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National Research Council (US) Committee on Scientific Milestones for the Development of a Gene Sequence-Based Classification System for the Oversight of Select Agents. Sequence-Based Classification of Select Agents: A Brighter Line. Washington (DC): National Academies Press (US); 2010.

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Sequence-Based Classification of Select Agents: A Brighter Line.

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Appendix D2009 Workshop Agenda

Scientific Milestones for the Development of a Gene-Sequence-Based Classification System for Oversight of Select Agents

Thursday, Sept. 3rd, 2009

The National Academy of Sciences Building: Lecture Room

2100 C St., N.W. • Washington, D.C. 20037


8:30 a.m.Welcome and Opening Remarks
James LeDuc, committee chair—The University of Texas Medical School
The workshop in context of the study and the statement of task
9:00 a.m.Session 1: The Current Structure for Oversight
What are the current forms of oversight? Are there gaps in the oversight, and if so, are these gaps emerging as a result of new technology, new user communities, or new perceptions? How might a sequence based system be helpful in addressing these gaps/concerns?
 *Moderator: Rachel Levinson
  • Julia Kiehlbauch, United States Department of Agriculture, Animal and Plant Health Inspection Service
  • Rob Weyant, Centers for Disease Control and Prevention—Synthetic DNA and the Select Agent Regulations.
  • Claudia Mickelson, Massachusetts Institute of Technology—IBC, RAC guidelines and concerns about sequences.
  • Edward You, Federal Bureau of Investigation— Surveillance of Select Agent list and emerging concerns.
  • Amy Patterson, National Institutes of Health, Office of Biotechnology Activities—Comprehensive view and the need for this study.
Panel discussion: ~30 min
10:30 a.m.Break
10:45 a.m.Session 2: Current Mechanisms and Criteria for Screening and Surveillance
What is currently being done? How are sequences chosen to monitor? What is a “sequence of concern”?
 *Moderator—John Mulligan
  • Pete Pesenti, Department of Homeland Security—What are the factors and process used for risk assessment? What are the criteria or characteristics of agents (or sequences) considered a threat?
  • John Mulligan, Blue Heron Biotechnology—What are the current screening practices, standards, and procedures in the industry? What are challenges and concerns?
  • Marcus Graf, GeneArt and Claes Gustafsson, DNA 2.0—Representing companies working to harmonize screening techniques. What would they like to know to help the decision making process?
  • Stephen M. Maurer, University of California at Berkeley—Interface of biosecurity, synthetic biology, and industry.
Panel discussion: ~30 min ** Ed You, FBI will join panel **
12:15 p.m.Lunch
1:00 p.m.Session 3: Virulence
What is virulence? Why is it so hard to predict? What attributes make a pathogen a threat to biosecurity? —to public health? Is there a difference?
 *Moderator—Stan Falkow
  • Stan Falkow, Stanford University—Overview of virulence, meaning of genomics in prediction.
  • Jeff Taubenberger, National Institutes of Health, National Institute of Allergy and Infectious Diseases— Influenza virulence and the role of genotype-phenotype relationships.
  • Michael Katze, University of Washington—Systems biology and the difficulty predicting the importance of a sequence.
  • Ralph Baric, University of North Carolina at Chapel Hill—SARS, systems genetics and pathogenesis.
  • Ramon Felciano, Ingenuity Systems—Systems biology and pathway modeling of pathogenesis and host response.
Panel discussion: ~30 min
3:10 p.m.Break
3:25 p.m.Session 4: Predicting Pathogenicity from Sequence
Speakers will address gaps, challenges, and timeframe for milestones.
 *Moderator—Sean Eddy
  • Sean Eddy, Howard Hughes Medical Institute, Janelia Farm Research Campus—Overview of sequence analysis; how reliably can protein function be predicted from protein sequence?
  • Jonathon Eisen, University of California at Davis— Phylogenomic inference of protein function and the importance of genomic context.
  • Elliot J Lefkowitz, University of Alabama at Birmingham—Bioinformatics support for pathogen research; Viral gene discovery and pathogenic potential.
  • John Moult, University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology—Protein structure and function prediction.
  • Ian Lipkin, Columbia University, Mailman School of Public Health—Identification of emerging or novel microorganisms—pathogen surveillance.
Panel discussion: ~30 min
5:45 p.m.Closing Remarks
6:00 p.m.Adjourn
Copyright © 2010, National Academy of Sciences.
Bookshelf ID: NBK50877


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