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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 54182-58-0
Drug Levels and Effects
Summary of Use during Lactation
No data are available on sucralfate use during breastfeeding; however, it is virtually unabsorbed orally. Most authorities consider sucralfate acceptable to use during breastfeeding.[1-4] No special precautions are required, including following application to the nipples in a skin cream.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
A study of mother with cracked nipples compared the effects of soft paraffin (petrolatum) (n = 47) to a commercial cream containing sucralfate, zinc and copper (Cicalfate-Avene, France) (n = 68). Reduction of nipple cracking judged by a blinded dermatologist was 3.3 to 5.3 times greater in the sucralfate group compared to the petrolatum group.[5]
Alternate Drugs to Consider
References
- 1.
- Lewis JH, Weingold AB., Committee of FDA-Related Matters American College of Gastroenterology. The use of gastrointestinal drugs during pregnancy and lactation. Am J Gastroenterol. 1985;80:912–23. [PubMed: 2864852]
- 2.
- Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact. 1998;14:259–62. [PubMed: 10205441]
- 3.
- Broussard CN, Richter JE. Treating gastro-oesophageal reflux disease during pregnancy and lactation: What are the safest therapy options? Drug Saf. 1998;19:325–37. [PubMed: 9804446]
- 4.
- Richter JE. Review article: The management of heartburn in pregnancy. Aliment Pharmacol Ther. 2005;22:749–57. [PubMed: 16225482]
- 5.
- Talaee R, Mohammadzadeh M, Rahimi H. Comparing the combination of copper, zinc, and sucralfate (Cicalfate®) with white soft paraffin in the treatment of cracked nipples. Iran J Dermatol. 2021;24:18–23.
Substance Identification
Substance Name
Sucralfate
CAS Registry Number
54182-58-0
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Oligosaccharide polyesters from roots of Polygala glomerata.[Phytochemistry. 1998]Oligosaccharide polyesters from roots of Polygala glomerata.Zhang D, Miyase T, Kuroyanagi M, Umehara K, Noguchi H. Phytochemistry. 1998 Jan; 47(1):45-52.
- Sucralfate - Drugs and Lactation Database (LactMed®)Sucralfate - Drugs and Lactation Database (LactMed®)
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