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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 133454-47-4
Drug Levels and Effects
Summary of Use during Lactation
Because no information is available on the use of iloperidone during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Patients enlisted in the National Pregnancy Registry for Atypical Antipsychotics who were taking a second-generation antipsychotic drug while breastfeeding (n = 576) were compared to control breastfeeding patients who were not treated with a second-generation antipsychotic (n = 818). Of the patients who were taking a second-generation antipsychotic drug, 60.4% were on more than one psychotropic. A review of the pediatric medical records, no adverse effects were noted among infants exposed or not exposed to second-generation antipsychotic monotherapy or to polytherapy.[1] The number of women taking iloperidone was not reported.
Effects on Lactation and Breastmilk
Iloperidone causes minimal increases in serum prolactin.[2,3] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Patients enlisted in the National Pregnancy Registry for Atypical Antipsychotics who were taking a second-generation antipsychotic drug while breastfeeding (n = 576) were compared to control breastfeeding patients who had primarily diagnoses of major depressive disorder and anxiety disorders, most often treated with SSRI or SNRI antidepressants, but not with a second-generation antipsychotic (n = 818). Among women on a second-generation antipsychotic, 60.4% were on more than one psychotropic compared with 24.4% among women in the control group. Of the women on a second-generation antipsychotic, 59.3% reported “ever breastfeeding” compared to 88.2% of women in the control group. At 3 months postpartum, 23% of women on a second-generation antipsychotic were exclusively breastfeeding compared to 47% of women in the control group.[1] The number of women taking iloperidone was not reported.
Alternate Drugs to Consider
References
- 1.
- Viguera AC, Vanderkruik R, Gaccione P, et al. Breastfeeding practices among women taking second-generation antipsychotics: findings from the National Pregnancy Registry for Atypical Antipsychotics. Arch Womens Ment Health. 2022;25:511–6. [PubMed: 34318375]
- 2.
- Cutler AJ. Iloperidone: A new option for the treatment of schizophrenia. Expert Rev Neurother. 2009;9:1727–41. [PubMed: 19951132]
- 3.
- Weiden PJ, Cutler AJ, Polymeropoulos MH, et al. Safety profile of iloperidone: A pooled analysis of 6-week acute-phase pivotal trials. J Clin Psychopharmacol. 2008;28(2) Suppl 1:S12–9. [PubMed: 18334908]
Substance Identification
Substance Name
Iloperidone
CAS Registry Number
133454-47-4
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- Application of hyphenated LC/NMR and LC/MS techniques in rapid identification of in vitro and in vivo metabolites of iloperidone.[Drug Metab Dispos. 1995]Application of hyphenated LC/NMR and LC/MS techniques in rapid identification of in vitro and in vivo metabolites of iloperidone.Mutlib AE, Strupczewski JT, Chesson SM. Drug Metab Dispos. 1995 Sep; 23(9):951-64.
- Review Paliperidone.[Drugs and Lactation Database (...]Review Paliperidone.. Drugs and Lactation Database (LactMed®). 2006
- Application of liquid chromatography/mass spectrometry in accelerating the identification of human liver cytochrome P450 isoforms involved in the metabolism of iloperidone.[J Pharmacol Exp Ther. 1998]Application of liquid chromatography/mass spectrometry in accelerating the identification of human liver cytochrome P450 isoforms involved in the metabolism of iloperidone.Mutlib AE, Klein JT. J Pharmacol Exp Ther. 1998 Sep; 286(3):1285-93.
- Review Risperidone.[Drugs and Lactation Database (...]Review Risperidone.. Drugs and Lactation Database (LactMed®). 2006
- Ex vivo studies with iloperidone (HP 873), a potential atypical antipsychotic with dopamine D2/5-hydroxytryptamine2 receptor antagonist activity.[J Pharmacol Exp Ther. 1996]Ex vivo studies with iloperidone (HP 873), a potential atypical antipsychotic with dopamine D2/5-hydroxytryptamine2 receptor antagonist activity.Szczepanik AM, Brougham LR, Roehr JE, Conway PG, Ellis DB, Wilmot CA. J Pharmacol Exp Ther. 1996 Aug; 278(2):913-20.
- Iloperidone - Drugs and Lactation Database (LactMed®)Iloperidone - Drugs and Lactation Database (LactMed®)
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