NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

Cover of Drugs and Lactation Database (LactMed)

Drugs and Lactation Database (LactMed) [Internet].

Show details

Diltiazem

Last Revision: October 31, 2018.

Estimated reading time: 1 minute

CASRN: 42399-41-7

Chemical structure

Drug Levels and Effects

Summary of Use during Lactation

Based on limited data, amounts of diltiazem ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.

Drug Levels

Maternal Levels. In one patient who was 14 days postpartum, peak milk levels of 190 to 230 mcg/L occurred about 2 hours after the dose during an oral regimen of 60 mg four times daily. The levels and time course of the drug in milk closely paralleled serum levels.[1] Using the peak milk level data from this patient, an exclusively breastfed infant would receive an estimated maximum of 0.9% of the maternal weight-adjusted dosage.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Nifedipine, Verapamil

References

1.
Okada M, Inoue H, Nakamura Y et al. Excretion of diltiazem in human milk. N Engl J Med. 1985;312:992-3. [PubMed: 3974691]

Substance Identification

Substance Name

Diltiazem

CAS Registry Number

42399-41-7

Drug Class

  • Breast Feeding
  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Antiarrhythmics
  • Vasodilator Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Views

Related information

Similar articles in PubMed

  • Review Nicardipine[Drugs and Lactation Database (...]
    Review Nicardipine
    . Drugs and Lactation Database (LactMed). 2006
  • Review Oxcarbazepine[Drugs and Lactation Database (...]
    Review Oxcarbazepine
    . Drugs and Lactation Database (LactMed). 2006
  • Review Imipramine[Drugs and Lactation Database (...]
    Review Imipramine
    . Drugs and Lactation Database (LactMed). 2006
  • Review Clomipramine[Drugs and Lactation Database (...]
    Review Clomipramine
    . Drugs and Lactation Database (LactMed). 2006
  • Review Nimodipine[Drugs and Lactation Database (...]
    Review Nimodipine
    . Drugs and Lactation Database (LactMed). 2006
See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...