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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Cephradine

Last Revision: October 31, 2018.

Estimated reading time: 1 minute

CASRN: 38821-53-3

Chemical structure

Drug Levels and Effects

Summary of Use during Lactation

Limited information indicates cephradine produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. cephradine is acceptable in nursing mothers.

Drug Levels

Maternal Levels. Six women were given cephradine 500 mg orally every 6 hours for 9 doses. Milk levels after the last dose were essentially constant for the 6 hours following the dose with a range of 0.62 to 0.68 mg/L.[1][2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Cephalexin

References

1.
Mischler TW, Corson SL, Bolognese RJ et al. Presence of cephradine in body fluids of lactating and pregnant women. Clin Pharmacol Ther. 1972;15:214. Abstract.
2.
Mischler TW, Corson SL, Larranaga A et al. Cephradine and epicillin in body fluids of lactating and pregnant women. J Reprod Med. 1978;21:130-6. [PubMed: 569206]

Substance Identification

Substance Name

Cephradine

CAS Registry Number

38821-53-3

Drug Class

  • Breast Feeding
  • Anti-Infective Agents
  • Antibacterial Agents
  • Cephalosporins

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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