrome. Two strains of bacteria are also known to ferment ethanol.

  • Fermenting yeasts such as Saccharomyces cerevisiae, S. boulardii, and various strains of Candida, including C. glabrata, C. albicans, C. kefyr, and C. parapsilosis are identified as causes of this condition. The bacteria Klebsiella pneumonia and Enterococcus faecium were implicated in at least one case.[2][4][5][6][7][8]
  • Existing conditions, such as diabetes or liver problems, can impact the diagnosis of ABS. Patients with type 2 diabetes mellitus (DM) or liver cirrhosis (LC) tested higher for endogenous ethanol (EnEth) levels than a control group without the disease. But the EnEth levels peaked highest in a group of patients with both type 2 DM and LC, where the blood alcohol concentration reached 22.3 mg/dL.[1][9][1]
  • Four common yeasts (Candida albicansCandida tropicalisSaccharomyces cerevisiae, and Torulopsis glabrata) were combined with infant formulas. Ethanol production was measured after 24 and 48 hours. The quantities of ethanol produced suggest an explanation for patients exhibiting auto-brewery syndrome.[10]
  • Bacterial production of EnEth is involved in the development of non-alcoholic fatty liver disease (NAFLD). Higher levels of EnEth are also detected in obese patients and those with non-alcoholic steatohepatitis (NASH).[11][12][13][14]

Epidemiology

Auto-brewery syndrome is a rare condition. The disease has been identified in both male and female adults and children in many countries and is likely underdiagnosed.

Pathophysiology

A perturbation of the gut microbiome is the underlying condition that allows fermenting microbes to over-colonize. Such gut disturbances are caused by a diet high in carbohydrates and refined foods and the overuse of antibiotic and non-antibiotic drugs in food and medicine.[15][16]

Other underlying conditions may contribute to the pathogenesis of auto-brewery syndrome:

  • Auto-brewery syndrome occurred in several patients with short bowel syndrome, pseudoobstruction, or small intestinal bacterial overgrowth (SIBO) who exhibited signs and symptoms of alcohol intoxication.[5][6][7][8]
  • Patients with auto-brewery syndrome (ABS) (N=28; 16 male and 12 female) were compared to an asymptomatic group (N=18) regarding lifestyle and health, diet, and medical history. The data show significant differences between the groups. The ABS group reported poorer overall health and more food sensitivities. They consume more water, less tea, coffee, dairy, and candy; they eat out less, cook more at home, and have more aversion to starch. The ABS members also report bad breath, diarrhea, and bowel changes. Most importantly, patients with auto-brewery syndrome report using antibiotics for a longer time. While not statistically significant, the people in the ABS group also report more diagnosed GI disorders.[3]
  • Measurements of endogenous ethanol have been made, and in rare instances, a high ethanol concentration of greater than 400 mg/dL was identified. In these individuals, endogenous ethanol appears after the consumption of a high carbohydrate diet. Stress and skipping meals may also exacerbate these high ethanol levels.[4]
  • A genetic polymorphism that results in reduced activity of aldehyde dehydrogenases enzymes involved in the hepatic metabolism of ethanol and a first-pass metabolism might explain the ethnic differences in rates of endogenous ethanol production and clearance.[17] However, the enzymes have not been studied in auto-brewery syndrome patients specifically.

History and Physical

Auto-brewery syndrome has significant effects on a person’s life. The patient may experience side effects of vomiting, belching, chronic fatigue syndrome, dizziness, loss of coordination, disorientation, veisalgia, and irritable bowel symptoms. Chronic fatigue syndrome can result in health problems such as anxiety, depression, and poor productivity.

Because of the production of significant alcohol levels, people can test over the legal driving limit without consuming any alcohol. The randomness of intoxication episodes can result in difficulties for the patient, including injuries from falls, legal difficulties following driving citations, and strain on social relationships.

The obscurity of the condition challenges practitioners to diagnose and find a successful treatment. A comprehensive history and physical is essential, including a detailed diet history. Family members should supplement the intake history since patients may not remember their episodes of intoxication or what they ate prior to an episode.

