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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Butalbital

Last Revision: June 30, 2019.

Estimated reading time: 1 minute

CASRN: 77-26-9

Chemical structure

Drug Levels and Effects

Summary of Use during Lactation

Butalbital in breastmilk has caused poor feeding and vomiting in one infant. Other agents are preferred, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. A 7-day-old breastfed infant's urine was qualitatively positive for barbiturate after his mother took a combination of butalbital 50 mg with acetaminophen 325 mg and caffeine 50 mg every 6 hours for 24 hours.[1]

Effects in Breastfed Infants

The mother of a newborn took a product containing acetaminophen 325 mg, butalbital 50 mg, and caffeine 40 mg every 6 hours for 24 hours for a spinal headache, with the last dose a day prior to presentation at the emergency department. Her 7-day-old infant had a history of 1 to 2 days of poor feeding, lethargy and vomiting. The infant was somnolent, lethargic, and demonstrating diminished reflexes. The urine was qualitatively positive for barbiturate and had also had 1 mg/L of caffeine 15 hours after hospital admission. The infant's symptoms resolved within 24 hours. The symptoms were probably caused by butalbital.[1]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Vohra V, Marraffa JM. Maternal use of acetaminophen-butalbital-caffeine product resulting in neonate butalbital exposure through breast milk. Clin Toxicol. 2019;57:549. Abstract. DOI: 10.1080/15563650.2019.1598646. [CrossRef]

Substance Identification

Substance Name

Butalbital

CAS Registry Number

77-26-9

Drug Class

  • Breast Feeding
  • Barbiturates
  • GABA Modulators
  • Hypnotics and Sedatives

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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