Summary of Use during Lactation

Dronabinol is the synthetic form of delta-9-tetrahydrocannabinol, the major active component of cannabis. Delta-9-tetrahydrocannabinol is found in the breastmilk of mothers who use cannabis products.[1-3] Because no published information is available with dronabinol use as an antiemetic during breastfeeding, an alternate antiemetic should be used.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Meclizine, Metoclopramide, Prochlorperazine, Thiethylperazine

References

1.

Bertrand KA, Hanan NJ, Honerkamp-Smith G, et al. Marijuana use by breastfeeding mothers and cannabinoid concentrations in breast milk. Pediatrics. 2018;142:e20181076. [PMC free article: PMC6317767] [PubMed: 30150212]

2.

Baker T, Datta P, Rewers-Felkins K, et al. Transfer of inhaled cannabis into human breast milk. Obstet Gynecol. 2018;131:783–8. [PubMed: 29630019]

3.

Wymore EM, Palmer C, Wang GS, et al. Persistence of Δ-9-tetrahydrocannabinol in human breast milk. JAMA Pediatr. 2021;175:632–4. [PMC free article: PMC7941249] [PubMed: 33683306]

Substance Name

Dronabinol

CAS Registry Number

1972-08-3

Drug Class

Breast Feeding

Lactation

Milk, Human

Antiemetics

Cannabinoids