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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

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Drugs and Lactation Database (LactMed®) [Internet].

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Last Revision: December 20, 2021.

Estimated reading time: 1 minute

CASRN: 19216-56-9

image 134991798 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Because little is available on the use of prazosin during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. The manufacturer reports that one mother was studied and excreted at most 3% of the dose into her breastmilk. No study details were presented.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information in nursing mothers was not found as of the revision date. Prazosin does not affect serum prolactin concentration in patients with hypertension.[2,3] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


Schaefer C, Peters P, Miller RK eds. Drugs during pregnancy and lactation. Treatment options and risk assessment, 3rd ed. Boston: Academic Press. 2015:716. doi: 10.1016/B978-0-12-408078-2.00001-9. [CrossRef]
Barbieri C, Caldara R, Ferrari C, et al. Metabolic effects of prazosin. Clin Pharmacol Ther. 1980;27:313–6. [PubMed: 6102000]
Barbieri C, Ferrari C, Borzio M, et al. Metabolic effects of chronic prazosin treatment. Horm Metab Res. 1980;12:331–4. [PubMed: 6105121]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Adrenergic alpha-Antagonists

Antihypertensive Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Copyright Notice

Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK501644PMID: 30000705


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