Table 15Clozapine compared with olanzapine: Adverse events

StudyAtypical antipsychotic (mg daily)HypersalivationDizzinessSomnolence
Atmaca 2003Clozapine 207.1Not reportedNot reportedNot reported
Olanzapine 15.7Not reportedNot reportedNot reported
Volavka 2002Clozapine 500–526.6Not reportedNot reportedNot reported
Olanzapine 20–30.4Not reportedNot reportedNot reported
Bitter 2004Clozapine 2165/74 (6.8%)6/74 (8.1%)11/74 (14.9%)
Olanzapine 171/76 (1.3%)1/76 (1.3%)2/76 (2.6%)
Tollefson 2001Clozapine 30326/90 (28.9)8/90 (8.9%)22/90 (24.4%)
Olanzapine 212/90 (2.2)1/90 (1.1%)12/90 (13.3%)
Pooled risk difference (95% CI)0.16 (0.09 to 0.42) NNH = 60.08 (0.03 to 0.12) NNH = 130.12 (0.05 to 0.19) NNH = 8
InterSePT Meltzer 2003Risk difference (95% CI)0.42 (0.37 to 0.47) NNH = 20.15 (0.10 to 0.20) NNH = 70.21 (0.15 to 0.27) NNH = 5

Abbreviations: NNH, number needed to harm.

From: Results

Cover of Drug Class Review: Atypical Antipsychotic Drugs
Drug Class Review: Atypical Antipsychotic Drugs: Final Update 3 Report [Internet].
McDonagh M, Peterson K, Carson S, et al.
Portland (OR): Oregon Health & Science University; 2010 Jul.
Copyright © 2010 by Oregon Health & Science University, Portland, Oregon 97239. All rights reserved.

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