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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.
CASRN: 139264-17-8
Drug Levels and Effects
Summary of Use during Lactation
Preliminary evidence indicates that zolmitriptan levels in breastmilk are low. Amounts ingested by the infant are small and unlikely to affect the nursing infant, especially if the infant is older than 2 months.
Drug Levels
Maternal Levels. Four women who were at least 1 month postpartum using zolmitriptan to treat migraine provided milk samples at intervals over a 24-hour period after a single dose. The authors estimated the weight-adjusted infant dosage to be 2.1% (range 0.7 to 5.3%).[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
References
- 1.
- Amundsen S, Nordeng H, Fuskevåg OM, et al. Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding. Reprod Toxicol. 2019;88:141. [CrossRef]
Substance Identification
Substance Name
Zolmitriptan
CAS Registry Number
139264-17-8
Drug Class
Breast Feeding
Serotonin Receptor Agonists
Serotonin 5-HT1 Receptor Agonists
Triptans
Vasoconstrictor Agents
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- Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan).[Br J Pharmacol. 1997]Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan).Martin GR, Robertson AD, MacLennan SJ, Prentice DJ, Barrett VJ, Buckingham J, Honey AC, Giles H, Moncada S. Br J Pharmacol. 1997 May; 121(2):157-64.
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