Evaluation

Patients may not initially present with signs and symptoms of intoxication but may report neurological symptoms, loss of coordination, and mood changes. Auto-brewery syndrome should be considered in any patient presenting with an elevated blood alcohol level who denies ingestion of alcohol, including those arrested for DWI.[4]

Auto-brewery syndrome is more likely in a patient with chronic intestinal obstruction, gastroparesis, diabetes, or liver dysfunction such as non-alcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH). An interprofessional approach that includes a psychiatric evaluation should be employed. Auto-brewery syndrome should also be included in the differential diagnosis for D-lactic acidosis.[18]

Evaluation should include:

  • A complete history and physical; include history from family members regarding diet and alcohol intake and episodes of unexplained intoxication
  • Lab tests including CBC, metabolic panel, blood alcohol level, drug screen, and stool culture and sensitivity (bacterial and fungal)
  • Elimination of other primary causes such as head injury, secret drinking, psych diagnosis
  • Carbohydrate challenge of 200g glucose with BAC and BrAC testing at intervals of 0, 1/2, 1, 2, 4, 8, 16, and 24 hours; confirmation of auto-brewery syndrome if levels are elevated during the test.
  • Upper and lower endoscopy with samples for culture and sensitivity (bacterial and fungal).[4]

Treatment / Management

A coordinated treatment program should include patient input for compliance.

  • Immediate Care: The patient with an extremely high blood alcohol level should be treated for acute alcohol poisoning and stabilized.
  • Drug therapy: Prescribe drug therapy based on culture and sensitivity results for the identified yeast or bacteria. Most patients require a course of one or more of the azoles or polyenes. Rare or resistant microbes require an echinocandin or an antibiotic.
  • Diet therapy: An essential treatment of auto-brewery syndrome is diet modification requiring a high protein and low carbohydrates until symptoms subside. Sugar is fermented into alcohol, and a diet that eliminates simple and complex sugars will decrease the alcohol fermented from the gastrointestinal tract.
  • Supplements: Multistrain probiotic supplements help balance bacteria in the gastrointestinal tract and have been used in the treatment of auto-brewery syndrome but have yet to be studied as a treatment

The risk of relapse of auto-brewery syndrome is lessened by avoiding carbohydrates. A nutritionist should be involved in the treatment and management of the disease.

Anything that causes an imbalance between harmful and beneficial bacteria can potentially increase fermentation in the gut. Antibiotics should be avoided if possible. If a course of antibiotics is required, a plan should be in place to again test for fermenting pathogens and treat if necessary.

In single and various combinations, dietary carbohydrate control, antifungal or antibiotic therapy, general antibiotic avoidance, and probiotics have all been reported as successful treatments.

Differential Diagnosis

Rule out other possible causes such as head injury, psychiatric disorder, and hidden drinking.

Auto-brewery syndrome should be considered in the differential diagnosis of patients that are not consuming alcohol and yet exhibit the signs and symptoms of alcohol consumption; particularly if they are also consuming a high carbohydrate diet.

Prognosis

Some patients can resolve symptoms of auto-brewery syndrome by stopping antibiotics and following a sugar-free diet.[5] Others may require antifungals or antibiotics, along with diet modification. Probiotics, a low carbohydrate diet, and avoidance of antibiotics may help prevent relapse.

Complications

Auto-brewery syndrome is known to have a profound effect on patients and families. Most patients can resume a normal diet and lifestyle after one treatment. Other patients may relapse one or more times, especially if treated with antibiotics that disturb the gut microbiome.

In many cases, auto-brewery syndrome is mistaken for alcohol consumption, creating social and legal issues. Even after symptoms have resolved, the long-term exposure to endogenous ethanol can result in addiction to and cravings for alcohol with subsequent drinking.

Postoperative and Rehabilitation Care

Some combination of diet modification, drug therapy, and probiotics usually eliminates symptoms. Patients and healthcare providers should be aware of the possibility of relapse of symptoms. Occasionally a patient cultures an additional yeast that was resistant to the initial drug therapy. Some patients may also require an alcohol treatment program.

Consultations

Consult gastroenterology, infectious disease, and a registered nutritionist.

