Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 158966-92-8
Drug Levels and Effects
Summary of Use during Lactation
Very low levels of montelukast appear in breastmilk. Montelukast is approved for use in children as young as 6 months of age and has been used in neonates in dosages far greater than the amounts in breastmilk. Amounts ingested by the infant would not be expected to cause any adverse effects in breastfed infants. International guidelines consider that leukotriene receptor antagonists can be used during breastfeeding.[1,2]
Drug Levels
Maternal Levels. Seven women were given a 10 mg dose of montelukast and provide milk samples before the dose and at 6 times over the next 12 hours. Average peak milk concentration of the drug were 9.74 mcg/L at an average of 4 hours after the dose. The average milk concentration was 5.3 mcg/L which resulted in an average daily infant dosage of 0.79 mcg/kg (range 0.4 to 1.4 mcg/kg daily) or 0.68% of the weight-adjusted maternal dosage.[3]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Beclomethasone, Cromolyn, Terbutaline, Theophylline, Zafirlukast
References
- 1.
- Middleton PG, Gade EJ, Aguilera C, et al. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J 2020;55:1901208 [PubMed: 31699837]
- 2.
- Bendien SA, de Kruif MD, Feitsma H, et al. Summary of the Dutch Multidisciplinary Practice Guideline on Asthma and Pregnancy. J Allergy Clin Immunol Pract 2024;12:1751-62 [PubMed: 38513758]
- 3.
- Datta P, Rewers-Felkins K, Baker T, et al. Transfer of montelukast into human milk during lactation. Breastfeed Med 2017;12:54-7 [PubMed: 28002678]
Substance Identification
Substance Name
Montelukast
CAS Registry Number
158966-92-8
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- User and Medical Advice Disclaimer
- Drugs and Lactation Database (LactMed) - Record Format
- LactMed - Database Creation and Peer Review Process
- Fact Sheet. Drugs and Lactation Database (LactMed)
- Drugs and Lactation Database (LactMed) - Glossary
- LactMed Selected References
- Drugs and Lactation Database (LactMed) - About Dietary Supplements
- Breastfeeding Links
- PubChem SubstanceRelated PubChem Substances
- PubMedLinks to PubMed
- Review Sildenafil.[Drugs and Lactation Database (...]Review Sildenafil.. Drugs and Lactation Database (LactMed®). 2006
- Identification, synthesis, isolation and spectral characterization of potential impurities of montelukast sodium.[J Pharm Biomed Anal. 2008]Identification, synthesis, isolation and spectral characterization of potential impurities of montelukast sodium.Saravanan M, Siva Kumari K, Pratap Reddy P, Naidu MN, Moses Babu J, Srivastava AK, Lakshmi Kumar T, Chandra Sekhar BV, Satyanarayana B. J Pharm Biomed Anal. 2008 Nov 4; 48(3):708-15. Epub 2008 Jul 16.
- Review Olmesartan.[Drugs and Lactation Database (...]Review Olmesartan.. Drugs and Lactation Database (LactMed®). 2006
- Review Anidulafungin.[Drugs and Lactation Database (...]Review Anidulafungin.. Drugs and Lactation Database (LactMed®). 2006
- Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist.[Can J Physiol Pharmacol. 1995]Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist.Jones TR, Labelle M, Belley M, Champion E, Charette L, Evans J, Ford-Hutchinson AW, Gauthier JY, Lord A, Masson P. Can J Physiol Pharmacol. 1995 Feb; 73(2):191-201.
- Montelukast - Drugs and Lactation Database (LactMed®)Montelukast - Drugs and Lactation Database (LactMed®)
Your browsing activity is empty.
Activity recording is turned off.
See more...