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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Bismuth Subsalicylate

Last Revision: October 31, 2018.

Estimated reading time: 1 minute

CASRN: 14882-18-9

Chemical structure

Drug Levels and Effects

Summary of Use during Lactation

Because of the possibility of absorption of salicylate from the breastmilk by the infant, alternatives are preferred.[1]

Drug Levels

Maternal Levels. No published information was found on the use of bismuth subsalicylate during breastfeeding. Infant salicylate intake is estimated to be less than 1% of the maternal dose when both drug and metabolite are considered.[2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

One case report of metabolic acidosis was caused by salicylate in a 16-day old breastfed infant whose mother was taking aspirin 650 mg every 4 hours for arthritis.[3] However, there was no measurement of salicylate in maternal serum or milk and it is unclear whether the infant had received any salicylate directly.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

(Diarrhea) Loperamide; (Heartburn) Antacids, Cimetidine, Famotidine, Nizatidine, Omeprazole, Pantoprazole, Ranitidine

References

1.
Lewis JH, Weingold AB and the Committee of FDA-Related Matters, American College of Gastroenterology. The use of gastrointestinal drugs during pregnancy and lactation. Am J Gastroenterol. 1985;80:912-23. [PubMed: 2864852]
2.
Levy G. Salicylate pharmacokinetics in the human neonate. In, Morselli PL, Garattini S, Sereni F, eds. Basic and therapeutic aspects of perinatal pharmacology. 1975; Raven Press: New York:319-30.
3.
Clark JH, Wilson WG. A 16-day-old breast-fed infant with metabolic acidosis caused by salicylate. Clin Pediatr (Phila). 1981;20:53-4. [PubMed: 7449246]

Substance Identification

Substance Name

Bismuth Subsalicylate

CAS Registry Number

14882-18-9

Drug Class

  • Breast Feeding
  • Bismuth
  • Salicylates
  • Gastrointestinal Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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