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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Fosfomycin

Last Revision: September 21, 2020.

Estimated reading time: 1 minute

CASRN: 23155-02-4

image 134994616 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Limited information indicates that fosfomycin produces low levels in milk and is unlikely to be absorbed well by the infant because of the binding to calcium in the milk.[1] It is unlikely to cause any adverse effects in breastfed infants.

Drug Levels

Maternal Levels. After 1 to 2 grams of fosfomycin given by injection, colostrum levels in 2 women were 4.8 mg/L and milk levels were 3.6 mg/L.[2,3] Further details of the studies were not given.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Lebedevs T. Fosfomycin and breastfeeding. Aust Prescr 2020;43:113. Letter. doi:10.18773/austprescr.2020.042. [PMC free article: PMC7450774] [PubMed: 32921885] [CrossRef]
2.
Gallego A, Rodríguez A, Mata A. Fosfomycin: pharmacological studies. Drugs Today (Barc). 1974;10 Suppl 1:161–8.
3.
Kirby WM. Pharmacokinetics of fosfomycin. Chemotherapy. 1977;23 Suppl 1:141–51. [PubMed: 832510]

Substance Identification

Substance Name

Fosfomycin

CAS Registry Number

23155-02-4

Drug Class

Breast Feeding

Lactation

Antibacterial Agents

Anti-Infective Agents, Urinary

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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