Original Report and Update 1

AuthorAgentsCharacteristics
Placebo-controlled trials
Bernstein 1997Fexofenadine 60, 120, 240 mg bidSAR, mc, r db, pc, 57 pts late summer 2 wks
Casale 1999Fexofenadine 120 or 180 mg qdSAR mc, r, pc, 861 pts. 2 wks
Ciprandi 2001Fexofenadine 120 180mgPAR, db, pc, 31 pts 4 wks
Dolovich 1994Loratadine 10 mg qdSAR, db, pc, 180 pts 6 weeks
Juhlin 1991Cetirizine 10 or 20 mg qdCIU, db, pc, 30 pts 2 wks
Juhlin 1988Cetirizine 10 mg qdCIU, r, db, pc, 30 pts 2 wks
Mansmann 1991Cetirizine 10, 20 mg qdPAR, db, pc, 215 pts 4 wk
Meltzer 1999Fexofenadine 120 or 180 mg qdSAR, r, db, pc, QoL
Monroe 2003Desloratadine 5mg qdCIU, r, db, pc, 6 wk
Monroe 1998Loratadine 10 mg qdCIU, mc, db, pc, 169 pts. 4 wks
Murray 2002CetirizineSAR mc, r, db, pc, , 865 pts. 2 wks
Nelson 2000Fexofenadine 20, 60, 120, or 240mgCIU, r, db, pc, 4 wks
Raptopoulou 1993Loratadine 10 mgSAR, db, pc, 48 pts. 4 wks
Salmun 2002Desloratadine 2.5, 5, 7.5, 10, or 20 mg qdSAR, r, db, pc, 1026 pts 2 wks
Thompson 2000Fexofenadine 60 mg twice dailyCUI mc, r db, pc 160 & 165 pt trials 4 wks
Vena 2002Fexofenadine 180 mg qdCIU, open, 20 pts. 4 wks.
Wasserman 1991Cetirizine 10 mg and 5mg qdSAR, db, pc, 88 pts spring 2 wks
Zuberbier 1995Cetirizine 10 or 20 mg qdCIU, r, db, 24 pts 3wks
Zuberbier 1996Cetirizine 20 mg qdCIU, db, pc, 11 pts. 3 wks

Abbreviations: bid, twice daily; CIU, chronic idiopathic urticaria; db, double blind; PAR, perennial allergic rhinitis; pts, patients; qd, once daily; QoL, quality-of-life; mc, SAR, seasonal allergic rhinitis; tid; 3 times daily; wks, weeks.

From: Appendix F, Poor-quality studies

Cover of Drug Class Review: Newer Antihistamines
Drug Class Review: Newer Antihistamines: Final Report Update 2 [Internet].
Carson S, Lee N, Thakurta S.
Portland (OR): Oregon Health & Science University; 2010 May.
Copyright © 2010 by Oregon Health & Science University, Portland, Oregon 97239. All rights reserved.

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