NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

Cover of Drugs and Lactation Database (LactMed)

Drugs and Lactation Database (LactMed) [Internet].

Show details

Pentobarbital

Last Revision: October 31, 2018.

Estimated reading time: 1 minute

CASRN: 76-74-4

Chemical structure

Drug Levels and Effects

Summary of Use during Lactation

Because there is little published experience with pentobarbital during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. A mother who was 4 days postpartum had taken pentobarbital 100 mg daily for 3 days. A milk level of 170 mcg/L was measured 19 hours after the previous dose.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Zaleplon, Zolpidem

References

1.
Horning MG, Stillwell WG, Nowlin J et al. Identification and quantification of drugs and drug metabolites in human breast milk using GC-MS-COM methods. Mod Probl Paediatr. 1975;15:73-9.

Substance Identification

Substance Name

Pentobarbital

CAS Registry Number

76-74-4

Drug Class

  • Breast Feeding
  • Barbiturates
  • Hypnotics and Sedatives
  • GABA Modulators

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Views

Related information

Similar articles in PubMed

  • Review Secobarbital[Drugs and Lactation Database (...]
    Review Secobarbital
    . Drugs and Lactation Database (LactMed). 2006
  • Review Butabarbital[Drugs and Lactation Database (...]
    Review Butabarbital
    . Drugs and Lactation Database (LactMed). 2006
  • Review Thiopental[Drugs and Lactation Database (...]
    Review Thiopental
    . Drugs and Lactation Database (LactMed). 2006
  • Review Phenobarbital[Drugs and Lactation Database (...]
    Review Phenobarbital
    . Drugs and Lactation Database (LactMed). 2006
  • Review Butalbital[Drugs and Lactation Database (...]
    Review Butalbital
    . Drugs and Lactation Database (LactMed). 2006
See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...