Table 5SAR of Quinazoline series

#CIDSID*
Image ml143fu8.jpg
CPE IC50 (μM)Cytotox TC50 (μM)SI**
nR4R5R6R7R8R9
14371333887219061P1HOHHBrHH>2535.5<1.42
1592827787219062S1HHHBrHH16.819711.7
16304629085176845P1HHHHHH>80>801
174453768987218710S2HOHHBrHH>200>2001
184453769387218716S3HOHHBrHH>20037.64<0.20
194453769187218713S2HOHFHHH>200>2001
204453769087218712S1HOHHClHCl>200>2001
214453769487218717S3HOHFHHH>200>2001
224425147685285658S1HOHHNO2HH>40>401
234425147885285662S1CH3OHHBrHH>40>401
*

P= purchased S = synthesized

**

SI = selectivity index = TC50/IC50

From: A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activity Against West Nile Virus

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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