Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 137071-32-0
Drug Levels and Effects
Summary of Use during Lactation
Topical pimecrolimus has not been studied during breastfeeding; however, it is used topically in children as young as 3 months of age. Because it is poorly absorbed after topical application and plasma concentrations after topical use in adults are less than 2 mcg/L, it is a low risk to the nursing infant. Ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Current guidelines allow topical pimecrolimus to be applied to the nipples just after nursing for eczema, with the nipples cleaned gently before nursing.[1,2]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
References
- 1.
- Vestergaard C, Wollenberg A, Barbarot S, et al. European task force on atopic dermatitis position paper: treatment of parental atopic dermatitis during preconception, pregnancy and lactation period. J Eur Acad Dermatol Venereol 2019;33:1644-59. [PubMed: 31231864]
- 2.
- Deleuran M, Dézfoulian B, Elberling J, et al. Systemic anti-inflammatory treatment of atopic dermatitis during conception, pregnancy and breastfeeding: Interdisciplinary expert consensus in Northern Europe. J Eur Acad Dermatol Venereol 2024;38:31-41. [PubMed: 37818828]
Substance Identification
Substance Name
Pimecrolimus
CAS Registry Number
137071-32-0
Drug Class
Breast Feeding
Milk, Human
Anti-Inflammatory Agents, Non-Steroidal
Dermatologic Agents
Immunosuppressive Agents
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- User and Medical Advice Disclaimer
- Drugs and Lactation Database (LactMed) - Record Format
- LactMed - Database Creation and Peer Review Process
- Fact Sheet. Drugs and Lactation Database (LactMed)
- Drugs and Lactation Database (LactMed) - Glossary
- LactMed Selected References
- Drugs and Lactation Database (LactMed) - About Dietary Supplements
- Breastfeeding Links
- PubChem SubstanceRelated PubChem Substances
- PubMedLinks to PubMed
- Review Tacrolimus.[Drugs and Lactation Database (...]Review Tacrolimus.. Drugs and Lactation Database (LactMed®). 2006
- Review Everolimus.[Drugs and Lactation Database (...]Review Everolimus.. Drugs and Lactation Database (LactMed®). 2006
- Possible antioxidant and neuroprotective mechanisms of FK506 in attenuating haloperidol-induced orofacial dyskinesia.[Eur J Pharmacol. 2003]Possible antioxidant and neuroprotective mechanisms of FK506 in attenuating haloperidol-induced orofacial dyskinesia.Singh A, Naidu PS, Kulkarni SK. Eur J Pharmacol. 2003 Sep 12; 477(2):87-94.
- Review Sirolimus.[Drugs and Lactation Database (...]Review Sirolimus.. Drugs and Lactation Database (LactMed®). 2006
- FK506-binding proteins regulate smooth muscle contractility by altering neurotransmitter release.[Eur J Pharmacol. 1997]FK506-binding proteins regulate smooth muscle contractility by altering neurotransmitter release.Kageyama M, Fujita H, Goto W, Nakata K, Shirasawa E, Kanai A. Eur J Pharmacol. 1997 Aug 27; 333(2-3):223-9.
- Pimecrolimus - Drugs and Lactation Database (LactMed®)Pimecrolimus - Drugs and Lactation Database (LactMed®)
Your browsing activity is empty.
Activity recording is turned off.
See more...