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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.
CASRN: 124-43-6
Drug Levels and Effects
Summary of Use during Lactation
Carbamide (urea) peroxide has not been studied during breastfeeding. It is unlikely that carbamide peroxide found in ear drops or teeth whiteners is absorbed into the bloodstream. However, if any carbamide peroxide were absorbed, it would be broken down to urea and hydrogen peroxide, both of which are found normally in human milk.[1,2] If carbamide peroxide is used by the mother according to directions, it is not a reason to discontinue breastfeeding and no special precautions are required.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Clark RM, Ross SA, Hill DW, et al. Within-day variation of taurine and other nitrogen substances in human milk. J Dairy Sci. 1987;70:776–80. [PubMed: 3584613]
- 2.
- Al-Kerwi EA, Al-Hashimi AH, Salman AM. Mother's milk and hydrogen peroxide. Asia Pac J Clin Nutr. 2005;14:428–31. [PubMed: 16326651]
Substance Identification
Substance Name
Carbamide Peroxide
CAS Registry Number
124-43-6
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- A new three-component formulation for the efficient whitening of teeth (Carbamide Plus).[Clin Oral Investig. 2015]A new three-component formulation for the efficient whitening of teeth (Carbamide Plus).Hyland BW, McDonald A, Lewis N, Tredwin C, Petrie A, Hall S, Todd C, McCaughan B, Callan JF. Clin Oral Investig. 2015 Jul; 19(6):1395-404. Epub 2014 Nov 9.
- Oxidative stress aspects of the cytotoxicity of carbamide peroxide: in vitro studies.[Toxicol Lett. 1995]Oxidative stress aspects of the cytotoxicity of carbamide peroxide: in vitro studies.Sinensky MC, Leiser AL, Babich H. Toxicol Lett. 1995 Jan; 75(1-3):101-9.
- Effect of carbamide peroxide and hydrogen peroxide on the surface morphology and zinc oxide levels of IRM fillings.[Endod Dent Traumatol. 1995]Effect of carbamide peroxide and hydrogen peroxide on the surface morphology and zinc oxide levels of IRM fillings.Rostein I, Cohenca N, Mor C, Moshonov J, Stabholz A. Endod Dent Traumatol. 1995 Dec; 11(6):279-83.
- Review Biological properties of peroxide-containing tooth whiteners.[Food Chem Toxicol. 1996]Review Biological properties of peroxide-containing tooth whiteners.Li Y. Food Chem Toxicol. 1996 Sep; 34(9):887-904.
- Review Tooth bleaching--a critical review of the biological aspects.[Crit Rev Oral Biol Med. 2003]Review Tooth bleaching--a critical review of the biological aspects.Dahl JE, Pallesen U. Crit Rev Oral Biol Med. 2003; 14(4):292-304.
- Carbamide Peroxide - Drugs and Lactation Database (LactMed)Carbamide Peroxide - Drugs and Lactation Database (LactMed)
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