Comparative Evidence for 2DRT, 3DCRT, and IMRT
Tumor Control or Survival: There is insufficient evidence to determine if 2DRT, 3DCRT, or IMRT confers any advantages when compared to each other in terms of tumor control or survival.
Adverse Effects: IMRT is associated with a lower incidence of late xerostomia when compared to 3DCRT (Image clinheadfu2.jpg) or 2DRT (Image clinheadfu2.jpg). There is insufficient evidence to permit conclusions about the comparative effects of 2DRT, 3DCRT, or IMRT on adverse events other than late xerostomia.
Quality of Life: Patients who received IMRT had improved quality of life, with respect to late xerostomia, when compared with those who received 3DCRT (Image clinheadfu2.jpg) or 2DRT (Image clinheadfu2.jpg). There is insufficient evidence to determine the comparative effects of IMRT, 3DCRT, and 2DRT on other quality-of-life measures.
Experience of Treatment Team: The data is insufficient to determine whether the experience of the clinical team confers an advantage, because no comparative studies addressed this issue.
Comparative Evidence for Proton Beam Therapy vs. 2DRT, 3DCRT, and IMRT
Across Outcomes: No comparative studies addressed the domains of tumor control, survival, adverse effects, quality of life, or experience of the treatment team. Therefore, the data are insufficient to permit any conclusions about proton beam therapy when compared to other radiotherapy modalities for head and neck cancer.

From: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer

Cover of Comparative Effectiveness Review Summary Guides for Clinicians
Comparative Effectiveness Review Summary Guides for Clinicians [Internet].

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.