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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Last Revision: October 31, 2018.

Estimated reading time: 1 minute

CASRN: 62893-19-0

Chemical structure

Drug Levels and Effects

Summary of Use during Lactation

Limited information indicates cefoperazone produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. Cefoperazone is acceptable in nursing mothers.

Drug Levels

Maternal Levels. After 1 gram of cefoperazone intravenously in 5 women, it was undetectable in milk in 2 women at any time up to 6 hours after the dose. The average peak milk levels of 0.33 mg/L occurred 2 hours after the dose, but in individuals, peak levels occurred 2, 3 or 4 hours after the dose.[1]

After 1 gram of cefoperazone given intravenously in 2 women, milk cefoperazone was 0.1 mg/L at 2 hours and 0.3 mg/L 3 hours after the dose. It was undetectable in milk 1 and 6 hours after the dose.[2][3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.


Takase Z, Shirafuji H, Uchida M. Fundamental and clinical studies of cefoperazone (T-1551) in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1980;28 (Suppl 6):825-36.
Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. [PubMed: 6743732]
Matsuda S, Kashiwagura T, Hirayama H. Passage into the human milk and clinical evaluation of sulbactam/cefoperazone. Jpn J Antibiot. 1985;38:223-9. [PubMed: 2989572]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

  • Breast Feeding
  • Anti-Infective Agents
  • Antibacterial Agents
  • Cephalosporins

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.


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