Deterrence and Patient Education

Patients should avoid sugars and carbohydrates and eat a diet higher in proteins during treatment. Long-term, patients should be educated on how to maintain a low carbohydrate diet, avoid dietary antibiotics, and abstain from drinking alcohol.

Patients should be taught about the microbiome and to avoid taking antibiotics unless necessary. If given antibiotics, they should ask their provider for a plan to prevent relapse.

Patients should be educated about the possibility of alcohol addiction after symptoms are resolved and be given referrals for alcohol treatment if needed.

Enhancing Healthcare Team Outcomes

Any patient with an elevated blood alcohol level who denies alcohol ingestion should be treated with empathy and compassion by all team members.

The diagnosis and management of auto-brewery syndrome (gut fermentation syndrome) are best done with an interprofessional team that includes a primary provider, a gastroenterologist, an infectious disease specialist, a nurse, and a nutritionist. An endocrinologist should be involved if the patient has diabetes and a hepatologist should be consulted in the event liver complications are detected. Pharmacists review medical treatments, check for drug-drug interactions, and provide patient education. Gastroenterology nurse specialists provide patient and family education, monitor patient progress, and report back to the team.

After diagnosis and stabilization, most patients can be treated as an outpatient. The main goal is to promote patient compliance with dietary changes, supplements, and if needed, medication. As symptoms subside, the healthcare team should assess alcohol cravings and make appropriate referrals.

Questions

To access free multiple choice questions on this topic, click here.

References

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Welch BT, Coelho Prabhu N, Walkoff L, Trenkner SW. Auto-brewery Syndrome in the Setting of Long-standing Crohn's Disease: A Case Report and Review of the Literature. J Crohns Colitis. 2016 Dec;10(12):1448-1450. [PubMed: 27161390]
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Jansson-Nettelbladt E, Meurling S, Petrini B, Sjölin J. Endogenous ethanol fermentation in a child with short bowel syndrome. Acta Paediatr. 2006 Apr;95(4):502-4. [PubMed: 16720504]
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Dahshan A, Donovan K. Auto-brewery syndrome in a child with short gut syndrome: case report and review of the literature. J. Pediatr. Gastroenterol. Nutr. 2001 Aug;33(2):214-5. [PubMed: 11568528]
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Bivin WS, Heinen BN. Production of ethanol from infant food formulas by common yeasts. J. Appl. Bacteriol. 1985 Apr;58(4):355-7. [PubMed: 3997687]
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Malik F, Wickremesinghe P, Saverimuttu J. Case report and literature review of auto-brewery syndrome: probably an underdiagnosed medical condition. BMJ Open Gastroenterol. 2019;6(1):e000325. [PMC free article: PMC6688673] [PubMed: 31423320]
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Spinucci G, Guidetti M, Lanzoni E, Pironi L. Endogenous ethanol production in a patient with chronic intestinal pseudo-obstruction and small intestinal bacterial overgrowth. Eur J Gastroenterol Hepatol. 2006 Jul;18(7):799-802. [PubMed: 16772842]
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Green AD, Antonson DL, Simonsen KA. Twelve-year-old female with short bowel syndrome presents with dizziness and confusion. Pediatr. Infect. Dis. J. 2012 Apr;31(4):425. [PubMed: 22418655]
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Aragonès G, González-García S, Aguilar C, Richart C, Auguet T. Gut Microbiota-Derived Mediators as Potential Markers in Nonalcoholic Fatty Liver Disease. Biomed Res Int. 2019;2019:8507583. [PMC free article: PMC6334327] [PubMed: 30719448]
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Nair S, Cope K, Risby TH, Diehl AM, Terence RH. Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis. Am. J. Gastroenterol. 2001 Apr;96(4):1200-4. [PubMed: 11316170]
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Cordell BJ, Kanodia A, Miller GK. Case-Control Research Study of Auto-Brewery Syndrome. Glob Adv Health Med. 2019;8:2164956119837566. [PMC free article: PMC6475837] [PubMed: 31037230]
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Bookshelf ID: NBK513346PMID: 30020718

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