Table 4Structure and activity of analogs of 5

Image ml133fu24.jpg
CmpdCIDSIDVU#*RKir2.1 IC50 (nM) – Manual Patch ClampKir2.1 IC50 (nM) – Ion Works
3a4424746685281105VU0404943-1S
Image ml133fu25.jpg
29013630
5a4454349087225317VU0409040-1S
Image ml133fu26.jpg
23620
5b4454349287225318VU0409041-1S
Image ml133fu27.jpg
18080
5c82977987225311VU0409034-1S
Image ml133fu28.jpg
22970
5d87211387225314VU0409037-1S
Image ml133fu29.jpg
38490
5e87132687225310VU0409033-1S
Image ml133fu30.jpg
37880
5f77545287225309VU0409032-1S
Image ml133fu31.jpg
28160
5g78130387225312VU0409035-1S
Image ml133fu32.jpg
37280
5h4454350187225325VU0409048-1S
Image ml133fu33.jpg
no fit
5i4454348887225316VU0409039-1S
Image ml133fu34.jpg
46270
5j4454349587225321VU0409044-1S
Image ml133fu35.jpg
no fit
5k4454349887225323VU0409046-1S
Image ml133fu36.jpg
no fit
5l4454350087225324VU0409047-1S
Image ml133fu37.jpg
101940
5m4454349687225322VU0409045-1S
Image ml133fu38.jpg
199300
5n4454350587225327VU0409050-1S
Image ml133fu39.jpg
no fit
5o4454350387225326VU0409049-1S
Image ml133fu40.jpg
161890
5p4454349387225319VU0409042-1S
Image ml133fu41.jpg
40330
5q4454349487225320VU0409043-1S
Image ml133fu42.jpg
37160
5r4454348787225315VU0409038-1S
Image ml133fu43.jpg
no fit

From: A potent and selective small molecule Kir2.1 inhibitor

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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