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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.
CASRN: 138530-94-6
Drug Levels and Effects
Summary of Use during Lactation
Dexlansoprazole is the R-enantiomer of the proton-pump inhibitor, lansoprazole. No information is available on the use of dexlansoprazole or lansoprazole during breastfeeding. However, lansoprazole has been used safely in newborn infants, so it is unlikely that the amount of dexlansoprazole in breastmilk would be harmful.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
A retrospective claims database study in the United States found that users of proton pump inhibitors had an increased risk of gynecomastia.[1]
One case of elevated serum prolactin and galactorrhea was reported in a 21-year-old man taking lansoprazole (the racemic form). When omeprazole was substituted for lansoprazole, the serum prolactin decreased to the normal range and galactorrhea ceased.[2]
Alternate Drugs to Consider
Antacids, Cimetidine, Famotidine, Omeprazole, Pantoprazole, Sucralfate
References
- 1.
- He B, Carleton B, Etminan M. Risk of gynecomastia with users of proton pump inhibitors. Pharmacotherapy. 2019;39:614–8. [PubMed: 30865318]
- 2.
- Izquierdo Prieto OM, Moreno Alia E, Rosillo González A. Aten Primaria. 2004;34:325–6. [Galactorrhea induced by lansoprazole] [PMC free article: PMC7668912] [PubMed: 15491529]
Substance Identification
Substance Name
Dexlansoprazole
CAS Registry Number
138530-94-6
- 1.
He B, Carleton B, Etminan M. Risk of gynecomastia with users of proton pump inhibitors. Pharmacotherapy 2019;39:614-8. PMID: 30865318
- 2.
Izquierdo Prieto OM, Moreno Alia E, Rosillo González A. [Galactorrhea induced by lansoprazole]. Aten Primaria 2004;34:325-6. PMID: 15491529
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review Lansoprazole[Drugs and Lactation Database (...]Review Lansoprazole. Drugs and Lactation Database (LactMed). 2006
- Drug interaction studies with dexlansoprazole modified release (TAK-390MR), a proton pump inhibitor with a dual delayed-release formulation: results of four randomized, double-blind, crossover, placebo-controlled, single-centre studies.[Clin Drug Investig. 2009]Drug interaction studies with dexlansoprazole modified release (TAK-390MR), a proton pump inhibitor with a dual delayed-release formulation: results of four randomized, double-blind, crossover, placebo-controlled, single-centre studies.Vakily M, Lee RD, Wu J, Gunawardhana L, Mulford D. Clin Drug Investig. 2009; 29(1):35-50.
- A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals.[J Pharmacol Exp Ther. 2011]A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals.Hori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M, Inatomi N. J Pharmacol Exp Ther. 2011 Jun; 337(3):797-804. Epub 2011 Mar 16.
- Review Pantoprazole[Drugs and Lactation Database (...]Review Pantoprazole. Drugs and Lactation Database (LactMed). 2006
- Dexlansoprazole for the treatment of esophagitis and GERD.[Drugs Today (Barc). 2010]Dexlansoprazole for the treatment of esophagitis and GERD.Davies SL. Drugs Today (Barc). 2010 Feb; 46(2):75-80.
- Dexlansoprazole - Drugs and Lactation Database (LactMed)Dexlansoprazole - Drugs and Lactation Database (LactMed)
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