CASRN: 8050-81-5
Drug Levels and Effects
Summary of Use during Lactation
Although no data are available on the use of simethicone during breastfeeding, it is not absorbed orally. Therefore, it cannot be transferred to breastmilk.[1] It is also used safely given directly to infants.[2,3] No special precautions are required.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Mahadevan U, Kane S. American Gastroenterological Association Institute Technical Review on the Use of Gastrointestinal Medications in Pregnancy. Gastroenterology 2006;131:283-311 [PubMed: 16831611]
- 2.
- Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact 1998;14:259-62 [PubMed: 10205441]
- 3.
- Savino F, Pelle E, Palumeri E, et al. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: A prospective randomized study. Pediatrics 2007;119:e124-30 [PubMed: 17200238]
Substance Identification
Substance Name
Simethicone
CAS Registry Number
8050-81-5
Drug Class
Breast Feeding
Lactation
Milk, Human
Gastrointestinal Drugs
Antifoaming Agents
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Publication Details
Publication History
Last Revision: February 15, 2026.
Copyright
Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
Publisher
National Institute of Child Health and Human Development, Bethesda (MD)
NLM Citation
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Simethicone. [Updated 2026 Feb 15].