NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

Cover of Drugs and Lactation Database (LactMed)

Drugs and Lactation Database (LactMed) [Internet].

Show details

Azelaic Acid

Last Revision: October 31, 2018.

Estimated reading time: 1 minute

CASRN: 123-99-9

Chemical structure

Drug Levels and Effects

Summary of Use during Lactation

Topical azelaic acid has not been studied during breastfeeding. Because only 4% of a dose is absorbed after topical application and it is a chemical that appears in foods and the bloodstream normally, azelaic acid is considered a low risk to the nursing infant.[1][2] Ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[3]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

(Acne) Benzoyl Peroxide, Clindamycin, Erythromycin, Tretinoin; (Rosacea) Metronidazole

References

1.
Akhavan A, Bershad S. Topical acne drugs: review of clinical properties, systemic exposure, and safety. Am J Clin Dermatol. 2003;4:473-92. [PubMed: 12814337]
2.
Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006;24:167-97. [PubMed: 16677965]
3.
Noti A, Grob K, Biedermann M et al. Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38:317-25. [PubMed: 14623482]

Substance Identification

Substance Name

Azelaic Acid

CAS Registry Number

123-99-9

Drug Class

  • Breast Feeding
  • Antineoplastic Agents
  • Dermatologic Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site .

Views

Related information

Similar articles in PubMed

  • Review Econazole[Drugs and Lactation Database (...]
    Review Econazole
    . Drugs and Lactation Database (LactMed). 2006
  • Review Tretinoin[Drugs and Lactation Database (...]
    Review Tretinoin
    . Drugs and Lactation Database (LactMed). 2006
  • Review Fusidic Acid[Drugs and Lactation Database (...]
    Review Fusidic Acid
    . Drugs and Lactation Database (LactMed). 2006
  • Review Ciclopirox[Drugs and Lactation Database (...]
    Review Ciclopirox
    . Drugs and Lactation Database (LactMed). 2006
  • Review Adapalene[Drugs and Lactation Database (...]
    Review Adapalene
    . Drugs and Lactation Database (LactMed). 2006
See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...