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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Dorzolamide

Last Revision: April 20, 2020.

Estimated reading time: 1 minute

CASRN: 120279-96-1

image 135049468 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Limited experience with the use of ophthalmic dorzolamide indicate that it is unlikely to adversely affect the breastfed infant.[1] To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

A newborn infant was breastfed during maternal therapy with ocular timolol, dipivifrin, dorzolamide, brimonidine and several doses of acetazolamide. The drugs were given immediately following breastfeeding and no apnea or bradycardia was observed in the infant.[2]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Belkin A, Chen T, DeOliveria AR, et al. A practical guide to the pregnant and breastfeeding patient with glaucoma Ophthalmol Glaucoma 2020;3:79-89. doi:10.1016/j.ogla.2019.12.004. [CrossRef]
2.
Johnson SM, Martinez M, Freedman S. Management of glaucoma in pregnancy and lactation. Surv Ophthalmol. 2001;45:449–54. [PubMed: 11274697]

Substance Identification

Substance Name

Dorzolamide

CAS Registry Number

120279-96-1

Drug Class

Breast Feeding

Lactation

Antiglaucoma Agents

Carbonic Anhydrase Inhibitors

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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